CSPG5

CSPG5
Identifiers
Aliases	CSPG5 , NGC, chondroitin sulfate proteoglycan 5
External IDs	OMIM: 606775 MGI: 1352747 HomoloGene: 4795 GeneCards: CSPG5
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3p21.31 Start 47,562,238 bp [1] End 47,580,792 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 F2 Start 110,072,851 bp [2] End 110,091,644 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell retinal pigment epithelium frontal pole Brodmann area 23 Brodmann area 10 Region I of hippocampus proper orbitofrontal cortex entorhinal cortex Brodmann area 46 superior frontal gyrus Top expressed in visual cortex superior frontal gyrus cingulate gyrus prefrontal cortex primary motor cortex piriform cortex olfactory tubercle dorsomedial hypothalamic nucleus globus pallidus subiculum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding growth factor activity Cellular component integral component of membrane Golgi apparatus endoplasmic reticulum membrane membrane Golgi membrane plasma membrane integral component of plasma membrane extracellular region cell surface lysosomal lumen endoplasmic reticulum Golgi lumen Golgi-associated vesicle membrane glutamatergic synapse GABA-ergic synapse integral component of postsynaptic membrane Biological process cell differentiation chondroitin sulfate biosynthetic process modulation of chemical synaptic transmission intracellular transport nervous system development multicellular organism development chondroitin sulfate catabolic process regulation of growth dermatan sulfate biosynthetic process regulation of signaling receptor activity trans-synaptic signaling, modulating synaptic transmission regulation of synaptic vesicle exocytosis cytoskeleton organization glial cell projection elongation positive regulation of substrate adhesion-dependent cell spreading signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10675 29873 Ensembl ENSG00000114646 ENSMUSG00000032482 UniProt O95196 Q71M36 RefSeq (mRNA) NM_006574 NM_001206942 NM_001206943 NM_001206944 NM_001206945 NM_001166273 NM_013884 RefSeq (protein) NP_001193871 NP_001193872 NP_001193873 NP_001193874 NP_006565 NP_001159745 NP_038912 Location (UCSC) Chr 3: 47.56 – 47.58 Mb Chr 9: 110.07 – 110.09 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Chondroitin sulfate proteoglycan 5 is a protein that in humans is encoded by the CSPG5 gene. ^{[5] [6]}

Interactions

CSPG5 has been shown to interact with GOPC. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000114646 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032482 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yasuda Y, Tokita Y, Aono S, Matsui F, Ono T, Sonta S, Watanabe E, Nakanishi Y, Oohira A (May 1999). "Cloning and chromosomal mapping of the human gene of neuroglycan C (NGC), a neural transmembrane chondroitin sulfate proteoglycan with an EGF module". Neurosci Res. 32 (4): 313–22. doi:10.1016/S0168-0102(98)00098-4. PMID   9950058. S2CID   39609929.
6. "Entrez Gene: CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C)".
7. Hassel, Burkhard; Schreff Matthias; Stube Eva-Maria; Blaich Uta; Schumacher Stefan (Oct 2003). "CALEB/NGC interacts with the Golgi-associated protein PIST". J. Biol. Chem. United States. 278 (41): 40136–43. doi: 10.1074/jbc.M305577200 . ISSN   0021-9258. PMID   12885772.

Further reading

• Ichihara-Tanaka K, Oohira A, Rumsby M, Muramatsu T (2006). "Neuroglycan C is a novel midkine receptor involved in process elongation of oligodendroglial precursor-like cells". J. Biol. Chem. 281 (41): 30857–64. doi: 10.1074/jbc.M602228200 . PMID   16901907.
• Aono S, Tokita Y, Yasuda Y, et al. (2006). "Expression and identification of a new splice variant of neuroglycan C, a transmembrane chondroitin sulfate proteoglycan, in the human brain". J. Neurosci. Res. 83 (1): 110–8. doi:10.1002/jnr.20698. PMID   16299773. S2CID   45306074.
• Kinugasa Y, Ishiguro H, Tokita Y, et al. (2004). "Neuroglycan C, a novel member of the neuregulin family". Biochem. Biophys. Res. Commun. 321 (4): 1045–9. doi:10.1016/j.bbrc.2004.07.066. PMID   15358134.
• Hassel B, Schreff M, Stube EM, et al. (2003). "CALEB/NGC interacts with the Golgi-associated protein PIST". J. Biol. Chem. 278 (41): 40136–43. doi: 10.1074/jbc.M305577200 . PMID   12885772.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.

External links

• Human CSPG5 genome location and CSPG5 gene details page in the UCSC Genome Browser .