CD164

CD164
Identifiers
Aliases	CD164 , MGC-24, MUC-24, endolyn, DFNA66, CD164 molecule, MGC-24v
External IDs	OMIM: 603356 MGI: 1859568 HomoloGene: 38129 GeneCards: CD164
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q21 Start 109,366,514 bp [1] End 109,382,467 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10 B2|10 22.46 cM Start 41,395,410 bp [2] End 41,407,044 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell kidney tubule secondary oocyte lactiferous duct rectum glomerulus corpus epididymis metanephric glomerulus caput epididymis parotid gland Top expressed in parotid gland submandibular gland iris retinal pigment epithelium lacrimal gland cornea islet of Langerhans corneal stroma calvaria conjunctival fornix More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component integral component of membrane extracellular region lysosomal membrane endosome plasma membrane lysosome integral component of plasma membrane endosome membrane membrane cytoplasmic vesicle Biological process multicellular organism development negative regulation of cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules cell adhesion muscle organ development immune response signal transduction negative regulation of cell population proliferation hemopoiesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8763 53599 Ensembl ENSG00000135535 ENSMUSG00000019818 UniProt Q04900 Q9R0L9 RefSeq (mRNA) NM_006016 NM_001142401 NM_001142402 NM_001142403 NM_001142404 NM_001346500 NM_016898 RefSeq (protein) NP_001135873 NP_001135874 NP_001135875 NP_001135876 NP_001333429 NP_006007 NP_058594 Location (UCSC) Chr 6: 109.37 – 109.38 Mb Chr 10: 41.4 – 41.41 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sialomucin core protein 24 also known as endolyn or CD164 (cluster of differentiation 164) is a protein that in humans is encoded by the CD164 gene. ^{[5] [6]} CD164 functions as a cell adhesion molecule.

Sialomucins are a heterogeneous group of secreted or membrane-associated mucins that appear to play two key but opposing roles in vivo: first as cytoprotective or antiadhesive agents, and second as adhesion receptors. CD164 is a type I integral transmembrane sialomucin that functions as an adhesion receptor. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000135535 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019818 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Watt SM, Bühring HJ, Rappold I, Chan JY, Lee-Prudhoe J, Jones T, Zannettino AC, Simmons PJ, Doyonnas R, Sheer D, Butler LH (August 1998). "CD164, a novel sialomucin on CD34(+) and erythroid subsets, is located on human chromosome 6q21". Blood. 92 (3): 849–66. doi:10.1182/blood.V92.3.849. PMID   9680353.
6. Zannettino AC, Bühring HJ, Niutta S, Watt SM, Benton MA, Simmons PJ (October 1998). "The sialomucin CD164 (MGC-24v) is an adhesive glycoprotein expressed by human hematopoietic progenitors and bone marrow stromal cells that serves as a potent negative regulator of hematopoiesis". Blood. 92 (8): 2613–28. doi:10.1182/blood.V92.8.2613. PMID   9763543.

Further reading

• Zannettino AC (2001). "CD164". J. Biol. Regul. Homeost. Agents. 15 (4): 394–6. PMID   11862985.
• Masuzawa Y, Miyauchi T, Hamanoue M, et al. (1992). "A novel core protein as well as polymorphic epithelial mucin carry peanut agglutinin binding sites in human gastric carcinoma cells: sequence analysis and examination of gene expression". J. Biochem. 112 (5): 609–15. doi:10.1093/oxfordjournals.jbchem.a123948. PMID   1478919.
• Zhou GQ, Zhang Y, Ferguson DJ, et al. (2006). "The Drosophila ortholog of the endolysosomal membrane protein, endolyn, regulates cell proliferation". J. Cell. Biochem. 99 (5): 1380–96. doi:10.1002/jcb.20965. PMID   16924678. S2CID   6995864.
• Chan JY, Lee-Prudhoe JE, Jorgensen B, et al. (2001). "Relationship between novel isoforms, functionally important domains, and subcellular distribution of CD164/endolyn". J. Biol. Chem. 276 (3): 2139–52. doi: 10.1074/jbc.M007965200 . PMID   11027692.
• Ganesh SK, Zakai NA, van Rooij FJ, et al. (2009). "Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium". Nat. Genet. 41 (11): 1191–8. doi:10.1038/ng.466. PMC   2778265 . PMID   19862010.
• Barbe L, Lundberg E, Oksvold P, et al. (2008). "Toward a confocal subcellular atlas of the human proteome". Mol. Cell. Proteomics. 7 (3): 499–508. doi: 10.1074/mcp.M700325-MCP200 . PMID   18029348.
• Kurosawa N, Kanemitsu Y, Matsui T, et al. (1999). "Genomic analysis of a murine cell-surface sialomucin, MGC-24/CD164". Eur. J. Biochem. 265 (1): 466–72. doi:10.1046/j.1432-1327.1999.00777.x. PMID   10491205.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.
• Doyonnas R, Yi-Hsin Chan J, Butler LH, et al. (2000). "CD164 monoclonal antibodies that block hemopoietic progenitor cell adhesion and proliferation interact with the first mucin domain of the CD164 receptor". J. Immunol. 165 (2): 840–51. doi: 10.4049/jimmunol.165.2.840 . PMID   10878358.
• Gudbjartsson DF, Walters GB, Thorleifsson G, et al. (2008). "Many sequence variants affecting diversity of adult human height". Nat. Genet. 40 (5): 609–15. doi:10.1038/ng.122. PMID   18391951. S2CID   3005450.
• Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Oh JH, Yang JO, Hahn Y, et al. (2005). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID   16341674. S2CID   69278.
• Havens AM, Jung Y, Sun YX, et al. (2006). "The role of sialomucin CD164 (MGC-24v or endolyn) in prostate cancer metastasis". BMC Cancer. 6: 195. doi:10.1186/1471-2407-6-195. PMC   1557671 . PMID   16859559.
• Forde S, Tye BJ, Newey SE, et al. (2007). "Endolyn (CD164) modulates the CXCL12-mediated migration of umbilical cord blood CD133+ cells". Blood. 109 (5): 1825–33. doi: 10.1182/blood-2006-05-023028 . PMID   17077324. S2CID   14472393.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Hennersdorf F, Florian S, Jakob A, et al. (2005). "Identification of CD13, CD107a, and CD164 as novel basophil-activation markers and dissection of two response patterns in time kinetics of IgE-dependent upregulation". Cell Res. 15 (5): 325–35. doi: 10.1038/sj.cr.7290301 . PMID   15916720.

External links

• CD164+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human CD164 genome location and CD164 gene details page in the UCSC Genome Browser .