CDH15 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | CDH15 , CDH14, CDH3, CDHM, MCAD, MRD3, cadherin 15 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 114019 MGI: 106672 HomoloGene: 3622 GeneCards: CDH15 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Cadherin-15 is a protein that in humans is encoded by the CDH15 gene. [5] [6]
This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation. [6]
T-cadherin, also known as cadherin 13, H-cadherin (heart), and CDH13, is a unique member of the cadherin superfamily of proteins because it lacks the transmembrane and cytoplasmic domains common to all other cadherins and is instead anchored to the cell's plasma membrane by the GPI anchor.
Cadherin-2 also known as Neural cadherin (N-cadherin), is a protein that in humans is encoded by the CDH2 gene. CDH2 has also been designated as CD325 . Cadherin-2 is a transmembrane protein expressed in multiple tissues and functions to mediate cell–cell adhesion. In cardiac muscle, Cadherin-2 is an integral component in adherens junctions residing at intercalated discs, which function to mechanically and electrically couple adjacent cardiomyocytes. Alterations in expression and integrity of Cadherin-2 has been observed in various forms of disease, including human dilated cardiomyopathy. Variants in CDH2 have also been identified to cause a syndromic neurodevelopmental disorder.
Cadherin 5, type 2 or VE-cadherin also known as CD144, is a type of cadherin. It is encoded by the human gene CDH5.
Cadherin EGF LAG seven-pass G-type receptor 3 is a protein that in humans is encoded by the CELSR3 gene.
Cadherin-3, also known as P-Cadherin, is a protein that in humans is encoded by the CDH3 gene.
Cadherin-11 is a protein that in humans is encoded by the CDH11 gene.
Cadherin-4 is a protein that in humans is encoded by the CDH4 gene.
Cadherin-6 is a protein that in humans is encoded by the CDH6 gene.
Armadillo repeat protein deleted in velo-cardio-facial syndrome is a protein that in humans is encoded by the ARVCF gene.
Cadherin-16 is a protein that in humans is encoded by the CDH16 gene.
Cadherin-17 is a protein that in humans is encoded by the CDH17 gene.
Cadherin-12 is a protein that in humans is encoded by the CDH12 gene.
Protocadherin beta-14 is a protein that in humans is encoded by the PCDHB14 gene.
Cadherin-8 is a protein that in humans is encoded by the CDH8 gene.
Protocadherin beta-4 is a protein that in humans is encoded by the PCDHB4 gene.
αE-catenin, also known as Catenin alpha-1 is a protein that in humans is encoded by the CTNNA1 gene. αE-catenin is highly expressed in cardiac muscle and localizes to adherens junctions at intercalated disc structures where it functions to mediate the anchorage of actin filaments to the sarcolemma. αE-catenin also plays a role in tumor metastasis and skin cell function.
Protocadherin beta-15 is a protein that in humans is encoded by the PCDHB15 gene.
Protocadherin beta-3 is a protein that in humans is encoded by the PCDHB3 gene.
Cadherin 10 is a protein that in humans is encoded by the CDH10 gene.
Cadherin 9 is a protein that in humans is encoded by the CDH9 gene.