SIGLEC5

Last updated
SIGLEC5
Protein SIGLEC5 PDB 2ZG1.png
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases SIGLEC5 , CD170, CD33L2, OB-BP2, OBBP2, SIGLEC-5, sialic acid binding Ig like lectin 5
External IDs OMIM: 604200 HomoloGene: 55783 GeneCards: SIGLEC5
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003830
NM_001384708
NM_001384709

n/a

RefSeq (protein)

NP_003821

n/a

Location (UCSC) Chr 19: 51.61 – 51.63 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

Sialic acid-binding Ig-like lectin 5 is a protein that in humans is encoded by the SIGLEC5 gene. [3] [4] SIGLEC5 has also been designated CD170 (cluster of differentiation 170).

Contents


Related Research Articles

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<span class="mw-page-title-main">Sialoadhesin</span>

Sialoadhesin is a cell adhesion molecule found on the surface of macrophages. It is found in especially high amounts on macrophages of the spleen, liver, lymph node, bone marrow, colon, and lungs. Also, in patients with rheumatoid arthritis, the protein has been found in great amounts on macrophages of the affected tissues. It is defined as an I-type lectin, since it contains 17 immunoglobulin (Ig) domains, and thus also belongs to the immunoglobulin superfamily (IgSF). Sialoadhesin binds to certain molecules called sialic acids. During this binding process a salt bridge (protein) is formed between a highly conserved arginine residue and the carboxylate group of the sialic acid. Since sialoadhesin binds sialic acids with its N-terminal IgV-domain, it is also a member of the SIGLEC family. Alternate names for sialoadhesin include siglec-1 and CD169.

<span class="mw-page-title-main">CD33</span> Mammalian protein found in Homo sapiens

CD33 or Siglec-3 is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells.

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<span class="mw-page-title-main">SIGLEC7</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">Sialic acid-binding Ig-like lectin 12</span> Protein-coding gene in the species Homo sapiens

Sialic acid-binding Ig-like lectin 12, or Siglec-XII, is a protein that in humans, is encoded by the SIGLEC12 gene.

<span class="mw-page-title-main">FOLR2</span>

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<span class="mw-page-title-main">SIGLEC9</span> Protein-coding gene in the species Homo sapiens

Sialic acid-binding Ig-like lectin 9 is a protein that in humans is encoded by the SIGLEC9 gene.

<span class="mw-page-title-main">SIGLEC10</span> Protein-coding gene in the species Homo sapiens

Sialic acid-binding Ig-like lectin 10 is a protein that in humans is encoded by the SIGLEC10 gene. Siglec-G is often referred to as the murine paralog of human Siglec-10

<span class="mw-page-title-main">CD79B</span> Mammalian protein found in Homo sapiens

CD79b molecule, immunoglobulin-associated beta, also known as CD79B, is a human gene.

<span class="mw-page-title-main">SIGLEC6</span> Protein-coding gene in the species Homo sapiens

Sialic acid-binding Ig-like lectin 6 is a protein that in humans is encoded by the SIGLEC6 gene. The gene was originally named CD33L (CD33-like) due to similarities between these genes but later became known as OB-BP1 due to its ability to bind to this factor and, finally, SIGLEC6 as the sixth member of the SIGLEC family of receptors to be identified. The protein has also been given the CD designation CD327.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000268500 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Kim HS (Jun 1999). "Assignment of the human OB binding protein-2 gene (CD33L2) to chromosome 19q13.3 by radiation hybrid mapping". Cytogenet Cell Genet. 84 (1–2): 96. doi:10.1159/000015227. PMID   10343116. S2CID   10581090.
  4. "Entrez Gene: SIGLEC5 sialic acid binding Ig-like lectin 5".

Further reading