CDH12

CDH12
Identifiers
Aliases	CDH12 , CDHB, cadherin 12
External IDs	OMIM: 600562 MGI: 109503 HomoloGene: 37873 GeneCards: CDH12
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5p14.3 Start 21,750,673 bp [1] End 22,853,622 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15 A2|15 8.25 cM Start 20,449,265 bp [2] End 21,589,533 bp [2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • metal ion binding • cytoskeletal protein binding • protein homodimerization activity • cadherin binding Cellular component • integral component of membrane • plasma membrane • membrane • cell surface • catenin complex Biological process • cell adhesion • adherens junction organization • homophilic cell adhesion via plasma membrane adhesion molecules • cell-cell junction assembly • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules • cell-cell adhesion mediated by cadherin • cell-cell adhesion • cell morphogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1010	215654
Ensembl	ENSG00000154162	ENSMUSG00000040452
UniProt	P55289	Q5RJH3
RefSeq (mRNA)	NM_004061 NM_001317227 NM_001317228	NM_001008420
RefSeq (protein)	NP_001304156 NP_001304157 NP_004052 NP_001351033 NP_001351034 NP_001351035 NP_001351036 NP_001351037 NP_001351038	NP_001008420
Location (UCSC)	Chr 5: 21.75 – 22.85 Mb	Chr 15: 20.45 – 21.59 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Cadherin-12 is a protein that in humans is encoded by the CDH12 gene. ^{[5] [6]}

This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of an HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000154162 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040452 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Selig S, Bruno S, Scharf JM, Wang CH, Vitale E, Gilliam TC, Kunkel LM (Jun 1995). "Expressed cadherin pseudogenes are localized to the critical region of the spinal muscular atrophy gene". Proc Natl Acad Sci U S A. 92 (9): 3702–6. doi: 10.1073/pnas.92.9.3702 . PMC   42029 . PMID   7731968.
6. "Entrez Gene: CDH12 cadherin 12, type 2 (N-cadherin 2)".

Further reading

• Jean Weissenbach; Gyapay G; Dib C; et al. (1992). "A second-generation linkage map of the human genome". Nature. 359 (6398): 794–801. doi:10.1038/359794a0. PMID   1436057. S2CID   4331117.
• Suzuki S, Sano K, Tanihara H (1991). "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue". Cell Regul. 2 (4): 261–70. doi:10.1091/mbc.2.4.261. PMC   361775 . PMID   2059658.
• Gyapay G, Morissette J, Vignal A, et al. (1994). "The 1993-94 Généthon human genetic linkage map". Nat. Genet. 7 (2 Spec No): 246–339. doi:10.1038/ng0694supp-246. PMID   7545953. S2CID   24662426.
• Tanihara H, Sano K, Heimark RL, et al. (1995). "Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin". Cell Adhes. Commun. 2 (1): 15–26. doi:10.3109/15419069409014199. PMID   7982033.
• Selig S, Lidov HG, Bruno SA, et al. (1997). "Molecular characterization of Br-cadherin, a developmentally regulated, brain-specific cadherin". Proc. Natl. Acad. Sci. U.S.A. 94 (6): 2398–403. doi: 10.1073/pnas.94.6.2398 . PMC   20099 . PMID   9122206.
• Kremmidiotis G, Baker E, Crawford J, et al. (1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics. 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID   9615235.
• Chalmers IJ, Höfler H, Atkinson MJ (1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma". Genomics. 57 (1): 160–3. doi:10.1006/geno.1998.5717. PMID   10191097.
• Shimoyama Y, Tsujimoto G, Kitajima M, Natori M (2001). "Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins". Biochem. J. 349 (Pt 1): 159–67. doi:10.1042/0264-6021:3490159. PMC   1221133 . PMID   10861224.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.

External links

• CDH12 human gene location in the UCSC Genome Browser .
• CDH12 human gene details in the UCSC Genome Browser .