IGLL1

IGLL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2H32, 2H3N, 2LKQ
Identifiers
Aliases	IGLL1 , 14.1, AGM2, CD179b, IGL1, IGL5, IGLJ14.1, IGLL, IGO, IGVPB, VPREB2, immunoglobulin lambda like polypeptide 1
External IDs	OMIM: 146770 MGI: 96529 HomoloGene: 131669 GeneCards: IGLL1
Gene location (Human)
Chr.	Chromosome 22 (human)
End	23,580,302 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	16,681,849 bp
RNA expression pattern
	Top expressed in
	bone marrow; ; bone marrow cells; ; cancellous bone; ; thymus; ; monocyte; ; lymph node; ; spleen; ; blood; ; duodenum; ; thymus;
	Top expressed in
	bone marrow; ; choroid plexus; ; brown adipose tissue; ; Region I of hippocampus proper; ; inferior colliculus; ; secondary oocyte; ; gland; ; exocrine gland; ; foregut; ; endocrine gland;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	immunoglobulin receptor binding ; antigen binding ;
Cellular component	blood microparticle ; membrane ; external side of plasma membrane ; immunoglobulin complex, circulating ; extracellular region ;
Biological process	B cell receptor signaling pathway ; phagocytosis, recognition ; positive regulation of B cell activation ; phagocytosis, engulfment ; innate immune response ; defense response to bacterium ; immune response ; complement activation, classical pathway ; leukocyte migration ;
	Sources:Amigo / QuickGO
Orthologs
	3543
	16136
	ENSG00000128322
	ENSMUSG00000075370
	P15814
	P20764
	NM_020070 ; NM_152855 ; NM_001369906
	NM_001190325
	NP_064455 ; NP_690594 ; NP_001356835
	NP_001177254
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 05, 2023

Immunoglobulin lambda-like polypeptide 1 is a protein that in humans is encoded by the IGLL1 gene.^[5]^[6]^[7] IGLL1 has also recently been designated CD179B (cluster of differentiation 179B).

It is associated with agammaglobulinemia-2.

The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene.^[7]

Related Research Articles

Immunoglobulin M (IgM) is one of several isotypes of antibody that are produced by vertebrates. IgM is the largest antibody, and it is the first antibody to appear in the response to initial exposure to an antigen. In humans and other mammals that have been studied, plasmablasts residing in the spleen are the main source for specific IgM production.

Immunoglobulin class switching, also known as isotype switching, isotypic commutation or class-switch recombination (CSR), is a biological mechanism that changes a B cell's production of immunoglobulin from one type to another, such as from the isotype IgM to the isotype IgG. During this process, the constant-region portion of the antibody heavy chain is changed, but the variable region of the heavy chain stays the same. Since the variable region does not change, class switching does not affect antigen specificity. Instead, the antibody retains affinity for the same antigens, but can interact with different effector molecules.

A J chain is a protein component of the antibodies IgM and IgA. It is a 137 residue polypeptide, encoded by the IGJ gene.

Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide, also known as FCER1A, is a protein which in humans is encoded by the FCER1A gene.

Poliovirus receptor-related 2 (PVRL2), also known as nectin-2 and CD112, is a human plasma membrane glycoprotein.

Killer cell immunoglobulin-like receptor 3DL1 is a protein that in humans is encoded by the KIR3DL1 gene.

<span class="mw-page-title-main">IGHM</span> Gene in the species Homo sapiens

Ig mu chain C region is a protein that in humans is encoded by the IGHM gene.

Immunoglobulin heavy locus, also known as IGH, is a region on human chromosome 14 that contains a gene for the heavy chains of human antibodies.

Ig delta chain C region is a protein that in humans is encoded by the IGHD gene.

Immunoglobulin lambda locus, also known as IGL@, is a region on the q arm of human chromosome 22, region 11.22 (22q11.22) that contains genes for the lambda light chains of antibodies.

Immunoglobulin iota chain is a protein that in humans is encoded by the VPREB1 gene. VPREB1 has also recently been designated CD179A.

Leukocyte immunoglobulin-like receptor subfamily B member 3 is a protein that in humans is encoded by the LILRB3 gene.

