IL2RB

IL2RB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2B5I, 2ERJ, 3QAZ, 4GS7
Identifiers
Aliases	IL2RB , CD122, IL15RB, P70-75, interleukin 2 receptor subunit beta, IMD63
External IDs	OMIM: 146710; MGI: 96550; HomoloGene: 47955; GeneCards: IL2RB; OMA:IL2RB - orthologs
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q12.3 Start 37,125,843 bp [1] End 37,175,054 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15 E1|15 37.52 cM Start 78,363,456 bp [2] End 78,379,471 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte decidua mucosa of ileum blood lymph node spleen appendix bone marrow cells mucosa of urinary bladder epithelium of nasopharynx Top expressed in mesenteric lymph nodes blood decidua spleen secondary oocyte gastrula zygote thymus pharynx lumbar subsegment of spinal cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function interleukin-2 binding protein binding cytokine receptor activity interleukin-2 receptor activity interleukin-15 receptor activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane external side of plasma membrane endosome cytosol interleukin-2 receptor complex cell surface Biological process negative regulation of apoptotic process MAPK cascade interleukin-2-mediated signaling pathway viral process signal transduction cytokine-mediated signaling pathway interleukin-15-mediated signaling pathway regulation of molecular function positive regulation of phagocytosis protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3560 16185 Ensembl ENSG00000100385 ENSMUSG00000068227 UniProt P14784 P16297 RefSeq (mRNA) NM_000878 NM_001346222 NM_001346223 NM_008368 RefSeq (protein) NP_000869 NP_001333151 NP_001333152 NP_032394 Location (UCSC) Chr 22: 37.13 – 37.18 Mb Chr 15: 78.36 – 78.38 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interleukin-2 receptor subunit beta is a protein that in humans is encoded by the IL2RB gene. ^[5] Also known as CD122; IL15RB; P70-75. ^[5]

Function

The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit (also called CD25) and is not involved in signal transduction. The intermediate affinity form consists of a gamma/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. ^[5]

This protein also forms one of the three subunits of the IL-15 receptor.

Activation of the receptor increases proliferation of CD8+ effector T cells. ^[6]

Interactions

IL2RB has been shown to interact with:

• CISH, ^[7]
• HGS, ^[8]
• Janus kinase 1, ^{[9] [10] [11] [12] [13]} and
• SHC1. ^{[14] [15]}

See also

• IL-2 receptor
• IL-15 receptor

References

1. GRCh38: Ensembl release 89: ENSG00000100385 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000068227 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: IL2RB interleukin 2 receptor, beta".
6. Boyman O, Sprent J (February 17, 2012). "The role of interleukin-2 during homeostasis and activation of the immune system". Nat Rev Immunol. 12 (3): 180–190. doi:10.1038/nri3156. PMID   22343569. S2CID   22680847.
7. Aman MJ, Migone TS, Sasaki A, Ascherman DP, Zhu Mh, Soldaini E, Imada K, Miyajima A, Yoshimura A, Leonard WJ (October 1999). "CIS associates with the interleukin-2 receptor beta chain and inhibits interleukin-2-dependent signaling". J. Biol. Chem. 274 (42): 30266–72. doi: 10.1074/jbc.274.42.30266 . PMID   10514520.
8. Yamashita Y, Kojima K, Tsukahara T, Agawa H, Yamada K, Amano Y, Kurotori N, Tanaka N, Sugamura K, Takeshita T (May 2008). "Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin-2 receptor beta-chain". J. Cell Sci. 121 (Pt 10): 1727–38. doi: 10.1242/jcs.024455 . PMID   18445679.
9. Miyazaki T, Kawahara A, Fujii H, Nakagawa Y, Minami Y, Liu ZJ, Oishi I, Silvennoinen O, Witthuhn BA, Ihle JN (November 1994). "Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits". Science. 266 (5187): 1045–7. Bibcode:1994Sci...266.1045M. doi:10.1126/science.7973659. PMID   7973659.
10. Russell SM, Johnston JA, Noguchi M, Kawamura M, Bacon CM, Friedmann M, Berg M, McVicar DW, Witthuhn BA, Silvennoinen O (November 1994). "Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID". Science. 266 (5187): 1042–5. Bibcode:1994Sci...266.1042R. doi:10.1126/science.7973658. PMID   7973658.
11. Usacheva A, Kotenko S, Witte MM, Colamonici OR (August 2002). "Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors". J. Immunol. 169 (3): 1302–8. doi: 10.4049/jimmunol.169.3.1302 . PMID   12133952.
12. Zhu MH, Berry JA, Russell SM, Leonard WJ (April 1998). "Delineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to Il-2Rbeta". J. Biol. Chem. 273 (17): 10719–25. doi: 10.1074/jbc.273.17.10719 . PMID   9553136.
13. Migone TS, Rodig S, Cacalano NA, Berg M, Schreiber RD, Leonard WJ (November 1998). "Functional cooperation of the interleukin-2 receptor beta chain and Jak1 in phosphatidylinositol 3-kinase recruitment and phosphorylation". Mol. Cell. Biol. 18 (11): 6416–22. doi:10.1128/mcb.18.11.6416. PMC   109227 . PMID   9774657.
14. Delespine-Carmagnat M, Bouvier G, Bertoglio J (January 2000). "Association of STAT1, STAT3 and STAT5 proteins with the IL-2 receptor involves different subdomains of the IL-2 receptor beta chain". Eur. J. Immunol. 30 (1): 59–68. doi:10.1002/1521-4141(200001)30:1<59::AID-IMMU59>3.0.CO;2-1. PMID   10602027. S2CID   40742391.
15. Ravichandran KS, Burakoff SJ (January 1994). "The adapter protein Shc interacts with the interleukin-2 (IL-2) receptor upon IL-2 stimulation". J. Biol. Chem. 269 (3): 1599–602. doi: 10.1016/S0021-9258(17)42066-7 . PMID   8294403.

