CDH8 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | CDH8 , Nbla04261, cadherin 8 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 603008 MGI: 107434 HomoloGene: 55604 GeneCards: CDH8 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Cadherin-8 is a protein that in humans is encoded by the CDH8 gene. [5] [6] [7]
This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance. [7]
Disruptions of CDH8 in humans have been implicated in autism. [8] [9]
T-cadherin, also known as cadherin 13, H-cadherin (heart), and CDH13, is a unique member of the cadherin superfamily of proteins because it lacks the transmembrane and cytoplasmic domains common to all other cadherins and is instead anchored to the cell's plasma membrane by the GPI anchor.
Cadherin-2 also known as Neural cadherin (N-cadherin), is a protein that in humans is encoded by the CDH2 gene. CDH2 has also been designated as CD325 . Cadherin-2 is a transmembrane protein expressed in multiple tissues and functions to mediate cell–cell adhesion. In cardiac muscle, Cadherin-2 is an integral component in adherens junctions residing at intercalated discs, which function to mechanically and electrically couple adjacent cardiomyocytes. Alterations in expression and integrity of Cadherin-2 has been observed in various forms of disease, including human dilated cardiomyopathy. Variants in CDH2 have also been identified to cause a syndromic neurodevelopmental disorder.
Cadherin-5, or VE-cadherin, also known as CD144, is a type of cadherin. It is encoded by the human gene CDH5.
Cadherin-23 is a protein that in humans is encoded by the CDH23 gene.
Cadherin EGF LAG seven-pass G-type receptor 3 is a protein that in humans is encoded by the CELSR3 gene.
Cadherin EGF LAG seven-pass G-type receptor 2 is a protein that in humans is encoded by the CELSR2 gene.
Cadherin EGF LAG seven-pass G-type receptor 1 also known as flamingo homolog 2 or cadherin family member 9 is a protein that in humans is encoded by the CELSR1 gene.
Cadherin-3, also known as P-Cadherin, is a protein that in humans is encoded by the CDH3 gene.
Cadherin-11 is a protein that in humans is encoded by the CDH11 gene.
Cadherin-4 is a protein that in humans is encoded by the CDH4 gene.
Cadherin-6 is a protein that in humans is encoded by the CDH6 gene.
Cadherin-15 is a protein that in humans is encoded by the CDH15 gene.
Cadherin-16 is a protein that in humans is encoded by the CDH16 gene.
Cadherin-17 is a protein that in humans is encoded by the CDH17 gene.
Protocadherin-1 is a protein that in humans is encoded by the PCDH1 gene.
Protocadherin gamma-C3 is a protein that in humans is encoded by the PCDHGC3 gene.
Cadherin-12 is a protein that in humans is encoded by the CDH12 gene.
Cadherin-1 or Epithelial cadherin(E-cadherin), is a protein that in humans is encoded by the CDH1 gene. Mutations are correlated with gastric, breast, colorectal, thyroid, and ovarian cancers. CDH1 has also been designated as CD324. It is a tumor suppressor gene.
Cadherin 10 is a protein that in humans is encoded by the CDH10 gene.
Cadherin 9 is a protein that in humans is encoded by the CDH9 gene.