CDH15

CDH15
Identifiers
Aliases	CDH15 , CDH14, CDH3, CDHM, MCAD, MRD3, cadherin 15
External IDs	OMIM: 114019; MGI: 106672; HomoloGene: 3622; GeneCards: CDH15; OMA:CDH15 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	89,195,492 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	123,594,136 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; right hemisphere of cerebellum; ; gastrocnemius muscle; ; muscle of thigh; ; Skeletal muscle tissue of rectus abdominis; ; glutes; ; tibialis anterior muscle; ; deltoid muscle; ; paraflocculus of cerebellum; ; tibia;
	Top expressed in
	myotome; ; muscle of thigh; ; lumbar spinal ganglion; ; temporal muscle; ; triceps brachii muscle; ; vastus lateralis muscle; ; body of femur; ; ankle; ; internal carotid artery; ; sternocleidomastoid muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding ; protein binding ; metal ion binding ; cytoskeletal protein binding ; protein homodimerization activity ; cadherin binding ;
Cellular component	caveola ; integral component of membrane ; neuromuscular junction ; plasma membrane ; extracellular exosome ; membrane ; Golgi apparatus ; cytosol ; cell surface ; catenin complex ;
Biological process	cell adhesion ; adherens junction organization ; positive regulation of muscle cell differentiation ; homophilic cell adhesion via plasma membrane adhesion molecules ; cell morphogenesis ; cell-cell junction assembly ; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules ; cell-cell adhesion mediated by cadherin ; cell-cell adhesion ;
	Sources:Amigo / QuickGO
Orthologs
	1013
	12555
	ENSG00000129910
	ENSMUSG00000031962
	P55291
	P33146
	NM_004933
	NM_007662
	NP_004924
	NP_031688
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2024

Cadherin-15 is a protein that in humans is encoded by the CDH15 gene.^[5]^[6]

Function

This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation.^[6]

Interactions

CDH15 has been shown to interact with ARVCF.^[7]

Related Research Articles

Cadherin-2 also known as Neural cadherin (N-cadherin), is a protein that in humans is encoded by the CDH2 gene. CDH2 has also been designated as CD325 . Cadherin-2 is a transmembrane protein expressed in multiple tissues and functions to mediate cell–cell adhesion. In cardiac muscle, Cadherin-2 is an integral component in adherens junctions residing at intercalated discs, which function to mechanically and electrically couple adjacent cardiomyocytes. Alterations in expression and integrity of Cadherin-2 has been observed in various forms of disease, including human dilated cardiomyopathy. Variants in CDH2 have also been identified to cause a syndromic neurodevelopmental disorder.

Cadherin-5, or VE-cadherin, also known as CD144, is a type of cadherin. It is encoded by the human gene CDH5.

Cadherin EGF LAG seven-pass G-type receptor 3 is a protein that in humans is encoded by the CELSR3 gene.

Cadherin-3, also known as P-Cadherin, is a protein that in humans is encoded by the CDH3 gene.

Regulator of G-protein signaling 19 is a protein that in humans is encoded by the RGS19 gene.

Cadherin-11 is a protein that in humans is encoded by the CDH11 gene.

Cadherin-4 is a protein that in humans is encoded by the CDH4 gene.

Cadherin-6 is a protein that in humans is encoded by the CDH6 gene.

Armadillo repeat protein deleted in velo-cardio-facial syndrome is a protein that in humans is encoded by the ARVCF gene.

Cadherin-16 is a protein that in humans is encoded by the CDH16 gene.

Cadherin-17 is a protein that in humans is encoded by the CDH17 gene.

Cadherin-12 is a protein that in humans is encoded by the CDH12 gene.

Cell adhesion molecule 3 is a protein that in humans is encoded by the CADM3 gene.

Cadherin-8 is a protein that in humans is encoded by the CDH8 gene.

αE-catenin, also known as Catenin alpha-1 is a protein that in humans is encoded by the CTNNA1 gene. αE-catenin is highly expressed in cardiac muscle and localizes to adherens junctions at intercalated disc structures where it functions to mediate the anchorage of actin filaments to the sarcolemma. αE-catenin also plays a role in tumor metastasis and skin cell function.

Protocadherin beta-15 is a protein that in humans is encoded by the PCDHB15 gene.

Protocadherin beta-12 is a protein that in humans is encoded by the PCDHB12 gene.

Alkaline ceramidase 2 also known as ACER2 is a ceramidase enzyme which in humans is encoded by the ACER2 gene.

Cadherin 10 is a protein that in humans is encoded by the CDH10 gene.

Cadherin 9 is a protein that in humans is encoded by the CDH9 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000129910 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031962 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kaupmann K, Becker-Follmann J, Scherer G, Jockusch H, Starzinski-Powitz A (December 1992). "The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species". Genomics. 14 (2): 488–90. doi:10.1016/S0888-7543(05)80247-2. PMID 1427864.
1 2 "Entrez Gene: CDH15 cadherin 15, M-cadherin (myotubule)".
↑ Kaufmann U, Zuppinger C, Waibler Z, Rudiger M, Urbich C, Martin B, Jockusch BM, Eppenberger H, Starzinski-Powitz A (November 2000). "The armadillo repeat region targets ARVCF to cadherin-based cellular junctions". J. Cell Sci. 113 (22): 4121–35. doi:10.1242/jcs.113.22.4121. PMID 11058098.

External links

CDH15 human gene location in the UCSC Genome Browser .
CDH15 human gene details in the UCSC Genome Browser .
Human CDH3 genome location and CDH3 gene details page in the UCSC Genome Browser .

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000129910 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031962 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1427864-5] Kaupmann K, Becker-Follmann J, Scherer G, Jockusch H, Starzinski-Powitz A (December 1992). "The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species". Genomics. 14 (2): 488–90. doi:10.1016/S0888-7543(05)80247-2. PMID 1427864.

[entrez-6] 1 2 "Entrez Gene: CDH15 cadherin 15, M-cadherin (myotubule)".

[pmid11058098-7] Kaufmann U, Zuppinger C, Waibler Z, Rudiger M, Urbich C, Martin B, Jockusch BM, Eppenberger H, Starzinski-Powitz A (November 2000). "The armadillo repeat region targets ARVCF to cadherin-based cellular junctions". J. Cell Sci. 113 (22): 4121–35. doi:10.1242/jcs.113.22.4121. PMID 11058098.

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