CCR4

Last updated
CCR4
Identifiers
Aliases CCR4 , CC-CKR-4, CD194, CKR4, CMKBR4, ChemR13, HGCN:14099, K5-5, C-C motif chemokine receptor 4
External IDs OMIM: 604836 MGI: 107824 HomoloGene: 21135 GeneCards: CCR4
Orthologs
SpeciesHumanMouse
Entrez

1233

12773

Ensembl

ENSG00000183813

ENSMUSG00000047898

UniProt

P51679

P51680

RefSeq (mRNA)

NM_005508

NM_009916

RefSeq (protein)

NP_005499

NP_034046

Location (UCSC) Chr 3: 32.95 – 32.96 Mb Chr 9: 114.49 – 114.5 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

C-C chemokine receptor type 4 is a protein that in humans is encoded by the CCR4 gene. [5] [6] [7] CCR4 has also recently been designated CD194 (cluster of differentiation 194).

Contents

The protein encoded by this gene belongs to the G protein-coupled receptor family. It is a receptor for the following CC chemokines:

Chemokines are a group of small structurally related proteins that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. [7]

CCR4 and CAF-1 form a deadenylase complex. The complex cooperates with the release factor eRF3 and PABPC1 to shorten the poly(A) tail of mRNA during translation. [10]

Clinical significance

CCR4 is often expressed on leukemic cells in cutaneous T-cell lymphoma (CTCL). [11]

As a drug target

Mogamulizumab is a humanised monoclonal antibody targeted at CCR4 and is an investigational drug for CTCL. [11]

Related Research Articles

CCL5

Chemokine ligand 5 is a protein which in humans is encoded by the CCL5 gene. It is also known as RANTES.

CCL8

Chemokine ligand 8 (CCL8), also known as monocyte chemoattractant protein 2 (MCP2), is a protein that in humans is encoded by the CCL8 gene.

CCL11

C-C motif chemokine 11 also known as eosinophil chemotactic protein and eotaxin-1 is a protein that in humans is encoded by the CCL11 gene. This gene is encoded on three exons and is located on chromosome 17.

CCL20

Chemokine ligand 20 (CCL20) or liver activation regulated chemokine (LARC) or Macrophage Inflammatory Protein-3 (MIP3A) is a small cytokine belonging to the CC chemokine family. It is strongly chemotactic for lymphocytes and weakly attracts neutrophils. CCL20 is implicated in the formation and function of mucosal lymphoid tissues via chemoattraction of lymphocytes and dendritic cells towards the epithelial cells surrounding these tissues. CCL20 elicits its effects on its target cells by binding and activating the chemokine receptor CCR6.

CCL21

Chemokine ligand 21 (CCL21) is a small cytokine belonging to the CC chemokine family. This chemokine is also known as 6Ckine, exodus-2, and secondary lymphoid-tissue chemokine (SLC). The gene for CCL21 is located on human chromosome 9. CCL21 elicits its effects by binding to a cell surface chemokine receptor known as CCR7.

CCL22

C-C motif chemokine 22 is a protein that in humans is encoded by the CCL22 gene.

CCL17

CCL17 is a powerful chemokine produced in the thymus and by antigen-presenting cells like dendritic cells, macrophages, and monocytes. CCL17 plays a complex role in cancer. It attracts T-regulatory cells allowing for some cancers to evade an immune response. However, in other cancers, such as melanoma, an increase in CCL17 is linked to an improved outcome. CCL17 has also been linked to allergic diseases.

CCL19

Chemokine ligand 19 (CCL19) is a protein that in humans is encoded by the CCL19 gene.

CC chemokine receptors are integral membrane proteins that specifically bind and respond to cytokines of the CC chemokine family. They represent one subfamily of chemokine receptors, a large family of G protein-linked receptors that are known as seven transmembrane (7-TM) proteins since they span the cell membrane seven times. To date, ten true members of the CC chemokine receptor subfamily have been described. These are named CCR1 to CCR10 according to the IUIS/WHO Subcommittee on Chemokine Nomenclature.

CCR2

C-C chemokine receptor type 2 (CCR2 or CD192 is a protein that in humans is encoded by the CCR2 gene. CCR2 is a CC chemokine receptor.

C-C chemokine receptor type 7

C-C chemokine receptor type 7 is a protein that in humans is encoded by the CCR7 gene. Two ligands have been identified for this receptor: the chemokines ligand 19 (CCL19/ELC) and ligand 21 (CCL21).

CCR1

C-C chemokine receptor type 1 is a protein that in humans is encoded by the CCR1 gene.

C-C chemokine receptor type 6

Chemokine receptor 6 also known as CCR6 is a CC chemokine receptor protein which in humans is encoded by the CCR6 gene. CCR6 has also recently been designated CD196. The gene is located on the long arm of Chromosome 6 (6q27) on the Watson (plus) strand. It is 139,737 bases long and encodes a protein of 374 amino acids.

CCR10

C-C chemokine receptor type 10 is a protein that in humans is encoded by the CCR10 gene.

CCR3 (gene)

C-C chemokine receptor type 3 is a protein that in humans is encoded by the CCR3 gene.

CCR8 (gene)

Chemokine receptor 8, also known as CCR8, is a protein which in humans is encoded by the CCR8 gene. CCR8 has also recently been designated CDw198.

CCRL1

C-C chemokine receptor type 11 is a protein that in humans is encoded by the CCRL1 gene.

CCBP2

Chemokine-binding protein 2 is a protein that in humans is encoded by the CCBP2 gene.

CCL4L1

C-C motif chemokine 4-like is a protein that in humans is encoded by the CCL4L1 gene.

C-c motif chemokine ligand 27

C-C motif chemokine ligand 27 is a protein that in humans is encoded by the CCL27 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000183813 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047898 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Power CA, Meyer A, Nemeth K, Bacon KB, Hoogewerf AJ, Proudfoot AE, Wells TN (Sep 1995). "Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line". J Biol Chem. 270 (33): 19495–500. doi: 10.1074/jbc.270.33.19495 . PMID   7642634.
  6. ↑ Samson M, Soularue P, Vassart G, Parmentier M (Feb 1997). "The genes encoding the human CC-chemokine receptors CC-CKR1 to CC-CKR5 (CMKBR1-CMKBR5) are clustered in the p21.3-p24 region of chromosome 3". Genomics. 36 (3): 522–6. doi:10.1006/geno.1996.0498. PMID   8884276.
  7. 1 2 "Entrez Gene: CCR4 chemokine (C-C motif) receptor 4".
  8. ↑ Imai T, Baba M, Nishimura M, Kakizaki M, Takagi S, Yoshie O (June 1997). "The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4". J. Biol. Chem. 272 (23): 15036–42. doi: 10.1074/jbc.272.23.15036 . PMID   9169480.
  9. ↑ Imai T, Chantry D, Raport CJ, Wood CL, Nishimura M, Godiska R, Yoshie O, Gray PW (January 1998). "Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4". J. Biol. Chem. 273 (3): 1764–8. doi: 10.1074/jbc.273.3.1764 . PMID   9430724.
  10. ↑ Funakoshi Y, Doi Y, Hosoda N, Uchida N, Osawa M, Shimada I, et al. (December 2007). "Mechanism of mRNA deadenylation: evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylases". Genes & Development. 21 (23): 3135–48. doi:10.1101/gad.1597707. PMC   2081979 . PMID   18056425.
  11. 1 2 FDA grants priority review to mogamulizumab for cutaneous T-cell lymphoma Nov 2017


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