FCGR2A

FCGR2A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FCG, 1H9V, 3D5O, 3RY4, 3RY5, 3RY6
Identifiers
Aliases	FCGR2A , CD32, CD32A, CDw32, FCG2, FCGR2, FCGR2A1, FcGR, IGFR2, Fc fragment of IgG receptor IIa, FcgammaRIIa, Fc gamma receptor IIa
External IDs	OMIM: 146790; MGI: 95500; HomoloGene: 47936; GeneCards: FCGR2A; OMA:FCGR2A - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q23.3 Start 161,505,430 bp [1] End 161,524,013 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1 H3|1 78.8 cM Start 170,878,743 bp [2] End 170,892,504 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood monocyte granulocyte placenta appendix right lung metanephric glomerulus spleen upper lobe of left lung gallbladder Top expressed in granulocyte stroma of bone marrow spermatocyte blood calvaria umbilical cord seminiferous tubule dermis right lung lobe tibiofemoral joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding IgG binding Cellular component integral component of membrane plasma membrane membrane secretory granule membrane cell wall Biological process Fc-gamma receptor signaling pathway involved in phagocytosis immune system process neutrophil degranulation cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2212 14131 Ensembl ENSG00000143226 ENSMUSG00000059498 UniProt P12318 P08508 RefSeq (mRNA) NM_001136219 NM_021642 NM_001375296 NM_001375297 NM_010188 NM_001356511 RefSeq (protein) NP_001129691 NP_067674 NP_001362225 NP_001362226 n/a Location (UCSC) Chr 1: 161.51 – 161.52 Mb Chr 1: 170.88 – 170.89 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Low affinity immunoglobulin gamma Fc region receptor II-a is a protein that in humans is encoded by the FCGR2A gene. ^{[5] [6]}

Interactions

FCGR2A has been shown to interact with PIK3R1 ^{[7] [8]} and Syk. ^{[8] [9]}

See also

• CD32

References

1. GRCh38: Ensembl release 89: ENSG00000143226 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000059498 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV (June 1990). "Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination". Science. 248 (4956): 732–5. Bibcode:1990Sci...248..732Q. doi:10.1126/science.2139735. PMID   2139735.
6. "Entrez Gene: FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)".
7. Chacko, G W; Brandt J T; Coggeshall K M; Anderson C L (May 1996). "Phosphoinositide 3-kinase and p72syk noncovalently associate with the low affinity Fc gamma receptor on human platelets through an immunoreceptor tyrosine-based activation motif. Reconstitution with synthetic phosphopeptides". J. Biol. Chem. 271 (18): 10775–81. doi: 10.1074/jbc.271.18.10775 . ISSN   0021-9258. PMID   8631888.
8. Ibarrola, I; Vossebeld P J; Homburg C H; Thelen M; Roos D; Verhoeven A J (July 1997). "Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa". Biochim. Biophys. Acta. 1357 (3): 348–58. doi:10.1016/S0167-4889(97)00034-7. ISSN   0006-3002. PMID   9268059.
9. Kim, M K; Pan X Q; Huang Z Y; Hunter S; Hwang P H; Indik Z K; Schreiber A D (January 2001). "Fc gamma receptors differ in their structural requirements for interaction with the tyrosine kinase Syk in the initial steps of signaling for phagocytosis". Clin. Immunol. 98 (1): 125–32. doi:10.1006/clim.2000.4955. ISSN   1521-6616. PMID   11141335.