Ig heavy chain V-III region VH26 is a protein that in humans is encoded by the IGHV@ gene.

Pre-B lymphocyte protein 3 is a protein that in humans is encoded by the VPREB3 gene.

Cluster of differentiation CD79A also known as B-cell antigen receptor complex-associated protein alpha chain and MB-1 membrane glycoprotein, is a protein that in humans is encoded by the CD79A gene.

CD79b molecule, immunoglobulin-associated beta, also known as CD79B, is a human gene.

High affinity immunoglobulin gamma Fc receptor I is a protein that in humans is encoded by the FCGR1A gene.

T-cell surface glycoprotein CD3 delta chain is a protein that in humans is encoded by the CD3D gene.

High affinity immunoglobulin epsilon receptor subunit beta is a protein that in humans is encoded by the MS4A2 gene.

Leukocyte immunoglobulin-like receptor subfamily A member 4 is a protein that in humans is encoded by the LILRA4 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000128322 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000075370 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Bauer SR, Huebner K, Budarf M, Finan J, Erikson J, Emanuel BS, Nowell PC, Croce CM, Melchers F (Nov 1988). "The human Vpre B gene is located on chromosome 22 near a cluster of V lambda gene segments". Immunogenetics. 28 (5): 328–33. doi:10.1007/BF00364231. PMID 3139558. S2CID 6981867.
↑ Schiff C, Milili M, Fougereau M (Dec 1989). "Isolation of early immunoglobulin lambda-like gene transcripts in human fetal liver". Eur J Immunol. 19 (10): 1873–8. doi:10.1002/eji.1830191018. PMID 2511029. S2CID 84544002.
1 2 "Entrez Gene: IGLL1 immunoglobulin lambda-like polypeptide 1".

