CADM3

CADM3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Z9M
Identifiers
Aliases	CADM3 , BIgR, IGSF4B, NECL1, Necl-1, TSLL1, synCAM3, cell adhesion molecule 3, CMT2FF
External IDs	OMIM: 609743 MGI: 2137858 HomoloGene: 10919 GeneCards: CADM3
Gene location (Human)
Chr.	Chromosome 1 (human)
End	159,203,313 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	173,195,261 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; tibial nerve; ; nucleus accumbens; ; Brodmann area 9; ; prefrontal cortex; ; sural nerve; ; amygdala; ; Brodmann area 10; ; caudate nucleus; ; ganglionic eminence;
	Top expressed in
	cerebellar cortex; ; superior frontal gyrus; ; piriform cortex; ; cerebellar vermis; ; motor neuron; ; sciatic nerve; ; primary motor cortex; ; ventromedial nucleus; ; temporal lobe; ; dorsomedial hypothalamic nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	signaling receptor binding ; protein homodimerization activity ; cell adhesion molecule binding ;
Cellular component	integral component of membrane ; cell junction ; plasma membrane ; integral component of plasma membrane ; membrane ; cell-cell junction ; parallel fiber to Purkinje cell synapse ; integral component of presynaptic membrane ;
Biological process	protein localization ; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ; cell adhesion ; cell recognition ; adherens junction organization ; homophilic cell adhesion via plasma membrane adhesion molecules ;
	Sources:Amigo / QuickGO
Orthologs
	57863
	94332
	ENSG00000162706
	ENSMUSG00000005338
	Q8N126
	Q99N28
	NM_021189 ; NM_001127173 ; NM_001346510
	NM_053199
	NP_001120645 ; NP_001333439 ; NP_067012
	NP_444429
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 29, 2023

Cell adhesion molecule 3 is a protein that in humans is encoded by the CADM3 gene.^[5]^[6]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000162706 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005338 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Fukuhara H, Kuramochi M, Nobukuni T, Fukami T, Saino M, Maruyama T, Nomura S, Sekiya T, Murakami Y (Sep 2001). "Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins". Oncogene. 20 (38): 5401–7. doi:10.1038/sj.onc.1204696. PMID 11536053.
1 2 "Entrez Gene: CADM3 cell adhesion molecule 3".

External links

Human CADM3 genome location and CADM3 gene details page in the UCSC Genome Browser .

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Shingai T, Ikeda W, Kakunaga S, et al. (2003). "Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells". J. Biol. Chem. 278 (37): 35421–7. doi: 10.1074/jbc.M305387200 . PMID 12826663.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697 . PMID 12975309.
Fukami T, Satoh H, Williams YN, et al. (2004). "Isolation of the mouse Tsll1 and Tsll2 genes, orthologues of the human TSLC1-like genes 1 and 2 (TSLL1 and TSLL2)". Gene. 323: 11–8. doi:10.1016/j.gene.2003.09.018. PMID 14659875.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551 . PMID 15340161.
Kakunaga S, Ikeda W, Itoh S, et al. (2005). "Nectin-like molecule-1/TSLL1/SynCAM3: a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule localizing at non-junctional contact sites of presynaptic nerve terminals, axons and glia cell processes". J. Cell Sci. 118 (Pt 6): 1267–77. doi:10.1242/jcs.01656. PMID 15741237.
Zhou Y, Du G, Hu X, et al. (2005). "Nectin-like molecule 1 is a protein 4.1N associated protein and recruits protein 4.1N from cytoplasm to the plasma membrane". Biochim. Biophys. Acta. 1669 (2): 142–54. doi:10.1016/j.bbamem.2005.01.013. PMID 15893517.
Dong X, Xu F, Gong Y, et al. (2006). "Crystal structure of the V domain of human Nectin-like molecule-1/Syncam3/Tsll1/Igsf4b, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule". J. Biol. Chem. 281 (15): 10610–7. doi: 10.1074/jbc.M513459200 . PMID 16467305.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID 16710414.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000162706 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005338 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11536053-5] Fukuhara H, Kuramochi M, Nobukuni T, Fukami T, Saino M, Maruyama T, Nomura S, Sekiya T, Murakami Y (Sep 2001). "Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins". Oncogene. 20 (38): 5401–7. doi:10.1038/sj.onc.1204696. PMID 11536053.

[entrez-6] 1 2 "Entrez Gene: CADM3 cell adhesion molecule 3".

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CADM3

Contents

Related Research Articles

References

External links

Further reading