Further reading

• Ellery JM, Nicholls PJ (2002). "Alternate signalling pathways from the interleukin-2 receptor". Cytokine Growth Factor Rev. 13 (1): 27–40. doi:10.1016/S1359-6101(01)00023-5. PMID   11750878.
• Purvis SF, Georges DL, Williams TM, Lederman MM (1992). "Suppression of interleukin-2 and interleukin-2 receptor expression in Jurkat cells stably expressing the human immunodeficiency virus Tat protein". Cell. Immunol. 144 (1): 32–42. doi:10.1016/0008-8749(92)90223-C. PMID   1394441.
• Torigoe T, Saragovi HU, Reed JC (1992). "Interleukin 2 regulates the activity of the lyn protein-tyrosine kinase in a B-cell line". Proc. Natl. Acad. Sci. U.S.A. 89 (7): 2674–8. Bibcode:1992PNAS...89.2674T. doi: 10.1073/pnas.89.7.2674 . PMC   48724 . PMID   1557373.
• Maslinski W, Remillard B, Tsudo M, Strom TB (1992). "Interleukin-2 (IL-2) induces tyrosine kinase-dependent translocation of active raf-1 from the IL-2 receptor into the cytosol". J. Biol. Chem. 267 (22): 15281–4. doi: 10.1016/S0021-9258(19)49530-6 . PMID   1639773.
• Miyazaki T, Maruyama M, Yamada G, Hatakeyama M, Taniguchi T (1991). "The integrity of the conserved 'WS motif' common to IL-2 and other cytokine receptors is essential for ligand binding and signal transduction". EMBO J. 10 (11): 3191–7. doi:10.1002/j.1460-2075.1991.tb04881.x. PMC   453042 . PMID   1915291.
• Shibuya H, Yoneyama M, Nakamura Y, Harada H, Hatakeyama M, Minamoto S, Kono T, Doi T, White R, Taniguchi T (1990). "The human interleukin-2 receptor beta-chain gene: genomic organization, promoter analysis and chromosomal assignment". Nucleic Acids Res. 18 (13): 3697–703. doi:10.1093/nar/18.13.3697. PMC   331067 . PMID   1973832.
• Hatakeyama M, Kono T, Kobayashi N, Kawahara A, Levin SD, Perlmutter RM, Taniguchi T (1991). "Interaction of the IL-2 receptor with the src-family kinase p56lck: identification of novel intermolecular association". Science. 252 (5012): 1523–8. Bibcode:1991Sci...252.1523H. doi:10.1126/science.2047859. PMID   2047859. S2CID   41503548.
• Mills GB, May C, McGill M, Fung M, Baker M, Sutherland R, Greene WC (1990). "Interleukin 2-induced tyrosine phosphorylation. Interleukin 2 receptor beta is tyrosine phosphorylated". J. Biol. Chem. 265 (6): 3561–7. doi: 10.1016/S0021-9258(19)39806-0 . PMID   2303462.
• Oyaizu N, Chirmule N, Kalyanaraman VS, Hall WW, Pahwa R, Shuster M, Pahwa S (1990). "Human immunodeficiency virus type 1 envelope glycoprotein gp120 produces immune defects in CD4+ T lymphocytes by inhibiting interleukin 2 mRNA". Proc. Natl. Acad. Sci. U.S.A. 87 (6): 2379–83. Bibcode:1990PNAS...87.2379O. doi: 10.1073/pnas.87.6.2379 . PMC   53690 . PMID   2315327.
