IL18RAP

IL18RAP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3WO4
Identifiers
Aliases	IL18RAP , ACPL, CD218b, CDw218b, IL-18R-beta, IL-18RAcP, IL-18Rbeta, IL-1R-7, IL-1R7, IL-1RAcPL, IL18RB, interleukin 18 receptor accessory protein
External IDs	OMIM: 604509 MGI: 1338888 HomoloGene: 2859 GeneCards: IL18RAP
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q12.1 Start 102,418,689 bp [1] End 102,452,565 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 B Start 40,554,522 bp [2] End 40,590,865 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood bone marrow spleen cancellous bone right lung bone marrow cells upper lobe of left lung periodontal fiber appendix left uterine tube Top expressed in blood bone marrow spleen carotid body subcutaneous adipose tissue lymph node thymus respiratory system lower respiratory tract lung More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor activity interleukin-18 receptor activity Cellular component integral component of membrane membrane plasma membrane interleukin-18 receptor complex Biological process cell surface receptor signaling pathway inflammatory response immune response cellular response to cytokine stimulus signal transduction cellular response to hydrogen peroxide cell population proliferation interleukin-6 production T-helper 1 cell cytokine production neutrophil activation positive regulation of natural killer cell mediated cytotoxicity cellular response to interleukin-18 interleukin-18-mediated signaling pathway positive regulation of NF-kappaB transcription factor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8807 16174 Ensembl ENSG00000115607 ENSMUSG00000026068 UniProt O95256 Q9Z2B1 RefSeq (mRNA) NM_003853 NM_010553 RefSeq (protein) NP_003844 NP_034683 Location (UCSC) Chr 2: 102.42 – 102.45 Mb Chr 1: 40.55 – 40.59 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b (cluster of differentiation w218b), is a human gene. ^{[5] [6]}

Function

The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-κB and MAPK8 (JNK) in response to IL18. ^[5]

Disease association

Variants at IL18RAP have been linked to susceptibility to Coeliac disease. ^[7]

See also

• Interleukin-18 receptor

References

1. GRCh38: Ensembl release 89: ENSG00000115607 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026068 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: IL18RAP interleukin 18 receptor accessory protein".
6. Born TL, Thomassen E, Bird TA, Sims JE (November 1998). "Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling". J. Biol. Chem. 273 (45): 29445–50. doi: 10.1074/jbc.273.45.29445 . PMID   9792649.
7. Hunt KA, Zhernakova A, Turner G, Heap GA, Franke L, Bruinenberg M, Romanos J, Dinesen LC, Ryan AW, Panesar D, Gwilliam R, Takeuchi F, McLaren WM, Holmes GK, Howdle PD, Walters JR, Sanders DS, Playford RJ, Trynka G, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, O'Morain C, Kennedy NP, Kelleher D, Pennington DJ, Strachan DP, McArdle WL, Mein CA, Wapenaar MC, Deloukas P, McGinnis R, McManus R, Wijmenga C, van Heel DA (April 2008). "Novel celiac disease genetic determinants related to the immune response". Nat. Genet. 40 (4): 395–402. doi:10.1038/ng.102. PMC   2673512 . PMID   18311140.

Further reading

• Born TL, Thomassen E, Bird TA, Sims JE (1998). "Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling". J. Biol. Chem. 273 (45): 29445–50. doi: 10.1074/jbc.273.45.29445 . PMID   9792649.
• Sareneva T, Julkunen I, Matikainen S (2000). "IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells". J. Immunol. 165 (4): 1933–8. doi: 10.4049/jimmunol.165.4.1933 . PMID   10925275.
• Mee JB, Alam Y, Groves RW (2000). "Human keratinocytes constitutively produce but do not process interleukin-18". Br. J. Dermatol. 143 (2): 330–6. doi:10.1046/j.1365-2133.2000.03759.x. PMID   10951141. S2CID   44747360.
• Debets R, Timans JC, Churakowa T, et al. (2000). "IL-18 receptors, their role in ligand binding and function: anti-IL-1RAcPL antibody, a potent antagonist of IL-18". J. Immunol. 165 (9): 4950–6. doi: 10.4049/jimmunol.165.9.4950 . PMID   11046021.
• Salvati VM, MacDonald TT, Bajaj-Elliott M, et al. (2002). "Interleukin 18 and associated markers of T helper cell type 1 activity in coeliac disease". Gut. 50 (2): 186–90. doi:10.1136/gut.50.2.186. PMC   1773110 . PMID   11788557.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Fukushima K, Ikehara Y, Yamashita K (2005). "Functional role played by the glycosylphosphatidylinositol anchor glycan of CD48 in interleukin-18-induced interferon-gamma production". J. Biol. Chem. 280 (18): 18056–62. doi: 10.1074/jbc.M413297200 . PMID   15760905.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi: 10.1038/nature03466 . PMID   15815621.
• Fiszer D, Rozwadowska N, Rychlewski L, et al. (2008). "Identification of IL-18RAP mRNA truncated splice variants in human testis and the other human tissues". Cytokine. 39 (3): 178–83. doi:10.1016/j.cyto.2007.07.186. PMID   17897836.

External links

• IL18RAP+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.