SIRPG

SIRPG
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2JJW, 4I2X
Identifiers
Aliases	SIRPG , CD172g, SIRP-B2, SIRPB2, SIRPgamma, bA77C3.1, signal regulatory protein gamma
External IDs	OMIM: 605466 HomoloGene: 56809 GeneCards: SIRPG
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20p13 Start 1,629,152 bp [1] End 1,657,779 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lymph node blood appendix spleen thymus rectum bone marrow cells gallbladder pharynx thymus n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane plasma membrane membrane intracellular anatomical structure Biological process cell-cell signaling cell adhesion intracellular signal transduction positive regulation of T cell activation leukocyte migration positive regulation of cell population proliferation negative regulation of cell population proliferation positive regulation of cell-cell adhesion positive regulation of phagocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55423 n/a Ensembl ENSG00000089012 n/a UniProt Q9P1W8 n/a RefSeq (mRNA) NM_001039508 NM_018556 NM_080816 n/a RefSeq (protein) NP_001034597 NP_061026 NP_543006 n/a Location (UCSC) Chr 20: 1.63 – 1.66 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Signal-regulatory protein gamma is a protein that in humans is encoded by the SIRPG gene. ^{[3] [4] [5]} SIRPG has also recently been designated CD172G (cluster of differentiation 172G).

The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000089012 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Ichigotani Y, Matsuda S, Machida K, Oshima K, Iwamoto T, Yamaki K, Hayakawa T, Hamaguchi M (Jan 2001). "Molecular cloning of a novel human gene (SIRP-B2) which encodes a new member of the SIRP/SHPS-1 protein family". J Hum Genet. 45 (6): 378–82. doi: 10.1007/s100380070013 . PMID   11185750.
4. van den Berg TK, van Beek EM, Buhring HJ, Colonna M, Hamaguchi M, Howard CJ, Kasuga M, Liu Y, Matozaki T, Neel BG, Parkos CA, Sano S, Vignery A, Vivier E, Wright M, Zawatzky R, Barclay AN (Dec 2005). "A nomenclature for signal regulatory protein family members". J Immunol. 175 (12): 7788–9. doi: 10.4049/jimmunol.175.12.7788 . PMID   16339511.
5. "Entrez Gene: SIRPG signal-regulatory protein gamma".

Further reading

• Kharitonenkov A, Chen Z, Sures I, et al. (1997). "A family of proteins that inhibit signalling through tyrosine kinase receptors". Nature. 386 (6621): 181–6. Bibcode:1997Natur.386..181K. doi:10.1038/386181a0. PMID   9062191. S2CID   4259314.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Brooke G, Holbrook JD, Brown MH, Barclay AN (2004). "Human lymphocytes interact directly with CD47 through a novel member of the signal regulatory protein (SIRP) family". J. Immunol. 173 (4): 2562–70. doi: 10.4049/jimmunol.173.4.2562 . PMID   15294972.
• Piccio L, Vermi W, Boles KS, et al. (2006). "Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation". Blood. 105 (6): 2421–7. doi: 10.1182/blood-2004-07-2823 . PMID   15383453.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Signal-regulatory protein gamma (SIRPG)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.