LAIR2

LAIR2
Identifiers
Aliases	LAIR2 , CD306, leukocyte associated immunoglobulin like receptor 2
External IDs	OMIM: 602993 HomoloGene: 88663 GeneCards: LAIR2
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.42 Start 54,497,879 bp [1] End 54,510,687 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in placenta blood lymph node appendix monocyte bone marrow spleen right coronary artery right lung duodenum n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component extracellular region Biological process regulation of immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3904 n/a Ensembl ENSG00000167618 ENSG00000275819 ENSG00000277335 ENSG00000274084 n/a UniProt Q6ISS4 n/a RefSeq (mRNA) NM_002288 NM_021270 n/a RefSeq (protein) NP_002279 NP_067154 n/a Location (UCSC) Chr 19: 54.5 – 54.51 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Leukocyte-associated immunoglobulin-like receptor 2 is a protein that in humans is encoded by the LAIR2 gene. ^{[3] [4]}

The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity to LAIR1, an inhibitory receptor present on mononuclear leukocytes. This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily, including LAIR1. The function of this protein is unknown, although it is thought to be secreted and may help modulate mucosal tolerance. Two transcript variants encoding different isoforms have been found for this gene. ^[4]

References

1. ENSG00000275819, ENSG00000277335, ENSG00000274084 GRCh38: Ensembl release 89: ENSG00000167618, ENSG00000275819, ENSG00000277335, ENSG00000274084 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Meyaard L, Adema GJ, Chang C, Woollatt E, Sutherland GR, Lanier LL, Phillips JH (Sep 1997). "LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes". Immunity. 7 (2): 283–90. doi: 10.1016/S1074-7613(00)80530-0 . hdl: 2066/26173 . PMID   9285412.
4. "Entrez Gene: LAIR2 leukocyte-associated immunoglobulin-like receptor 2".

Further reading

• Lebbink RJ, van den Berg MC, de Ruiter T, et al. (2008). "The soluble leukocyte-associated Ig-like receptor (LAIR)-2 antagonizes the collagen/LAIR-1 inhibitory immune interaction". J. Immunol. 180 (3): 1662–9. doi: 10.4049/jimmunol.180.3.1662 . PMID   18209062.
• Denoeud F, Kapranov P, Ucla C, et al. (2007). "Prominent use of distal 5′ transcription start sites and discovery of a large number of additional exons in ENCODE regions". Genome Res. 17 (6): 746–59. doi:10.1101/gr.5660607. PMC   1891335 . PMID   17567994.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Wende H, Volz A, Ziegler A (2000). "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster". Immunogenetics. 51 (8–9): 703–13. doi:10.1007/s002510000187. PMID   10941842. S2CID   20719684.
• Meyaard L, Hurenkamp J, Clevers H, et al. (1999). "Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells". J. Immunol. 162 (10): 5800–4. doi:10.4049/jimmunol.162.10.5800. PMID   10229813.
• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi: 10.1101/gr.6.9.807 . PMID   8889549.