CD180

CD180
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3B2D
Identifiers
Aliases	CD180 , LY64, Ly78, RP105, CD180 molecule
External IDs	OMIM: 602226; MGI: 1194924; HomoloGene: 4077; GeneCards: CD180; OMA:CD180 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q12.3 Start 67,179,613 bp [1] End 67,196,799 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13|13 D1 Start 102,830,066 bp [2] End 102,876,137 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell lymph node white blood cell monocyte granulocyte spleen appendix bone marrow cells blood superficial temporal artery Top expressed in mesenteric lymph nodes zygote granulocyte secondary oocyte spleen primary oocyte right ventricle tibiofemoral joint blood thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane extracellular space extracellular matrix Biological process positive regulation of lipopolysaccharide-mediated signaling pathway innate immune response cellular response to lipopolysaccharide B cell proliferation involved in immune response immune system process toll-like receptor signaling pathway inflammatory response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4064 17079 Ensembl ENSG00000134061 ENSMUSG00000021624 UniProt Q99467 Q62192 RefSeq (mRNA) NM_005582 NM_008533 NM_001360519 RefSeq (protein) NP_005573 NP_032559 NP_001347448 Location (UCSC) Chr 5: 67.18 – 67.2 Mb Chr 13: 102.83 – 102.88 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CD180 antigen is a protein that in humans is encoded by the CD180 gene. ^{[5] [6] [7] [8]}

CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. It is also known by the archaic terms Bgp-95 and RP105, for the founding designations following discovery in humans (1988) and mice (1994), respectively. CD180 is expressed on antigen presenting cells including B cells and dendritic cells. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, CD180/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). CD180/MD-1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. ^[7]

Recently, CD180 has been demonstrated to be involved in the survival and prognosis of B-cell chronic lymphocytic leukemia. ^{[9] [10]}

References

1. GRCh38: Ensembl release 89: ENSG00000134061 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021624 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Miura Y, Shimazu R, Miyake K, Akashi S, Ogata H, Yamashita Y, et al. (Nov 1998). "RP105 is associated with MD-1 and transmits an activation signal in human B cells". Blood. 92 (8): 2815–2822. doi:10.1182/blood.V92.8.2815. PMID   9763566.
6. Miura Y, Miyake K, Yamashita Y, Shimazu R, Copeland NG, Gilbert DJ, et al. (Mar 1997). "Molecular cloning of a human RP105 homologue and chromosomal localization of the mouse and human RP105 genes (Ly64 and LY64)". Genomics. 38 (3): 299–304. doi:10.1006/geno.1996.0632. PMID   8975706.
7. "Entrez Gene: CD180 CD180 molecule".
8. [4]
9. Porakishvili N, Memon A, Vispute K, Kulikova N, Clark EA, Rai KR, et al. (May 2011). "CD180 functions in activation, survival and cycling of B chronic lymphocytic leukaemia cells". British Journal of Haematology. 153 (4): 486–498. doi: 10.1111/j.1365-2141.2011.08605.x . ISSN   0007-1048. PMID   21443749. S2CID   13360804.
10. Gordiienko I, Shlapatska L, Kholodniuk V, Sklyarenko L, Gluzman DF, Clark EA, et al. (2017-10-05). "The interplay of CD150 and CD180 receptor pathways contribute to the pathobiology of chronic lymphocytic leukemia B cells by selective inhibition of Akt and MAPK signaling". PLOS ONE. 12 (10): e0185940. Bibcode:2017PLoSO..1285940G. doi: 10.1371/journal.pone.0185940 . ISSN   1932-6203. PMC   5628907 . PMID   28982149.

Further reading

• Honda Y, Yamagiwa S, Matsuda Y, et al. (2007). "Altered expression of TLR homolog RP105 on monocytes hypersensitive to LPS in patients with primary biliary cirrhosis". J. Hepatol. 47 (3): 404–411. doi:10.1016/j.jhep.2007.03.012. PMID   17448566.
• Divanovic S, Trompette A, Atabani SF, et al. (2005). "Negative Regulation of TLR4 Signaling by RP105". Nat. Immunol. 6 (6): 571–578. doi:10.1038/ni1198. PMC   2144914 . PMID   15852007.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–1718. doi:10.1101/gr.2435604. PMC   515316 . PMID   15342556.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–2824. doi:10.1110/ps.04682504. PMC   2286551 . PMID   15340161.
• Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–197. doi:10.1038/nm822. PMID   12539042. S2CID   26145639.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Miyake K, Shimazu R, Kondo J, et al. (1998). "Mouse MD-1, a molecule that is physically associated with RP105 and positively regulates its expression". J. Immunol. 161 (3): 1348–1353. doi:10.4049/jimmunol.161.3.1348. PMID   9686597.

External links

• Human CD180 genome location and CD180 gene details page in the UCSC Genome Browser .
• Overview of all the structural information available in the PDB for UniProt : Q99467 (Human CD180 antigen) at the PDBe-KB .
• Overview of all the structural information available in the PDB for UniProt : Q62192 (Mouse CD180 antigen) at the PDBe-KB .