CDH15

CDH15
Identifiers
Aliases	CDH15 , CDH14, CDH3, CDHM, MCAD, MRD3, cadherin 15
External IDs	OMIM: 114019 MGI: 106672 HomoloGene: 3622 GeneCards: CDH15
Gene location (Human)
Chr.	Chromosome 16 (human)
End	89,195,492 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	123,594,136 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; gastrocnemius muscle; ; tibialis anterior muscle; ; deltoid muscle; ; tibia; ; cerebellar vermis; ; sural nerve; ; periodontal fiber; ; canal of the cervix; ; face;
	Top expressed in
	temporal muscle; ; triceps brachii muscle; ; vastus lateralis muscle; ; body of femur; ; ankle; ; internal carotid artery; ; sternocleidomastoid muscle; ; cerebellar cortex; ; skeletal muscle tissue; ; soleus muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding ; protein binding ; metal ion binding ; cytoskeletal protein binding ; protein homodimerization activity ; cadherin binding ;
Cellular component	caveola ; integral component of membrane ; neuromuscular junction ; plasma membrane ; extracellular exosome ; membrane ; Golgi apparatus ; cytosol ; cell surface ; catenin complex ;
Biological process	cell adhesion ; adherens junction organization ; positive regulation of muscle cell differentiation ; homophilic cell adhesion via plasma membrane adhesion molecules ; cell morphogenesis ; cell-cell junction assembly ; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules ; cell-cell adhesion mediated by cadherin ; cell-cell adhesion ;
	Sources:Amigo / QuickGO
Orthologs
	1013
	12555
	ENSG00000129910
	ENSMUSG00000031962
	P55291
	P33146
	NM_004933
	NM_007662
	NP_004924
	NP_031688
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 29, 2022

Cadherin-15 is a protein that in humans is encoded by the CDH15 gene.^[5]^[6]

Function

This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation.^[6]

Interactions

CDH15 has been shown to interact with ARVCF.^[7]

Related Research Articles

T-cadherin, also known as cadherin 13, H-cadherin (heart), and CDH13, is a unique member of the cadherin superfamily of proteins because it lacks the transmembrane and cytoplasmic domains common to all other cadherins and is instead anchored to the cell's plasma membrane by the GPI anchor.

Cadherin-2 also known as Neural cadherin (N-cadherin), is a protein that in humans is encoded by the CDH2 gene. CDH2 has also been designated as CD325 . Cadherin-2 is a transmembrane protein expressed in multiple tissues and functions to mediate cell–cell adhesion. In cardiac muscle, Cadherin-2 is an integral component in adherens junctions residing at intercalated discs, which function to mechanically and electrically couple adjacent cardiomyocytes. Alterations in expression and integrity of Cadherin-2 has been observed in various forms of disease, including human dilated cardiomyopathy. Variants in CDH2 have also been identified to cause a syndromic neurodevelopmental disorder.

Cadherin 5, type 2 or VE-cadherin also known as CD144, is a type of cadherin. It is encoded by the human gene CDH5.

Cadherin EGF LAG seven-pass G-type receptor 3 is a protein that in humans is encoded by the CELSR3 gene.

Cadherin-3, also known as P-Cadherin, is a protein that in humans is encoded by the CDH3 gene.

Cadherin-11 is a protein that in humans is encoded by the CDH11 gene.

Cadherin-4 is a protein that in humans is encoded by the CDH4 gene.

Cadherin-6 is a protein that in humans is encoded by the CDH6 gene.

Armadillo repeat protein deleted in velo-cardio-facial syndrome is a protein that in humans is encoded by the ARVCF gene.

Cadherin-16 is a protein that in humans is encoded by the CDH16 gene.

Cadherin-17 is a protein that in humans is encoded by the CDH17 gene.

Cadherin-12 is a protein that in humans is encoded by the CDH12 gene.

Protocadherin beta-14 is a protein that in humans is encoded by the PCDHB14 gene.

Cadherin-8 is a protein that in humans is encoded by the CDH8 gene.

Protocadherin beta-4 is a protein that in humans is encoded by the PCDHB4 gene.

αE-catenin, also known as Catenin alpha-1 is a protein that in humans is encoded by the CTNNA1 gene. αE-catenin is highly expressed in cardiac muscle and localizes to adherens junctions at intercalated disc structures where it functions to mediate the anchorage of actin filaments to the sarcolemma. αE-catenin also plays a role in tumor metastasis and skin cell function.

Protocadherin beta-15 is a protein that in humans is encoded by the PCDHB15 gene.

Protocadherin beta-3 is a protein that in humans is encoded by the PCDHB3 gene.

Cadherin 10 is a protein that in humans is encoded by the CDH10 gene.

Cadherin 9 is a protein that in humans is encoded by the CDH9 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000129910 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031962 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kaupmann K, Becker-Follmann J, Scherer G, Jockusch H, Starzinski-Powitz A (December 1992). "The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species". Genomics. 14 (2): 488–90. doi:10.1016/S0888-7543(05)80247-2. PMID 1427864.
1 2 "Entrez Gene: CDH15 cadherin 15, M-cadherin (myotubule)".
↑ Kaufmann U, Zuppinger C, Waibler Z, Rudiger M, Urbich C, Martin B, Jockusch BM, Eppenberger H, Starzinski-Powitz A (November 2000). "The armadillo repeat region targets ARVCF to cadherin-based cellular junctions". J. Cell Sci. 113 (22): 4121–35. doi:10.1242/jcs.113.22.4121. PMID 11058098.

External links

CDH15 human gene location in the UCSC Genome Browser .
CDH15 human gene details in the UCSC Genome Browser .
Human CDH3 genome location and CDH3 gene details page in the UCSC Genome Browser .

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000129910 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031962 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1427864-5] Kaupmann K, Becker-Follmann J, Scherer G, Jockusch H, Starzinski-Powitz A (December 1992). "The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species". Genomics. 14 (2): 488–90. doi:10.1016/S0888-7543(05)80247-2. PMID 1427864.

[entrez-6] 1 2 "Entrez Gene: CDH15 cadherin 15, M-cadherin (myotubule)".

[pmid11058098-7] Kaufmann U, Zuppinger C, Waibler Z, Rudiger M, Urbich C, Martin B, Jockusch BM, Eppenberger H, Starzinski-Powitz A (November 2000). "The armadillo repeat region targets ARVCF to cadherin-based cellular junctions". J. Cell Sci. 113 (22): 4121–35. doi:10.1242/jcs.113.22.4121. PMID 11058098.

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