CCR4

Last updated
CCR4
Identifiers
Aliases CCR4 , CC-CKR-4, CD194, CKR4, CMKBR4, ChemR13, HGCN:14099, K5-5, C-C motif chemokine receptor 4
External IDs OMIM: 604836; MGI: 107824; HomoloGene: 21135; GeneCards: CCR4; OMA:CCR4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

1233

12773

Ensembl

ENSG00000183813

ENSMUSG00000047898

UniProt

P51679

P51680

RefSeq (mRNA)

NM_005508

NM_009916

RefSeq (protein)

NP_005499

NP_034046

Location (UCSC) Chr 3: 32.95 – 32.96 Mb Chr 9: 114.32 – 114.33 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

C-C chemokine receptor type 4 is a protein that in humans is encoded by the CCR4 gene. [5] [6] [7] CCR4 has also recently been designated CD194 (cluster of differentiation 194).

Contents

The protein encoded by this gene belongs to the G protein-coupled receptor family. It is a receptor for the following CC chemokines:

Chemokines are a group of small structurally related proteins that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. [7]

CCR4 is a cell-surface protein and should not be confused with the unrelated carbon catabolite repression-negative on TATA-less (CCR4-Not), a nuclear protein complex that regulates gene expression.

Clinical significance

CCR4 is often expressed on leukemic cells in cutaneous T-cell lymphoma (CTCL). [10]

As a drug target

Mogamulizumab is a humanised monoclonal antibody targeted at CCR4 and is an investigational drug for CTCL. [10]

Related Research Articles

<span class="mw-page-title-main">CCL3</span> Mammalian protein found in Homo sapiens

Chemokine ligand 3 (CCL3) also known as macrophage inflammatory protein 1-alpha (MIP-1-alpha) is a protein that in humans is encoded by the CCL3 gene.

<span class="mw-page-title-main">CCL20</span> Mammalian protein found in Homo sapiens

Chemokine ligand 20 (CCL20) or liver activation regulated chemokine (LARC) or Macrophage Inflammatory Protein-3 (MIP3A) is a small cytokine belonging to the CC chemokine family. It is strongly chemotactic for lymphocytes and weakly attracts neutrophils. CCL20 is implicated in the formation and function of mucosal lymphoid tissues via chemoattraction of lymphocytes and dendritic cells towards the epithelial cells surrounding these tissues. CCL20 elicits its effects on its target cells by binding and activating the chemokine receptor CCR6.

<span class="mw-page-title-main">CCL21</span> Mammalian protein found in Homo sapiens

Chemokine ligand 21 (CCL21) is a small cytokine belonging to the CC chemokine family. This chemokine is also known as 6Ckine, exodus-2, and secondary lymphoid-tissue chemokine (SLC). CCL21 elicits its effects by binding to a cell surface chemokine receptor known as CCR7. The main function of CCL21 is to guide CCR7 expressing leukocytes to the secondary lymphoid organs, such as lymph nodes and Peyer´s patches.

<span class="mw-page-title-main">CCL22</span> Mammalian protein found in Homo sapiens

C-C motif chemokine 22 is a protein that in humans is encoded by the CCL22 gene.

<span class="mw-page-title-main">CCL17</span> Mammalian protein found in Homo sapiens

CCL17 is a powerful chemokine produced in the thymus and by antigen-presenting cells like dendritic cells, macrophages, and monocytes. CCL17 plays a complex role in cancer. It attracts T-regulatory cells allowing for some cancers to evade an immune response. However, in other cancers, such as melanoma, an increase in CCL17 is linked to an improved outcome. CCL17 has also been linked to autoimmune and allergic diseases.

<span class="mw-page-title-main">CX3CL1</span> Protein-coding gene in the species Homo sapiens

Fractalkine, also known as chemokine ligand 1, is a protein that in humans is encoded by the CX3CL1 gene.

<span class="mw-page-title-main">CCL19</span> Mammalian protein found in Homo sapiens

Chemokine ligand 19 (CCL19) is a protein that in humans is encoded by the CCL19 gene.

<span class="mw-page-title-main">XCR1</span> Protein-coding gene in the species Homo sapiens

The "C" sub-family of chemokine receptors contains only one member: XCR1, the receptor for XCL1 and XCL2.

CC chemokine receptors are integral membrane proteins that specifically bind and respond to cytokines of the CC chemokine family. They represent one subfamily of chemokine receptors, a large family of G protein-linked receptors that are known as seven transmembrane (7-TM) proteins since they span the cell membrane seven times. To date, ten true members of the CC chemokine receptor subfamily have been described. These are named CCR1 to CCR10 according to the IUIS/WHO Subcommittee on Chemokine Nomenclature.

