CDH6

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CDH6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LND
Identifiers
Aliases	CDH6 , CAD6, KCAD, cadherin 6
External IDs	OMIM: 603007 MGI: 107435 HomoloGene: 21027 GeneCards: CDH6
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5p13.3 Start 31,193,686 bp [1] End 31,329,146 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 A1 Start 13,028,787 bp [2] End 13,173,761 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in kidney tubule kidney endothelial cell vena cava gallbladder sural nerve metanephric glomerulus visceral pleura putamen Brodmann area 46 Top expressed in internal carotid artery external carotid artery hair follicle ascending aorta aortic valve renal corpuscle ciliary body iris ureter facial motor nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding metal ion binding cytoskeletal protein binding protein homodimerization activity cadherin binding Cellular component integral component of membrane plasma membrane membrane cell surface catenin complex Biological process Notch signaling pathway cell adhesion adherens junction organization homophilic cell adhesion via plasma membrane adhesion molecules cell-cell junction assembly calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell-cell adhesion mediated by cadherin cell-cell adhesion cell morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1004 12563 Ensembl ENSG00000113361 ENSMUSG00000039385 UniProt P55285 P97326 RefSeq (mRNA) NM_004932 NM_001362435 NM_007666 RefSeq (protein) NP_004923 NP_001349364 NP_031692 Location (UCSC) Chr 5: 31.19 – 31.33 Mb Chr 15: 13.03 – 13.17 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cadherin-6 is a protein that in humans is encoded by the CDH6 gene. ^{[5] [6] [7]}

This gene encodes a type II classical cadherin from the cadherin superfamily. The encoded membrane protein is a calcium dependent cell–cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Cadherins mediate cell–cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. Strong transcriptional expression of this gene has been observed in hepatocellular and renal carcinoma cell lines, suggesting a possible role in metastasis and invasion. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000113361 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039385 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Shimoyama Y, Gotoh M, Terasaki T, Kitajima M, Hirohashi S (June 1995). "Isolation and sequence analysis of human cadherin-6 complementary DNA for the full coding sequence and its expression in human carcinoma cells". Cancer Res. 55 (10): 2206–11. PMID   7743525.
6. Chalmers IJ, Hofler H, Atkinson MJ (June 1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma". Genomics. 57 (1): 160–3. doi:10.1006/geno.1998.5717. PMID   10191097.
7. "Entrez Gene: CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)".

Further reading

• MacCalman CD, Getsios S, Chen GT (1998). "Type 2 cadherins in the human endometrium and placenta: their putative roles in human implantation and placentation". Am. J. Reprod. Immunol. 39 (2): 96–107. doi:10.1111/j.1600-0897.1998.tb00341.x. PMID   9506208. S2CID   23871813.
• Suzuki S, Sano K, Tanihara H (1991). "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue". Cell Regul. 2 (4): 261–70. doi:10.1091/mbc.2.4.261. PMC   361775 . PMID   2059658.
• Paul R, Ewing CM, Robinson JC, et al. (1997). "Cadherin-6, a cell adhesion molecule specifically expressed in the proximal renal tubule and renal cell carcinoma". Cancer Res. 57 (13): 2741–8. PMID   9205085.
• Getsios S, Chen GT, Stephenson MD, et al. (1998). "Regulated expression of cadherin-6 and cadherin-11 in the glandular epithelial and stromal cells of the human endometrium". Dev. Dyn. 211 (3): 238–47. doi:10.1002/(SICI)1097-0177(199803)211:3<238::AID-AJA5>3.0.CO;2-I. PMID   9520111.
• Kremmidiotis G, Baker E, Crawford J, et al. (1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics. 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID   9615235.
• Shimoyama Y, Takeda H, Yoshihara S, et al. (1999). "Biochemical characterization and functional analysis of two type II classic cadherins, cadherin-6 and -14, and comparison with E-cadherin". J. Biol. Chem. 274 (17): 11987–94. doi: 10.1074/jbc.274.17.11987 . PMID   10207020.
• Shimoyama Y, Tsujimoto G, Kitajima M, Natori M (2001). "Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins". Biochem. J. 349 (Pt 1): 159–67. doi:10.1042/0264-6021:3490159. PMC   1221133 . PMID   10861224.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC   1850943 . PMID   16335952.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.

External links

• CDH6 human gene location in the UCSC Genome Browser .
• CDH6 human gene details in the UCSC Genome Browser .