CDH16

CDH16
Identifiers
Aliases	CDH16 , cadherin 16
External IDs	OMIM: 603118 MGI: 106671 HomoloGene: 2997 GeneCards: CDH16
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16q22.1 Start 66,908,122 bp [1] End 66,918,917 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8 D3|8 53.04 cM Start 105,328,543 bp [2] End 105,351,028 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in kidney renal medulla kidney tubule left lobe of thyroid gland right lobe of thyroid gland glomerulus metanephric glomerulus caput epididymis right uterine tube duodenum Top expressed in kidney medullary collecting duct proximal tubule vas deferens renal corpuscle left lung lobe renal pelvis trachea epididymis thyroid gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding metal ion binding Cellular component integral component of membrane plasma membrane extracellular exosome membrane integral component of plasma membrane basolateral plasma membrane Biological process calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules cell-cell signaling nervous system development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1014 12556 Ensembl ENSG00000166589 ENSMUSG00000031881 UniProt O75309 O88338 RefSeq (mRNA) NM_001204744 NM_001204745 NM_001204746 NM_004062 NM_001252627 NM_001252628 NM_007663 RefSeq (protein) NP_001191673 NP_001191674 NP_001191675 NP_004053 NP_001239556 NP_001239557 NP_031689 Location (UCSC) Chr 16: 66.91 – 66.92 Mb Chr 8: 105.33 – 105.35 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cadherin-16 is a protein that in humans is encoded by the CDH16 gene. ^{[5] [6] [7]}

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in the kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000166589 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031881 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Thomson RB, Ward DC, Quaggin SE, Igarashi P, Muckler ZE, Aronson PS (Oct 1998). "cDNA cloning and chromosomal localization of the human and mouse isoforms of Ksp-cadherin". Genomics. 51 (3): 445–51. doi:10.1006/geno.1998.5402. PMID   9721215.
6. Thomson RB, Igarashi P, Biemesderfer D, Kim R, Abu-Alfa A, Soleimani M, Aronson PS (Aug 1995). "Isolation and cDNA cloning of Ksp-cadherin, a novel kidney-specific member of the cadherin multigene family". J Biol Chem. 270 (29): 17594–601. doi: 10.1074/jbc.270.29.17594 . PMID   7615566.
7. "Entrez Gene: CDH16 cadherin 16, KSP-cadherin".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Thomson RB, Aronson PS (1999). "Immunolocalization of Ksp-cadherin in the adult and developing rabbit kidney". Am. J. Physiol. 277 (1 Pt 2): F146–56. doi:10.1152/ajprenal.1999.277.1.F146. PMID   10409308.
• Baudry D, Jeanpierre C (2000). "Assignment of E-cadherin (CDH1) and KSP-cadherin (CDH16) to chromosome 16q22.1 by radiation hybrid mapping". Cytogenet. Cell Genet. 88 (3–4): 253–4. doi:10.1159/000015531. PMID   10828602. S2CID   83989085.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Thomson RB, Mentone S, Kim R, et al. (2003). "Histopathological analysis of renal cystic epithelia in the Pkd2WS25/- mouse model of ADPKD". Am. J. Physiol. Renal Physiol. 285 (5): F870–80. doi:10.1152/ajprenal.00153.2003. PMID   12851251.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Wendeler MW, Praus M, Jung R, et al. (2004). "Ksp-cadherin is a functional cell-cell adhesion molecule related to LI-cadherin". Exp. Cell Res. 294 (2): 345–55. doi:10.1016/j.yexcr.2003.11.022. PMID   15023525.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Hishikawa K, Marumo T, Miura S, et al. (2005). "Leukemia inhibitory factor induces multi-lineage differentiation of adult stem-like cells in kidney via kidney-specific cadherin 16". Biochem. Biophys. Res. Commun. 328 (1): 288–91. doi:10.1016/j.bbrc.2004.12.167. PMID   15670782.
• Thedieck C, Kuczyk M, Klingel K, et al. (2005). "Expression of Ksp-cadherin during kidney development and in renal cell carcinoma". Br. J. Cancer. 92 (11): 2010–7. doi:10.1038/sj.bjc.6602597. PMC   2361784 . PMID   15886705.
• Kuehn A, Paner GP, Skinnider BF, et al. (2007). "Expression analysis of kidney-specific cadherin in a wide spectrum of traditional and newly recognized renal epithelial neoplasms: diagnostic and histogenetic implications". Am. J. Surg. Pathol. 31 (10): 1528–33. doi:10.1097/PAS.0b013e318058818c. PMID   17895753. S2CID   46401984.

External links

• CDH16 human gene location in the UCSC Genome Browser .
• CDH16 human gene details in the UCSC Genome Browser .