Brevican

BCAN
Identifiers
Aliases	BCAN , BEHAB, CSPG7, Brevican
External IDs	OMIM: 600347; MGI: 1096385; HomoloGene: 7244; GeneCards: BCAN; OMA:BCAN - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q23.1 Start 156,641,390 bp [1] End 156,659,532 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3 F1|3 38.78 cM Start 87,987,531 bp [2] End 88,000,230 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone amygdala anterior cingulate cortex right frontal lobe nucleus accumbens caudate nucleus putamen ganglionic eminence prefrontal cortex Brodmann area 9 Top expressed in superior frontal gyrus entorhinal cortex primary visual cortex perirhinal cortex CA3 field dentate gyrus of hippocampal formation granule cell cerebellar cortex central gray substance of midbrain nucleus of stria terminalis superior colliculus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function hyaluronic acid binding carbohydrate binding extracellular matrix structural constituent Cellular component membrane extracellular region lysosomal lumen Golgi lumen anchored component of membrane extracellular matrix glutamatergic synapse Biological process skeletal system development chondroitin sulfate biosynthetic process extracellular matrix organization central nervous system development chondroitin sulfate catabolic process dermatan sulfate biosynthetic process hippocampus development cell adhesion synapse maturation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 63827 12032 Ensembl ENSG00000132692 ENSMUSG00000004892 UniProt Q96GW7 Q61361 RefSeq (mRNA) NM_021948 NM_198427 NM_001109758 NM_007529 RefSeq (protein) NP_068767 NP_940819 NP_001103228 NP_031555 Location (UCSC) Chr 1: 156.64 – 156.66 Mb Chr 3: 87.99 – 88 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Brevican core protein is a protein that in humans is encoded by the BCAN gene. ^{[5] [6] [7]} Brevican is a member of the lectican protein family.

Brevican is localised to the surface of neurons in the brain. ^[8] In melanocytic cells, BCAN gene expression may be regulated by MITF. ^[9]

Brevican is involved in maintaining molecule networks around neurons and may possibly be associated with slower brain ageing and Alzheimer's prevention. ^[10]

References

1. GRCh38: Ensembl release 89: ENSG00000132692 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000004892 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gary SC, Zerillo CA, Chiang VL, Gaw JU, Gray G, Hockfield S (Oct 2000). "cDNA cloning, chromosomal localization, and expression analysis of human BEHAB/brevican, a brain specific proteoglycan regulated during cortical development and in glioma". Gene. 256 (1–2): 139–47. doi: 10.1016/S0378-1119(00)00362-0 . PMID   11054543.
6. Nomoto H, Oohashi T, Hirakawa S, Ueki Y, Ohtsuki H, Ninomiya Y (Feb 2002). "Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23". Acta Medica Okayama. 56 (1): 25–9. PMID   11873941.
7. "Entrez Gene: BCAN brevican".
8. Frischknecht R, Seidenbecher CI (Jul 2012). "Brevican: a key proteoglycan in the perisynaptic extracellular matrix of the brain". The International Journal of Biochemistry & Cell Biology. 44 (7): 1051–4. doi:10.1016/j.biocel.2012.03.022. PMID   22537913.
9. Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (Dec 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi: 10.1111/j.1755-148X.2008.00505.x . PMID   19067971.
10. Naddaf, Miryam (2024-12-09). "How fast is your brain ageing? Proteins in blood offer clues" . Nature. doi:10.1038/d41586-024-04055-0. ISSN   1476-4687.

Further reading

• Hu B, Kong LL, Matthews RT, Viapiano MS (Sep 2008). "The proteoglycan brevican binds to fibronectin after proteolytic cleavage and promotes glioma cell motility". The Journal of Biological Chemistry. 283 (36): 24848–59. doi: 10.1074/jbc.M801433200 . PMC   3259830 . PMID   18611854.
• Seidenbecher CI, Richter K, Rauch U, Fässler R, Garner CC, Gundelfinger ED (Nov 1995). "Brevican, a chondroitin sulfate proteoglycan of rat brain, occurs as secreted and cell surface glycosylphosphatidylinositol-anchored isoforms". The Journal of Biological Chemistry. 270 (45): 27206–12. doi: 10.1074/jbc.270.45.27206 . PMID   7592978.
• Aspberg A, Miura R, Bourdoulous S, Shimonaka M, Heinegârd D, Schachner M, Ruoslahti E, Yamaguchi Y (Sep 1997). "The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety". Proceedings of the National Academy of Sciences of the United States of America. 94 (19): 10116–21. Bibcode:1997PNAS...9410116A. doi: 10.1073/pnas.94.19.10116 . PMC   23322 . PMID   9294172.
• Nakamura H, Fujii Y, Inoki I, Sugimoto K, Tanzawa K, Matsuki H, Miura R, Yamaguchi Y, Okada Y (Dec 2000). "Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites". The Journal of Biological Chemistry. 275 (49): 38885–90. doi: 10.1074/jbc.M003875200 . PMID   10986281.
• Olin AI, Mörgelin M, Sasaki T, Timpl R, Heinegård D, Aspberg A (Jan 2001). "The proteoglycans aggrecan and Versican form networks with fibulin-2 through their lectin domain binding". The Journal of Biological Chemistry. 276 (2): 1253–61. doi: 10.1074/jbc.M006783200 . PMID   11038354.
• Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Xu XM, Chen Y, Chen J, Yang S, Gao F, Underhill CB, Creswell K, Zhang L (Sep 2003). "A peptide with three hyaluronan binding motifs inhibits tumor growth and induces apoptosis". Cancer Research. 63 (18): 5685–90. PMID   14522884.
• Bekku Y, Su WD, Hirakawa S, Fässler R, Ohtsuka A, Kang JS, Sanders J, Murakami T, Ninomiya Y, Oohashi T (Sep 2003). "Molecular cloning of Bral2, a novel brain-specific link protein, and immunohistochemical colocalization with brevican in perineuronal nets". Molecular and Cellular Neurosciences. 24 (1): 148–59. doi:10.1016/S1044-7431(03)00133-7. PMID   14550776. S2CID   25762224.
• Dong Y, Han X, Xue Y, Dong B, Guo X, Hu G, Zhu C, Lu Y (Feb 2004). "Secreted brevican mRNA is expressed in the adult rat pituitary". Biochemical and Biophysical Research Communications. 314 (3): 745–8. doi:10.1016/j.bbrc.2003.12.151. PMID   14741698.
• Viapiano MS, Bi WL, Piepmeier J, Hockfield S, Matthews RT (Aug 2005). "Novel tumor-specific isoforms of BEHAB/brevican identified in human malignant gliomas". Cancer Research. 65 (15): 6726–33. doi: 10.1158/0008-5472.CAN-05-0585 . PMID   16061654.
• Nakada M, Miyamori H, Kita D, Takahashi T, Yamashita J, Sato H, Miura R, Yamaguchi Y, Okada Y (Sep 2005). "Human glioblastomas overexpress ADAMTS-5 that degrades brevican". Acta Neuropathologica. 110 (3): 239–46. doi:10.1007/s00401-005-1032-6. PMID   16133547. S2CID   25744956.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.

External links

• Human BCAN genome location and BCAN gene details page in the UCSC Genome Browser .