CDH9

CDH9
Identifiers
Aliases	CDH9 , cadherin 9
External IDs	OMIM: 609974; MGI: 107433; HomoloGene: 9450; GeneCards: CDH9; OMA:CDH9 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5p14.1 Start 26,880,597 bp [1] End 27,121,150 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 A2 Start 16,728,842 bp [2] End 16,857,180 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell prefrontal cortex testicle dorsolateral prefrontal cortex anterior cingulate cortex Brodmann area 9 right frontal lobe nucleus accumbens Brodmann area 23 middle temporal gyrus Top expressed in dentate gyrus of hippocampal formation granule cell supraoptic nucleus lumbar spinal ganglion temporal lobe hippocampus proper anterior amygdaloid area prefrontal cortex barrel cortex subiculum substantia nigra More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding metal ion binding molecular function cytoskeletal protein binding protein homodimerization activity cadherin binding Cellular component integral component of membrane plasma membrane membrane integral component of postsynaptic membrane integral component of presynaptic membrane cell surface catenin complex Biological process cell adhesion adherens junction organization homophilic cell adhesion via plasma membrane adhesion molecules cell-cell adhesion synapse assembly synaptic membrane adhesion cell-cell junction assembly calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell-cell adhesion mediated by cadherin cell morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1007 12565 Ensembl ENSG00000113100 ENSMUSG00000025370 UniProt Q9ULB4 P70407 RefSeq (mRNA) NM_016279 NM_009869 RefSeq (protein) NP_057363 NP_033999 Location (UCSC) Chr 5: 26.88 – 27.12 Mb Chr 15: 16.73 – 16.86 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cadherin 9 is a protein that in humans is encoded by the CDH9 gene. ^{[5] [6]}

Clinical significance

An association with autism has been suggested. ^[7]

See also

• Cadherin
• Heritability of autism

References

1. GRCh38: Ensembl release 89: ENSG00000113100 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025370 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: cadherin 9".
6. Suzuki S, Sano K, Tanihara H (April 1991). "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue". Cell Regulation. 2 (4): 261–70. doi:10.1091/mbc.2.4.261. PMC   361775 . PMID   2059658.
7. Wang K, Zhang H, Ma D, Bucan M, Glessner JT, Abrahams BS, et al. (May 2009). "Common genetic variants on 5p14.1 associate with autism spectrum disorders". Nature. 459 (7246): 528–33. Bibcode:2009Natur.459..528W. doi:10.1038/nature07999. PMC   2943511 . PMID   19404256.

External links

• Human CDH9 genome location and CDH9 gene details page in the UCSC Genome Browser .

Further reading

• Nollet F, Kools P, van Roy F (June 2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". Journal of Molecular Biology. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID   10835267.
• Shimoyama Y, Tsujimoto G, Kitajima M, Natori M (July 2000). "Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins". The Biochemical Journal. 349 (Pt 1): 159–67. doi:10.1042/0264-6021:3490159. PMC   1221133 . PMID   10861224.
• Wang K, Zhang H, Bloss CS, Duvvuri V, Kaye W, Schork NJ, Berrettini W, Hakonarson H (September 2011). "A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa". Molecular Psychiatry. 16 (9): 949–59. doi:10.1038/mp.2010.107. PMC   3859494 . PMID   21079607.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Ali J, Liao F, Martens E, Muller WA (June 1997). "Vascular endothelial cadherin (VE-cadherin): cloning and role in endothelial cell-cell adhesion". Microcirculation. 4 (2): 267–77. doi:10.3109/10739689709146790. PMID   9219219. S2CID   21501093.
• Thedieck C, Kalbacher H, Kuczyk M, Müller GA, Müller CA, Klein G (2007). Zoccali C (ed.). "Cadherin-9 is a novel cell surface marker for the heterogeneous pool of renal fibroblasts". PLOS ONE. 2 (7): e657. Bibcode:2007PLoSO...2..657T. doi: 10.1371/journal.pone.0000657 . PMC   1924602 . PMID   17668045.
• Hülsken J, Birchmeier W, Behrens J (December 1994). "E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton". The Journal of Cell Biology. 127 (6 Pt 2): 2061–9. doi:10.1083/jcb.127.6.2061. PMC   2120290 . PMID   7806582.