CDH11

CDH11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2A4C, 2A4E
Identifiers
Aliases	CDH11 , CAD11, CDHOB, OB, OSF-4, cadherin 11, ESWS, TBHS2
External IDs	OMIM: 600023; MGI: 99217; HomoloGene: 1361; GeneCards: CDH11; OMA:CDH11 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16q21 Start 64,943,753 bp [1] End 65,126,112 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8 D1|8 50.44 cM Start 103,358,727 bp [2] End 103,512,274 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in periodontal fiber stromal cell of endometrium tibia visceral pleura Achilles tendon decidua left ovary right ovary germinal epithelium smooth muscle tissue Top expressed in calvaria vas deferens dermis body of femur Gonadal ridge efferent ductule human fetus left lung lobe maxillary prominence molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding calcium ion binding cytoskeletal protein binding protein homodimerization activity cadherin binding Cellular component plasma membrane membrane cytoplasm integral component of membrane extracellular exosome cell surface catenin complex synapse Schaffer collateral - CA1 synapse glutamatergic synapse Biological process homophilic cell adhesion via plasma membrane adhesion molecules skeletal system development adherens junction organization ossification corticospinal tract morphogenesis cell adhesion cell morphogenesis cell-cell junction assembly calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell-cell adhesion mediated by cadherin modulation of chemical synaptic transmission cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1009 12552 Ensembl ENSG00000140937 ENSMUSG00000031673 UniProt P55287 P55288 RefSeq (mRNA) NM_001308392 NM_001797 NM_001330576 NM_033664 NM_009866 RefSeq (protein) NP_001295321 NP_001317505 NP_001788 NP_033996 Location (UCSC) Chr 16: 64.94 – 65.13 Mb Chr 8: 103.36 – 103.51 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cadherin-11 is a protein that in humans is encoded by the CDH11 gene. ^{[5] [6]}

Function

This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. ^[6] The mammalian CDH-11 homologues are termed calsyntenin. ^[7]

Relevance to cancer

CDH11 is overexpressed in 15% of breast cancers and seems essential to tumour progression in some other cancer types. ^{[8] [9]}

Drug interactions

Arthritis drug celecoxib binds to CDH11. ^{[8] [9]}

Interactions

CDH11 has been shown to interact with CDH2. ^[10]

References

1. GRCh38: Ensembl release 89: ENSG00000140937 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031673 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF (Aug 1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics. 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID   9615235.
6. "Entrez Gene: CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)".
7. Vogt L, Schrimpf SP, Meskenaite V, Frischknecht R, Kinter J, Leone DP, Ziegler U, Sonderegger P (2001). "Calsyntenin-1, a proteolytically processed postsynaptic membrane protein with a cytoplasmic calcium-binding domain". Mol. Cell. Neurosci. 17 (1): 151–66. doi:10.1006/mcne.2000.0937. PMID   11161476. S2CID   30856590.
8. "New Therapeutic Approach Could Target Both Cancer and Arthritis". 15 Nov 2013.
9. Assefnia S, Dakshanamurthy S, Guidry Auvil JM, Hampel C, Anastasiadis PZ, Kallakury B, Uren A, Foley DW, Brown ML, Shapiro L, Brenner M, Haigh D, Byers SW (Mar 2014). "Cadherin-11 in poor prognosis malignancies and rheumatoid arthritis: common target, common therapies". Oncotarget. 5 (6): 1458–74. doi:10.18632/oncotarget.1538. PMC   4039224 . PMID   24681547.
10. Straub BK, Boda J, Kuhn C, Schnoelzer M, Korf U, Kempf T, Spring H, Hatzfeld M, Franke WW (Dec 2003). "A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells". J. Cell Sci. 116 (Pt 24): 4985–95. doi: 10.1242/jcs.00815 . PMID   14625392.