Further reading

• McKenzie SE (2002). "Humanized mouse models of FcR clearance in immune platelet disorders". Blood Rev. 16 (1): 3–5. doi:10.1054/blre.2001.0170. PMID   11913983.
• Ernst LK, van de Winkel JG, Chiu IM, Anderson CL (1992). "Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products". J. Biol. Chem. 267 (22): 15692–700. doi: 10.1016/S0021-9258(19)49591-4 . PMID   1379234.
• Seki T (1989). "Identification of multiple isoforms of the low-affinity human IgG Fc receptor". Immunogenetics. 30 (1): 5–12. doi:10.1007/BF02421463. PMID   2526077. S2CID   23208039.
• Hessian PA, Highton J, Palmer DG (1989). "Quantification of macrophage cell surface molecules in rheumatoid arthritis". Clin. Exp. Immunol. 77 (1): 47–51. PMC   1541930 . PMID   2527651.
• Brooks DG, Qiu WQ, Luster AD, Ravetch JV (1989). "Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes". J. Exp. Med. 170 (4): 1369–85. doi:10.1084/jem.170.4.1369. PMC   2189488 . PMID   2529342.
• Lanier LL, Cwirla S, Yu G, et al. (1990). "Membrane anchoring of a human IgG Fc receptor (CD16) determined by a single amino acid". Science. 246 (4937): 1611–3. Bibcode:1989Sci...246.1611L. doi:10.1126/science.2531919. PMID   2531919.
• Stuart SG, Trounstine ML, Vaux DJ, et al. (1987). "Isolation and expression of cDNA clones encoding a human receptor for IgG (Fc gamma RII)". J. Exp. Med. 166 (6): 1668–84. doi:10.1084/jem.166.6.1668. PMC   2188792 . PMID   2824655.
• Hibbs ML, Bonadonna L, Scott BM, et al. (1988). "Molecular cloning of a human immunoglobulin G Fc receptor". Proc. Natl. Acad. Sci. U.S.A. 85 (7): 2240–4. Bibcode:1988PNAS...85.2240H. doi: 10.1073/pnas.85.7.2240 . PMC   279966 . PMID   2965389.
• Huizinga TW, van der Schoot CE, Jost C, et al. (1988). "The PI-linked receptor FcRIII is released on stimulation of neutrophils". Nature. 333 (6174): 667–9. Bibcode:1988Natur.333..667H. doi:10.1038/333667a0. PMID   2967437. S2CID   4342856.
• Sammartino L, Webber LM, Hogarth PM, et al. (1988). "Assignment of the gene coding for human FcRII (CD32) to bands q23q24 on chromosome 1". Immunogenetics. 28 (5): 380–1. doi:10.1007/BF00364238. PMID   2971615. S2CID   35705081.
• Stengelin S, Stamenkovic I, Seed B (1988). "Isolation of cDNAs for two distinct human Fc receptors by ligand affinity cloning". EMBO J. 7 (4): 1053–9. doi:10.1002/j.1460-2075.1988.tb02913.x. PMC   454434 . PMID   3402431.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Chacko GW, Brandt JT, Coggeshall KM, Anderson CL (1996). "Phosphoinositide 3-kinase and p72syk noncovalently associate with the low affinity Fc gamma receptor on human platelets through an immunoreceptor tyrosine-based activation motif. Reconstitution with synthetic phosphopeptides". J. Biol. Chem. 271 (18): 10775–81. doi: 10.1074/jbc.271.18.10775 . PMID   8631888.
• Salmon JE, Millard S, Schachter LA, et al. (1996). "Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans". J. Clin. Invest. 97 (5): 1348–54. doi:10.1172/JCI118552. PMC   507190 . PMID   8636449.
• Bewarder N, Weinrich V, Budde P, et al. (1996). "In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation". Mol. Cell. Biol. 16 (9): 4735–43. doi:10.1128/MCB.16.9.4735. PMC   231474 . PMID   8756631.
• Sármay G, Koncz G, Gergely J (1997). "Human type II Fcgamma receptors inhibit B cell activation by interacting with the p21(ras)-dependent pathway". J. Biol. Chem. 271 (48): 30499–504. doi: 10.1074/jbc.271.48.30499 . hdl: 2437/195888 . PMID   8940017.
• Ibarrola I, Vossebeld PJ, Homburg CH, et al. (1997). "Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa". Biochim. Biophys. Acta. 1357 (3): 348–58. doi:10.1016/S0167-4889(97)00034-7. PMID   9268059.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• De SK, Venkateshan CN, Seth P, et al. (1998). "Adenovirus-mediated human immunodeficiency virus-1 Nef expression in human monocytes/macrophages and effect of Nef on downmodulation of Fcgamma receptors and expression of monokines". Blood. 91 (6): 2108–17. doi: 10.1182/blood.V91.6.2108 . PMID   9490697.

External links

• FCGR2A+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.