Neurocan

Last updated
NCAN
Identifiers
Aliases NCAN , CSPG3, neurocan
External IDs OMIM: 600826 MGI: 104694 HomoloGene: 3229 GeneCards: NCAN
Orthologs
SpeciesHumanMouse
Entrez

1463

13004

Ensembl

ENSG00000130287

ENSMUSG00000002341

UniProt

O14594

P55066

RefSeq (mRNA)

NM_004386

NM_007789

RefSeq (protein)

NP_004377

NP_031815

Location (UCSC) Chr 19: 19.21 – 19.25 Mb Chr 8: 70.55 – 70.57 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Neurocan core protein is a protein that in humans is encoded by the NCAN gene. [5] [6]

Contents

Neurocan is a member of the lectican / chondroitin sulfate proteoglycan protein families and consists of neurocan core protein and chondroitin sulfate. It is thought to be involved in the modulation of cell adhesion and migration. [6]

Role in bipolar disorder

Neurocan is a significant component of the extracellular matrix, and its levels are modulated by a variety of factors, but mice in which the NCAN gene has been knocked out show no easily observable defects in brain development or behavior. [7] However, a genome-wide association study published in 2011 identified Neurocan as a susceptibility factor for bipolar disorder. [8] A more comprehensive study published in 2012 confirmed that association. [9] The 2012 study examined correlations between NCAN alleles and various symptoms of bipolar disorder, and also examined the behavior of NCAN knockout mice. In the human subjects, it was found that NCAN genotype was strongly associated with manic symptoms but not with depressive symptoms. In the mice, the absence of functional Neurocan resulted in a variety of manic-like behaviors, which could be normalized by administering lithium.

Related Research Articles

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<span class="mw-page-title-main">Aggrecan</span>

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<span class="mw-page-title-main">CSPG4</span>

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<span class="mw-page-title-main">Glypican 1</span>

Glypican-1 (GPC1) is a protein that in humans is encoded by the GPC1 gene. GPC1 is encoded by human GPC1 gene located at 2q37.3. GPC1 contains 558 amino acids with three predicted heparan sulfate chains.

<span class="mw-page-title-main">MMP16</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">Collagen, type XIV, alpha 1</span> Mammalian protein found in Homo sapiens

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<span class="mw-page-title-main">Brevican</span> Protein-coding gene in the species Homo sapiens

Brevican core protein is a protein that in humans is encoded by the BCAN gene. Brevican is a member of the lectican protein family.

<span class="mw-page-title-main">XYLT1</span>

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<span class="mw-page-title-main">B3GAT3</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">CSPG5</span>

Chondroitin sulfate proteoglycan 5 is a protein that in humans is encoded by the CSPG5 gene.

<span class="mw-page-title-main">Carbohydrate sulfotransferase</span>

Carbohydrate sulfotransferases are sulfotransferase enzymes that transfer sulfate to carbohydrate groups in glycoproteins and glycolipids. Carbohydrates are used by cells for a wide range of functions from structural purposes to extracellular communication. Carbohydrates are suitable for such a wide variety of functions due to the diversity in structure generated from monosaccharide composition, glycosidic linkage positions, chain branching, and covalent modification. Possible covalent modifications include acetylation, methylation, phosphorylation, and sulfation. Sulfation, performed by carbohydrate sulfotransferases, generates carbohydrate sulfate esters. These sulfate esters are only located extracellularly, whether through excretion into the extracellular matrix (ECM) or by presentation on the cell surface. As extracellular compounds, sulfated carbohydrates are mediators of intercellular communication, cellular adhesion, and ECM maintenance.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000130287 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000002341 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Rauch U, Karthikeyan L, Maurel P, Margolis RU, Margolis RK (Oct 1992). "Cloning and primary structure of neurocan, a developmentally regulated, aggregating chondroitin sulfate proteoglycan of brain". J Biol Chem. 267 (27): 19536–47. doi: 10.1016/S0021-9258(18)41808-X . PMID   1326557.
  6. 1 2 "Entrez Gene: NCAN neurocan".
  7. ↑ Zhou XH, Brakebusch C, Matthies H, Oohashi T, Hirsch E, Moser M, Krug M, Seidenbecher CI, Boeckers TM, Rauch U, Buettner R, Gundelfinger ED, Fässler R (September 2001). "Neurocan is dispensable for brain development". Mol. Cell. Biol. 21 (17): 5970–8. doi:10.1128/MCB.21.17.5970-5978.2001. PMC   87315 . PMID   11486035.
  8. ↑ Cichon S, Mühleisen TW, Degenhardt FA, Mattheisen M, Miró X, Strohmaier J, Steffens M, Meesters C, Herms S, Weingarten M, Priebe L, Haenisch B, Alexander M, Vollmer J, Breuer R, Schmäl C, Tessmann P, Moebus S, Wichmann HE, Schreiber S, Müller-Myhsok B, Lucae S, Jamain S, Leboyer M, Bellivier F, Etain B, Henry C, Kahn JP, Heath S, Hamshere M, O'Donovan MC, Owen MJ, Craddock N, Schwarz M, Vedder H, Kammerer-Ciernioch J, Reif A, Sasse J, Bauer M, Hautzinger M, Wright A, Mitchell PB, Schofield PR, Montgomery GW, Medland SE, Gordon SD, Martin NG, Gustafsson O, Andreassen O, Djurovic S, Sigurdsson E, Steinberg S, Stefansson H, Stefansson K, Kapur-Pojskic L, Oruc L, Rivas F, Mayoral F, Chuchalin A, Babadjanova G, Tiganov AS, Pantelejeva G, Abramova LI, Grigoroiu-Serbanescu M, Diaconu CC, Czerski PM, Hauser J, Zimmer A, Lathrop M, Schulze TG, Wienker TF, Schumacher J, Maier W, Propping P, Rietschel M, Nöthen MM (March 2011). "Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder". Am. J. Hum. Genet. 88 (3): 372–81. doi:10.1016/j.ajhg.2011.01.017. PMC   3059436 . PMID   21353194.
  9. ↑ Miró X, Meier S, Dreisow ML, Frank J, Strohmaier J, Breuer R, Schmäl C, Albayram Ö, Pardo-Olmedilla MT, Mühleisen TW, Degenhardt FA, Mattheisen M, Reinhard I, Bilkei-Gorzo A, Cichon S, Seidenbecher C, Rietschel M, Nöthen MM, Zimmer A (September 2012). "Studies in humans and mice implicate neurocan in the etiology of mania". Am J Psychiatry. 169 (9): 982–90. doi:10.1176/appi.ajp.2012.11101585. PMID   22952076. S2CID   13621844.

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