<span class="mw-page-title-main">XCL1</span> Protein-coding gene in the species Homo sapiens

Chemokine ligand (XCL1) is a small cytokine belonging to the C chemokine family that is also known as lymphotactin. Chemokines are known for their function in inflammatory and immunological responses. This family C chemokines differs in structure and function from most chemokines. There are only two chemokines in this family and what separated them from other chemokines is that they only have two cysteines; one N-terminal cysteine and one cysteine downstream. These both are called Lymphotactin, alpha and beta form, and claim special characteristics only found between the two. Lymphotactins can go through a reversible conformational change which changes its binding shifts.

<span class="mw-page-title-main">XCL2</span> Protein-coding gene in the species Homo sapiens

Chemokine ligand 2 (XCL2) is a small cytokine belonging to the XC chemokine family that is highly related to another chemokine called XCL1. It is predominantly expressed in activated T cells, but can also be found at low levels in unstimulated cells. XCL2 induces chemotaxis of cells expressing the chemokine receptor XCR1. Its gene is located on chromosome 1 in humans.

<span class="mw-page-title-main">CCR1</span> Protein in humans

C-C chemokine receptor type 1 is a protein that in humans is encoded by the CCR1 gene.

<span class="mw-page-title-main">C-C chemokine receptor type 6</span> Mammalian protein found in Homo sapiens

Chemokine receptor 6 also known as CCR6 is a CC chemokine receptor protein which in humans is encoded by the CCR6 gene. CCR6 has also recently been designated CD196. The gene is located on the long arm of Chromosome 6 (6q27) on the Watson (plus) strand. It is 139,737 bases long and encodes a protein of 374 amino acids.

<span class="mw-page-title-main">CCR10</span> Protein-coding gene in the species Homo sapiens

C-C chemokine receptor type 10 is a protein that in humans is encoded by the CCR10 gene.

<span class="mw-page-title-main">CCR3 (gene)</span> Protein-coding gene in humans

C-C chemokine receptor type 3 is a protein that in humans is encoded by the CCR3 gene.

<span class="mw-page-title-main">CCR8 (gene)</span> Protein-coding gene in the species Homo sapiens

Chemokine receptor 8, also known as CCR8, is a protein which in humans is encoded by the CCR8 gene. CCR8 has also recently been designated CDw198.

<span class="mw-page-title-main">CCBP2</span> Protein-coding gene in the species Homo sapiens

Chemokine-binding protein 2 is a protein that in humans is encoded by the CCBP2 gene.

C-C motif chemokine 4-like is a protein that in humans is encoded by the CCL4L1 gene.

<span class="mw-page-title-main">IFNAR1</span> Protein-coding gene in the species Homo sapiens

Interferon-alpha/beta receptor alpha chain is a protein that in humans is encoded by the IFNAR1 gene.

<span class="mw-page-title-main">C-C motif chemokine ligand 27</span> Mammalian protein found in Homo sapiens

C-C motif chemokine ligand 27 is a protein that in humans is encoded by the CCL27 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000183813 – Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047898 – Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Power CA, Meyer A, Nemeth K, Bacon KB, Hoogewerf AJ, Proudfoot AE, Wells TN (Sep 1995). "Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line". J Biol Chem. 270 (33): 19495–500. doi: 10.1074/jbc.270.33.19495 . PMID   7642634.
  6. ↑ Samson M, Soularue P, Vassart G, Parmentier M (Feb 1997). "The genes encoding the human CC-chemokine receptors CC-CKR1 to CC-CKR5 (CMKBR1-CMKBR5) are clustered in the p21.3-p24 region of chromosome 3". Genomics. 36 (3): 522–6. doi:10.1006/geno.1996.0498. PMID   8884276.
  7. 1 2 "Entrez Gene: CCR4 chemokine (C-C motif) receptor 4".
  8. ↑ Imai T, Baba M, Nishimura M, Kakizaki M, Takagi S, Yoshie O (June 1997). "The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4". J. Biol. Chem. 272 (23): 15036–42. doi: 10.1074/jbc.272.23.15036 . PMID   9169480.
  9. ↑ Imai T, Chantry D, Raport CJ, Wood CL, Nishimura M, Godiska R, Yoshie O, Gray PW (January 1998). "Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4". J. Biol. Chem. 273 (3): 1764–8. doi: 10.1074/jbc.273.3.1764 . PMID   9430724.
  10. 1 2 FDA grants priority review to mogamulizumab for cutaneous T-cell lymphoma Nov 2017


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