• Gnarra JR, Otani H, Wang MG, McBride OW, Sharon M, Leonard WJ (1990). "Human interleukin 2 receptor beta-chain gene: chromosomal localization and identification of 5' regulatory sequences". Proc. Natl. Acad. Sci. U.S.A. 87 (9): 3440–4. Bibcode:1990PNAS...87.3440G. doi: 10.1073/pnas.87.9.3440 . PMC   53916 . PMID   2333293.
• Tsudo M, Kitamura F, Miyasaka M (1989). "Characterization of the interleukin 2 receptor beta chain using three distinct monoclonal antibodies". Proc. Natl. Acad. Sci. U.S.A. 86 (6): 1982–6. Bibcode:1989PNAS...86.1982T. doi: 10.1073/pnas.86.6.1982 . PMC   286829 . PMID   2467293.
• Hatakeyama M, Tsudo M, Minamoto S, Kono T, Doi T, Miyata T, Miyasaka M, Taniguchi T (1989). "Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's". Science. 244 (4904): 551–6. Bibcode:1989Sci...244..551H. doi:10.1126/science.2785715. PMID   2785715.
• Kornfeld H, Cruikshank WW, Pyle SW, Berman JS, Center DM (1988). "Lymphocyte activation by HIV-1 envelope glycoprotein". Nature. 335 (6189): 445–8. Bibcode:1988Natur.335..445K. doi:10.1038/335445a0. PMID   2843775. S2CID   4326650.
• Leonard WJ, Donlon TA, Lebo RV, Greene WC (1985). "Localization of the gene encoding the human interleukin-2 receptor on chromosome 10". Science. 228 (4707): 1547–9. Bibcode:1985Sci...228.1547L. doi:10.1126/science.3925551. PMID   3925551.
• Bamborough P, Hedgecock CJ, Richards WG (1994). "The interleukin-2 and interleukin-4 receptors studied by molecular modelling". Structure. 2 (9): 839–51. doi: 10.1016/S0969-2126(94)00085-9 . PMID   7529123.
• Minami Y, Nakagawa Y, Kawahara A, Miyazaki T, Sada K, Yamamura H, Taniguchi T (1995). "Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor: possible link with the c-myc induction pathway". Immunity. 2 (1): 89–100. doi: 10.1016/1074-7613(95)90081-0 . PMID   7600304.
• Giri JG, Kumaki S, Ahdieh M, Friend DJ, Loomis A, Shanebeck K, DuBose R, Cosman D, Park LS, Anderson DM (1995). "Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor". EMBO J. 14 (15): 3654–63. doi:10.1002/j.1460-2075.1995.tb00035.x. PMC   394440 . PMID   7641685.
• Kirken RA, Rui H, Evans GA, Farrar WL (1993). "Characterization of an interleukin-2 (IL-2)-induced tyrosine phosphorylated 116-kDa protein associated with the IL-2 receptor beta-subunit". J. Biol. Chem. 268 (30): 22765–70. doi: 10.1016/S0021-9258(18)41592-X . PMID   7693677.
• Puri RK, Leland P, Aggarwal BB (1995). "Constitutive expression of human immunodeficiency virus type 1 tat gene inhibits interleukin 2 and interleukin 2 receptor expression in a human CD4+ T lymphoid (H9) cell line". AIDS Res. Hum. Retroviruses. 11 (1): 31–40. doi:10.1089/aid.1995.11.31. PMID   7734194.
• Miyazaki T, Liu ZJ, Kawahara A, Minami Y, Yamada K, Tsujimoto Y, Barsoumian EL, Permutter RM, Taniguchi T (1995). "Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation". Cell. 81 (2): 223–31. doi: 10.1016/0092-8674(95)90332-1 . PMID   7736574.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.