Uteroglobin

Last updated
SCGB1A1
Identifiers
Aliases SCGB1A1 , CC10, CC16, CCPBP, CCSP, UGB, UP-1, UP1, secretoglobin family 1A member 1
External IDs OMIM: 192020 MGI: 98919 HomoloGene: 2518 GeneCards: SCGB1A1
Gene location (Human)
Ideogram human chromosome 11.svg
Chr. Chromosome 11 (human) [1]
Human chromosome 11 ideogram.svg
HSR 1996 II 3.5e.svg
Red rectangle 2x18.png
Band 11q12.3Start62,405,103 bp [1]
End62,423,195 bp [1]
RNA expression pattern
PBB GE SCGB1A1 205725 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003357

NM_011681

RefSeq (protein)

NP_003348

NP_035811

Location (UCSC) Chr 11: 62.41 – 62.42 Mb Chr 19: 9.08 – 9.09 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Uteroglobin, also known as secretoglobin family 1A member 1 (SCGB1A1), is a protein that in humans is encoded by the SCGB1A1 gene. [5]

Protein biological molecule consisting of chains of amino acid residues

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific three-dimensional structure that determines its activity.

Gene basic physical and functional unit of heredity

In biology, a gene is a sequence of nucleotides in DNA or RNA that codes for a molecule that has a function. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic trait. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes as well as gene–environment interactions. Some genetic traits are instantly visible, such as eye color or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that constitute life.

Contents

SCGB1A1 is the founding member of the secretoglobin family of small, secreted, disulfide-bridged dimeric proteins found only in mammals. [6] This antiparallel disulfide linked homodimeric protein is multifunctional and found in various tissues in various names such as: uteroglobin (UG, UGB), uteroglobin-like antigen (UGL), blastokinin, club-cell secretory protein (CCSP), Clara-cell 16 kD protein (17 in rat/mice), club-cell-specific 10 kD protein (CC10), human protein 1, urine protein 1 (UP-1), polychlorinated biphenyl-binding protein (PCB-BP), human club cell phospholipid-binding protein (hCCPBP), secretoglobin 1A member 1 (SCGB1A1). [7]

A family of small disulfide linked dimeric proteins found only in mammals.

This protein is specifically expressed in club cells in the lungs. [8]

Club cells, also known as bronchiolar exocrine cells, and originally known as Clara cells, are dome-shaped cells with short microvilli, found in the small airways (bronchioles) of the lungs.

Function

The precise physiological role of uteroglobin is not yet known. Putative functions are:

  1. Immunomodulation
  2. Progesterone binding: weak in some animals, especially weak in humans. (Note: UGB is itself progesterone induced gene in the endometrium in Lagomorphs)
  3. Inhibits phospholipase A2 in vitro
  4. Binds phosphatidylcholine, phosphatidylinositol
  5. Binds to fibronectin: The uteroglobulin knockout mice on the inbred C57Bl6 strain develop Goodpasture's syndrome like glomerulopathy due to fibronectin binding of IgA which might potentially be prevented by uteroglobin replacement. However contrary to the animal model claims, human genetic data might suggest that the effect may be indirect [9]
  6. Uteroglobin knockout mice on the inbred 129 strain appear to have healthy phenotype (no glomerulopathy development), but show physiological differences in their responses to respiratory challenges. The phenotype exhibited by these mice are; decreased bioaccumulation of biphenyls, susceptibility and increased IL-13, and IL-6 following hyperoxic challenge, and changes in the club cell morphology. [10]
  7. Target of polychlorinated biphenyl (pcb) binding

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000149021 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024653 - Ensembl, May 2017
  3. "Human PubMed Reference:".
  4. "Mouse PubMed Reference:".
  5. Wolf M, Klug J, Hackenberg R, Gessler M, Grzeschik KH, Beato M, Suske G (September 1992). "Human CC10, the homologue of rabbit uteroglobin: genomic cloning, chromosomal localization and expression in endometrial cell lines". Hum. Mol. Genet. 1 (6): 371–8. doi:10.1093/hmg/1.6.371. PMID   1284526.
  6. Laukaitis CM, Karn RC (2005). "Evolution of the secretoglobins: a genomic and proteomic view". Biological Journal of the Linnean Society. 84 (3): 493–501. doi:10.1111/j.1095-8312.2005.00450.x.
  7. Klug J, Beier HM, Bernard A, Chilton BS, Fleming TP, Lehrer RI, Miele L, Pattabiraman N, Singh G (2000). "Uteroglobin/Clara cell 10-kDa family of proteins: nomenclature committee report". Ann. N. Y. Acad. Sci. 923: 348–54. doi:10.1111/j.1749-6632.2000.tb05549.x. PMID   11193777.
  8. Zhang, Liqian; Whitsett, Jeffrey A.; Stripp, Barry R. (1997). "Regulation of Clara cell secretory protein gene transcription by thyroid transcription factor-1". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1350 (3): 359–367. doi:10.1016/S0167-4781(96)00180-7.
  9. Vollmer M, Krapf R, Hildebrandt F (1998). "Exclusion of the uteroglobin gene as a candidate for fibronectin glomerulopathy (GFND)". Nephrol. Dial. Transplant. 13 (9): 2417–8. doi:10.1093/ndt/13.9.2417. PMID   9761542.
  10. Stripp BR, Reynolds SD, Boe IM, Lund J, Power JH, Coppens JT, Wong V, Reynolds PR, Plopper CG (August 2002). "Clara cell secretory protein deficiency alters clara cell secretory apparatus and the protein composition of airway lining fluid". Am. J. Respir. Cell Mol. Biol. 27 (2): 170–8. doi:10.1165/ajrcmb.27.2.200200270c. PMID   12151308.

Further reading

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