Further reading

• Suzuki S, Sano K, Tanihara H (1991). "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue". Cell Regul. 2 (4): 261–70. doi:10.1091/mbc.2.4.261. PMC   361775 . PMID   2059658.
• Tanihara H, Sano K, Heimark RL, St John T, Suzuki S (1995). "Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin". Cell Adhes. Commun. 2 (1): 15–26. doi:10.3109/15419069409014199. PMID   7982033.
• Okazaki M, Takeshita S, Kawai S, Kikuno R, Tsujimura A, Kudo A, Amann E (1994). "Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts". J. Biol. Chem. 269 (16): 12092–8. doi: 10.1016/S0021-9258(17)32685-6 . PMID   8163513.
• Getsios S, Chen GT, Stephenson MD, Leclerc P, Blaschuk OW, MacCalman CD (1998). "Regulated expression of cadherin-6 and cadherin-11 in the glandular epithelial and stromal cells of the human endometrium". Dev. Dyn. 211 (3): 238–47. doi:10.1002/(SICI)1097-0177(199803)211:3<238::AID-AJA5>3.0.CO;2-I. PMID   9520111. S2CID   43022919.
• Pishvaian MJ, Feltes CM, Thompson P, Bussemakers MJ, Schalken JA, Byers SW (1999). "Cadherin-11 is expressed in invasive breast cancer cell lines". Cancer Res. 59 (4): 947–52. PMID   10029089.
• Kawaguchi J, Takeshita S, Kashima T, Imai T, Machinami R, Kudo A (1999). "Expression and function of the splice variant of the human cadherin-11 gene in subordination to intact cadherin-11". J. Bone Miner. Res. 14 (5): 764–75. doi: 10.1359/jbmr.1999.14.5.764 . PMID   10320525. S2CID   12829659.
• Braungart E, Schumacher C, Hartmann E, Nekarda H, Becker KF, Höfler H, Atkinson MJ (2000). "Functional loss of E-cadherin and cadherin-11 alleles on chromosome 16q22 in colonic cancer". J. Pathol. 187 (5): 530–4. doi:10.1002/(SICI)1096-9896(199904)187:5<530::AID-PATH293>3.0.CO;2-C. PMID   10398117. S2CID   22384331.
• Kashima T, Kawaguchi J, Takeshita S, Kuroda M, Takanashi M, Horiuchi H, Imamura T, Ishikawa Y, Ishida T, Mori S, Machinami R, Kudo A (1999). "Anomalous cadherin expression in osteosarcoma. Possible relationships to metastasis and morphogenesis". Am. J. Pathol. 155 (5): 1549–55. doi:10.1016/S0002-9440(10)65471-5. PMC   1866957 . PMID   10550312.
• Lecanda F, Cheng SL, Shin CS, Davidson MK, Warlow P, Avioli LV, Civitelli R (2000). "Differential regulation of cadherins by dexamethasone in human osteoblastic cells". J. Cell. Biochem. 77 (3): 499–506. doi:10.1002/(SICI)1097-4644(20000601)77:3<499::AID-JCB14>3.0.CO;2-0. PMID   10760957. S2CID   13331343.
• Braungart E, Hartman E, Bechler K, Höfler H, Atkinson MJ (2002). "The intracellular domain of cadherin-11 is not required for the induction of cell aggregation, adhesion or gap-junction formation". Cell Commun. Adhes. 8 (1): 15–27. doi:10.3109/15419060109080704. PMID   11775026. S2CID   23322445.
• Straub BK, Boda J, Kuhn C, Schnoelzer M, Korf U, Kempf T, Spring H, Hatzfeld M, Franke WW (2004). "A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells". J. Cell Sci. 116 (Pt 24): 4985–95. doi: 10.1242/jcs.00815 . PMID   14625392.
• Morimoto AM, Tan N, West K, McArthur G, Toner GC, Manning WC, Smolich BD, Cherrington JM (2004). "Gene expression profiling of human colon xenograft tumors following treatment with SU11248, a multitargeted tyrosine kinase inhibitor". Oncogene. 23 (8): 1618–26. doi:10.1038/sj.onc.1207268. PMID   14985702. S2CID   23251484.
• Marchong MN, Chen D, Corson TW, Lee C, Harmandayan M, Bowles E, Chen N, Gallie BL (2005). "Minimal 16q genomic loss implicates cadherin-11 in retinoblastoma". Mol. Cancer Res. 2 (9): 495–503. doi: 10.1158/1541-7786.495.2.9 . PMID   15383628. S2CID   24674595.
• Oliveira AM, Perez-Atayde AR, Inwards CY, Medeiros F, Derr V, Hsi BL, Gebhardt MC, Rosenberg AE, Fletcher JA (2004). "USP6 and CDH11 oncogenes identify the neoplastic cell in primary aneurysmal bone cysts and are absent in so-called secondary aneurysmal bone cysts". Am. J. Pathol. 165 (5): 1773–80. doi:10.1016/S0002-9440(10)63432-3. PMC   3278819 . PMID   15509545.
• Kiener HP, Brenner MB (2005). "Building the synovium: cadherin-11 mediates fibroblast-like synoviocyte cell-to-cell adhesion". Arthritis Research & Therapy . 7 (2): 49–54. doi: 10.1186/ar1495 . PMC   1065331 . PMID   15743489.
• Kiener HP, Lee DM, Agarwal SK, Brenner MB (2006). "Cadherin-11 induces rheumatoid arthritis fibroblast-like synoviocytes to form lining layers in vitro". Am. J. Pathol. 168 (5): 1486–99. doi:10.2353/ajpath.2006.050999. PMC   1606584 . PMID   16651616.

External links

• CDH11 human gene location in the UCSC Genome Browser .
• CDH11 human gene details in the UCSC Genome Browser .