CDH6

Last updated

CDH6
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CDH6 , CAD6, KCAD, cadherin 6
External IDs OMIM: 603007; MGI: 107435; HomoloGene: 21027; GeneCards: CDH6; OMA:CDH6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004932
NM_001362435

NM_007666

RefSeq (protein)

NP_004923
NP_001349364

NP_031692

Location (UCSC) Chr 5: 31.19 – 31.33 Mb Chr 15: 13.03 – 13.17 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cadherin-6 is a protein that in humans is encoded by the CDH6 gene. [5] [6] [7]

Contents

This gene encodes a type II classical cadherin from the cadherin superfamily. The encoded membrane protein is a calcium dependent cell–cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Cadherins mediate cell–cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. Strong transcriptional expression of this gene has been observed in hepatocellular and renal carcinoma cell lines, suggesting a possible role in metastasis and invasion. [7]

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000113361 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039385 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Shimoyama Y, Gotoh M, Terasaki T, Kitajima M, Hirohashi S (June 1995). "Isolation and sequence analysis of human cadherin-6 complementary DNA for the full coding sequence and its expression in human carcinoma cells". Cancer Res. 55 (10): 2206–11. PMID   7743525.
  6. Chalmers IJ, Hofler H, Atkinson MJ (June 1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma". Genomics. 57 (1): 160–3. doi:10.1006/geno.1998.5717. PMID   10191097.
  7. 1 2 "Entrez Gene: CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)".

Further reading