Evans RJ, Hollis GF (1991). "Genomic structure of the human Ig lambda 1 gene suggests that it may be expressed as an Ig lambda 14.1-like protein or as a canonical B cell Ig lambda light chain: implications for Ig lambda gene evolution". J. Exp. Med. 173 (2): 305–11. doi:10.1084/jem.173.2.305. PMC 2118775 . PMID 1703205.
Bossy D, Milili M, Zucman J, et al. (1992). "Organization and expression of the lambda-like genes that contribute to the mu-psi light chain complex in human pre-B cells". Int. Immunol. 3 (11): 1081–90. doi:10.1093/intimm/3.11.1081. PMID 1760403.
Mattei MG, Fumoux F, Roeckel N, et al. (1991). "The human pre-B-specific lambda-like cluster is located in the 22q11.2-22q12.3 region, distal to the IgC lambda locus". Genomics. 9 (3): 544–6. doi:10.1016/0888-7543(91)90422-B. PMID 1903358.
Tsubata T, Reth M (1990). "The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface". J. Exp. Med. 172 (3): 973–6. doi:10.1084/jem.172.3.973. PMC 2188549 . PMID 2117639.
Schiff C, Bensmana M, Guglielmi P, et al. (1991). "The immunoglobulin lambda-like gene cluster (14.1, 16.1 and F lambda 1) contains gene(s) selectively expressed in pre-B cells and is the human counterpart of the mouse lambda 5 gene". Int. Immunol. 2 (3): 201–7. doi:10.1093/intimm/2.3.201. PMID 2128466.
Hollis GF, Evans RJ, Stafford-Hollis JM, et al. (1989). "Immunoglobulin lambda light-chain-related genes 14.1 and 16.1 are expressed in pre-B cells and may encode the human immunoglobulin omega light-chain protein". Proc. Natl. Acad. Sci. U.S.A. 86 (14): 5552–6. Bibcode:1989PNAS...86.5552H. doi: 10.1073/pnas.86.14.5552 . PMC 297661 . PMID 2501791.
Chang H, Dmitrovsky E, Hieter PA, et al. (1986). "Identification of three new Ig lambda-like genes in man". J. Exp. Med. 163 (2): 425–35. doi:10.1084/jem.163.2.425. PMC 2188038 . PMID 3003227.
Ohnishi K, Takemori T (1994). "Molecular components and assembly of mu.surrogate light chain complexes in pre-B cell lines". J. Biol. Chem. 269 (45): 28347–53. doi: 10.1016/S0021-9258(18)46934-7 . PMID 7961773.
Bauer TR, McDermid HE, Budarf ML, et al. (1993). "Physical location of the human immunoglobulin lambda-like genes, 14.1, 16.1, and 16.2" (PDF). Immunogenetics. 38 (6): 387–99. doi:10.1007/BF00184519. hdl: 2027.42/46751 . PMID 8406611. S2CID 19311673.
Sohi MK, Corper AL, Wan T, et al. (1996). "Crystallization of a complex between the Fab fragment of a human immunoglobulin M (IgM) rheumatoid factor (RF-AN) and the Fc fragment of human IgG4". Immunology. 88 (4): 636–41. doi:10.1046/j.1365-2567.1996.d01-692.x. PMC 1456622 . PMID 8881769.
Donohoe ME, Blomberg BB (1997). "The 14.1 surrogate light chain promoter has lineage- and stage-restricted activity". J. Immunol. 158 (4): 1681–91. PMID 9029104.
Kawasaki K, Minoshima S, Nakato E, et al. (1997). "One-megabase sequence analysis of the human immunoglobulin lambda gene locus". Genome Res. 7 (3): 250–61. doi: 10.1101/gr.7.3.250 . PMID 9074928.
Corper AL, Sohi MK, Bonagura VR, et al. (1997). "Structure of human IgM rheumatoid factor Fab bound to its autoantigen IgG Fc reveals a novel topology of antibody-antigen interaction". Nat. Struct. Biol. 4 (5): 374–81. doi:10.1038/nsb0597-374. PMID 9145108. S2CID 34331252.
Minegishi Y, Coustan-Smith E, Wang YH, et al. (1998). "Mutations in the Human λ5/14.1 Gene Result in B Cell Deficiency and Agammaglobulinemia". J. Exp. Med. 187 (1): 71–7. doi:10.1084/jem.187.1.71. PMC 2199185 . PMID 9419212.
Miyazaki T, Kato I, Takeshita S, et al. (1999). "Lambda5 is required for rearrangement of the Ig kappa light chain gene in pro-B cell lines". Int. Immunol. 11 (8): 1195–202. doi: 10.1093/intimm/11.8.1195 . PMID 10421777.
Donohoe ME, Beck-Engeser GB, Lonberg N, et al. (2000). "Transgenic human lambda 5 rescues the murine lambda 5 nullizygous phenotype". J. Immunol. 164 (10): 5269–76. doi: 10.4049/jimmunol.164.10.5269 . PMID 10799888.
Nomura K, Kanegane H, Karasuyama H, et al. (2000). "Genetic defect in human X-linked agammaglobulinemia impedes a maturational evolution of pro-B cells into a later stage of pre-B cells in the B-cell differentiation pathway". Blood. 96 (2): 610–7. PMID 10887125.
Fang T, Smith BP, Roman CA (2001). "Conventional and surrogate light chains differentially regulate Ig mu and Dmu heavy chain maturation and surface expression". J. Immunol. 167 (7): 3846–57. doi: 10.4049/jimmunol.167.7.3846 . PMID 11564802.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000128322 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000075370 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3139558-5] Bauer SR, Huebner K, Budarf M, Finan J, Erikson J, Emanuel BS, Nowell PC, Croce CM, Melchers F (Nov 1988). "The human Vpre B gene is located on chromosome 22 near a cluster of V lambda gene segments". Immunogenetics. 28 (5): 328–33. doi:10.1007/BF00364231. PMID 3139558. S2CID 6981867.

[pmid2511029-6] Schiff C, Milili M, Fougereau M (Dec 1989). "Isolation of early immunoglobulin lambda-like gene transcripts in human fetal liver". Eur J Immunol. 19 (10): 1873–8. doi:10.1002/eji.1830191018. PMID 2511029. S2CID 84544002.

[entrez-7] 1 2 "Entrez Gene: IGLL1 immunoglobulin lambda-like polypeptide 1".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

v t e Antibodies
Main types	IgA IgD IgE IgG IgM IgY
Chains	Light chain IGK@ IGL@ surrogate IGLL1 Heavy chain IGH@ IGHM Heavy-chain antibody/IgNAR

IGLL1

Related Research Articles

References

Further reading