CD180

Last updated
CD180
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CD180 , LY64, Ly78, RP105, CD180 molecule
External IDs OMIM: 602226 MGI: 1194924 HomoloGene: 4077 GeneCards: CD180
Orthologs
SpeciesHumanMouse
Entrez

4064

17079

Ensembl

ENSG00000134061

ENSMUSG00000021624

UniProt

Q99467

Q62192

RefSeq (mRNA)

NM_005582

NM_008533
NM_001360519

RefSeq (protein)

NP_005573

NP_032559
NP_001347448

Location (UCSC) Chr 5: 67.18 – 67.2 Mb Chr 13: 102.83 – 102.88 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CD180 antigen is a protein that in humans is encoded by the CD180 gene. [5] [6] [7] [8]

Contents

CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. It is also known by the archaic terms Bgp-95 and RP105, for the founding designations following discovery in humans (1988) and mice (1994), respectively. CD180 is expressed on antigen presenting cells including B cells and dendritic cells. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, CD180/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). CD180/MD-1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [7]

Recently, CD180 has been demonstrated to be involved in the survival and prognosis of B-cell chronic lymphocytic leukemia. [9] [10]

Related Research Articles

<span class="mw-page-title-main">Integrin alpha X</span> Mammalian protein found in Homo sapiens

CD11c, also known as Integrin, alpha X (ITGAX), is a gene that encodes for CD11c.

<span class="mw-page-title-main">Toll-like receptor 4</span> Protein-coding gene in the species Homo sapiens

Toll-like receptor 4 is a protein that in humans is encoded by the TLR4 gene. TLR4 is a transmembrane protein, member of the toll-like receptor family, which belongs to the pattern recognition receptor (PRR) family. Its activation leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system.

<span class="mw-page-title-main">Lymphocyte antigen 96</span> Protein-coding gene in the species Homo sapiens

Lymphocyte antigen 96, also known as "Myeloid Differentiation factor 2 (MD-2)," is a protein that in humans is encoded by the LY96 gene.

<span class="mw-page-title-main">CD244</span> Protein found in humans

CD244 also known as 2B4 or SLAMF4 is a protein that in humans is encoded by the CD244 gene.

<span class="mw-page-title-main">Basal cell adhesion molecule</span> Protein-coding gene in the species Homo sapiens

Basal cell adhesion molecule, also known as Lutheran antigen, is a plasma membrane glycoprotein that in humans is encoded by the BCAM gene. BCAM has also recently been designated CD239.

<span class="mw-page-title-main">SLAMF6</span> Protein-coding gene in humans

SLAM family member 6 is a protein that in humans is encoded by the SLAMF6 gene.

<span class="mw-page-title-main">CEACAM3</span> Mammalian protein found in Homo sapiens

Carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3) also known as CD66d, is a member of the carcinoembryonic antigen (CEA) gene family..

<span class="mw-page-title-main">Interleukin-21 receptor</span> Protein-coding gene in the species Homo sapiens

Interleukin 21 receptor is a type I cytokine receptor. IL21R is its human gene.

<span class="mw-page-title-main">BST1</span> Protein-coding gene in the species Homo sapiens

Bst1 is an enzyme that in humans is encoded by the BST1 gene. CD157 is a paralog of CD38, both of which are located on chromosome 4 (4p15) in humans.

<span class="mw-page-title-main">FCRL5</span> Protein-coding gene in the species Homo sapiens

Fc receptor-like protein 5 is a protein that in humans is encoded by the FCRL5 gene. FCRL5 has also been designated as CD307.

<span class="mw-page-title-main">SIRPB1</span> Protein-coding gene in the species Homo sapiens

Signal-regulatory protein beta-1 is a protein that in humans is encoded by the SIRPB1 gene. SIRPB1 has also recently been designated CD172B.

<span class="mw-page-title-main">CD320</span> Human gene

CD320 is a human gene.

<span class="mw-page-title-main">SIRPG</span> Protein-coding gene in the species Homo sapiens

Signal-regulatory protein gamma is a protein that in humans is encoded by the SIRPG gene. SIRPG has also recently been designated CD172G.

<span class="mw-page-title-main">SIGIRR</span> Protein-coding gene in the species Homo sapiens

Single Ig IL-1-related receptor (SIGIRR), also called Toll/Interleukin-1 receptor 8 (TIR8) or Interleukin-1 receptor 8 (IL-1R8), is transmembrane protein encoded by gene SIGIRR, which modulate inflammation, immune response, and tumorigenesis of colonic epithelial cells.

<span class="mw-page-title-main">IGSF2</span> Human gene

Immunoglobulin superfamily, member 2 (IGSF2) also known as CD101, is a human gene.

<span class="mw-page-title-main">CD300A</span> Human gene

CD300A is a human gene.

<span class="mw-page-title-main">TICAM2</span> Protein-coding gene in the species Homo sapiens

TIR domain-containing adapter molecule 2 is a protein that in humans is encoded by the TICAM2 gene.

<span class="mw-page-title-main">SPECC1</span> Protein-coding gene in the species Homo sapiens

Cytospin-B is a protein that, in humans, is encoded by the CYTSB gene.

<span class="mw-page-title-main">RAB7B</span> Protein-coding gene in the species Homo sapiens

Ras-related protein Rab-7b is a protein that in humans is encoded by the RAB7B gene.

<span class="mw-page-title-main">Protein THEMIS</span> Protein-coding gene in the species Homo sapiens

Protein THEMIS is a protein encoded by the eponymous THEMIS gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000134061 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021624 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Miura Y, Shimazu R, Miyake K, Akashi S, Ogata H, Yamashita Y, Narisawa Y, Kimoto M (Nov 1998). "RP105 is associated with MD-1 and transmits an activation signal in human B cells". Blood. 92 (8): 2815–22. doi:10.1182/blood.V92.8.2815. PMID   9763566.
  6. ↑ Miura Y, Miyake K, Yamashita Y, Shimazu R, Copeland NG, Gilbert DJ, Jenkins NA, Inazawa J, Abe T, Kimoto M (Mar 1997). "Molecular cloning of a human RP105 homologue and chromosomal localization of the mouse and human RP105 genes (Ly64 and LY64)". Genomics. 38 (3): 299–304. doi:10.1006/geno.1996.0632. PMID   8975706.
  7. 1 2 "Entrez Gene: CD180 CD180 molecule".
  8. ↑ [4]
  9. ↑ Porakishvili N, Memon A, Vispute K, Kulikova N, Clark EA, Rai KR, Nathwani A, Damle RN, Chiorazzi N, Lydyard PM (May 2011). "CD180 functions in activation, survival and cycling of B chronic lymphocytic leukaemia cells". British Journal of Haematology. 153 (4): 486–498. doi: 10.1111/j.1365-2141.2011.08605.x . ISSN   0007-1048. PMID   21443749. S2CID   13360804.
  10. ↑ Gordiienko I, Shlapatska L, Kholodniuk V, Sklyarenko L, Gluzman DF, Clark EA, Sidorenko SP (2017-10-05). "The interplay of CD150 and CD180 receptor pathways contribute to the pathobiology of chronic lymphocytic leukemia B cells by selective inhibition of Akt and MAPK signaling". PLOS ONE. 12 (10): e0185940. Bibcode:2017PLoSO..1285940G. doi: 10.1371/journal.pone.0185940 . ISSN   1932-6203. PMC   5628907 . PMID   28982149.

Further reading

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.