ICAM5

ICAM5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3BN3, 4OI9, 4OIA, 4OIB
Identifiers
Aliases	ICAM5 , TLCN, TLN, intercellular adhesion molecule 5
External IDs	OMIM: 601852; MGI: 109430; HomoloGene: 2447; GeneCards: ICAM5; OMA:ICAM5 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.2 Start 10,289,952 bp [1] End 10,296,778 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9 A3|9 7.7 cM Start 20,943,369 bp [2] End 20,950,332 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right frontal lobe prefrontal cortex cingulate gyrus anterior cingulate cortex nucleus accumbens dorsolateral prefrontal cortex Brodmann area 9 caudate nucleus frontal pole hippocampus proper Top expressed in entorhinal cortex perirhinal cortex CA3 field dentate gyrus of hippocampal formation granule cell superior frontal gyrus primary visual cortex hippocampus proper Region I of hippocampus proper nucleus accumbens prefrontal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function integrin binding protein binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process cell adhesion phagocytosis regulation of immune response extracellular matrix organization cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7087 15898 Ensembl ENSG00000105376 ENSMUSG00000032174 UniProt Q9UMF0 Q60625 RefSeq (mRNA) NM_003259 NM_008319 RefSeq (protein) NP_003250 NP_032345 Location (UCSC) Chr 19: 10.29 – 10.3 Mb Chr 9: 20.94 – 20.95 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Intercellular adhesion molecule 5 is a protein that in humans is encoded by the ICAM5 gene. ^{[5] [6] [7]}

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases. ^[7]

Studies mentioned a role for ICAM5 in cell adhesion and cell signalling and dysregulation and disfunction of it will increase the risk of breast cancer. ^[8] Study of the association between polymorphisms and breast cancer has been shown that ICAM5 rs1056538 and ICAM5 rs281439 variants might contribute the most in the development of breast cancer. ^[9]

Interactions

ICAM5 has been shown to interact with PSEN1. ^[10]

References

1. GRCh38: Ensembl release 89: ENSG00000105376 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032174 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mizuno T, Yoshihara Y, Inazawa J, Kagamiyama H, Mori K (Feb 1997). "cDNA cloning and chromosomal localization of the human telencephalin and its distinctive interaction with lymphocyte function-associated antigen-1". J Biol Chem. 272 (2): 1156–63. doi: 10.1074/jbc.272.2.1156 . PMID   8995416.
6. Kilgannon P, Turner T, Meyer J, Wisdom W, Gallatin WM (Jan 1999). "Mapping of the ICAM-5 (telencephalin) gene, a neuronal member of the ICAM family, to a location between ICAM-1 and ICAM-3 on human chromosome 19p13.2". Genomics. 54 (2): 328–30. doi:10.1006/geno.1998.5565. PMID   9828136.
7. "Entrez Gene: ICAM5 intercellular adhesion molecule 5, telencephalin".
8. Kammerer, Stefan; Roth, Richard B.; Reneland, Richard; Marnellos, George; Hoyal, Carolyn R.; Markward, Nathan J.; Ebner, Florian; Kiechle, Marion; Schwarz-Boeger, Ulrike; Griffiths, Lyn R.; Ulbrich, Christian; Chrobok, Korbinian; Forster, Gerhard; Praetorius, Georg M.; Meyer, Peter (2004-12-16). "Large-Scale Association Study Identifies ICAM Gene Region as Breast and Prostate Cancer Susceptibility Locus" . Cancer Research. 64 (24): 8906–8910. doi:10.1158/0008-5472.CAN-04-1788. ISSN   0008-5472.
9. Liu, Lin; Sun, Meili; Song, Degang; Wang, Zhehai (2013-02-01). "The genetic polymorphisms of intercellular cell adhesion molecules and breast cancer susceptibility: a meta-analysis" . Molecular Biology Reports. 40 (2): 1855–1860. doi:10.1007/s11033-012-2241-4. ISSN   1573-4978.
10. Annaert, W G; Esselens C; Baert V; Boeve C; Snellings G; Cupers P; Craessaerts K; De Strooper B (Nov 2001). "Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins". Neuron. 32 (4): 579–89. doi: 10.1016/S0896-6273(01)00512-8 . ISSN   0896-6273. PMID   11719200. S2CID   2096602.

Further reading

• Yoshihara Y, Mori K (1995). "Telencephalin: a neuronal area code molecule?". Neurosci. Res. 21 (2): 119–24. doi:10.1016/0168-0102(94)90153-8. PMID   7724062. S2CID   19931440.
• Hayflick JS, Kilgannon P, Gallatin WM (1998). "The intercellular adhesion molecule (ICAM) family of proteins. New members and novel functions". Immunol. Res. 17 (3): 313–27. doi:10.1007/BF02786454. PMID   9638475. S2CID   19901365.
• Benson DL, Yoshihara Y, Mori K (1998). "Polarized distribution and cell type-specific localization of telencephalin, an intercellular adhesion molecule". J. Neurosci. Res. 52 (1): 43–53. doi: 10.1002/(SICI)1097-4547(19980401)52:1<43::AID-JNR5>3.0.CO;2-K . PMID   9556028. S2CID   22675478.
• Rieckmann P, Turner T, Kligannon P, Steinhoff BJ (1998). "Telencephalin as an indicator for temporal-lobe dysfunction". Lancet. 352 (9125): 370–1. doi:10.1016/S0140-6736(05)60469-2. PMID   9717930. S2CID   6255738.
• Arii N, Mizuguchi M, Mori K, Takashima S (1999). "Development of telencephalin in the human cerebrum". Microsc. Res. Tech. 46 (1): 18–23. doi:10.1002/(SICI)1097-0029(19990701)46:1<18::AID-JEMT2>3.0.CO;2-G. PMID   10402269. S2CID   22133468.
• Mizuno T, Yoshihara Y, Kagamiyama H, et al. (2000). "Neuronal adhesion molecule telencephalin induces rapid cell spreading of microglia". Brain Res. 849 (1–2): 58–66. doi:10.1016/S0006-8993(99)01984-8. PMID   10592287. S2CID   353053.
• Tian L, Kilgannon P, Yoshihara Y, et al. (2000). "Binding of T lymphocytes to hippocampal neurons through ICAM-5 (telencephalin) and characterization of its interaction with the leukocyte integrin CD11a/CD18". Eur. J. Immunol. 30 (3): 810–8. doi: 10.1002/1521-4141(200003)30:3<810::AID-IMMU810>3.0.CO;2-X . PMID   10741396.
• Tian L, Nyman H, Kilgannon P, et al. (2000). "Intercellular adhesion molecule-5 induces dendritic outgrowth by homophilic adhesion". J. Cell Biol. 150 (1): 243–52. doi:10.1083/jcb.150.1.243. PMC   2185561 . PMID   10893271.
• Annaert WG, Esselens C, Baert V, et al. (2002). "Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins". Neuron. 32 (4): 579–89. doi: 10.1016/S0896-6273(01)00512-8 . PMID   11719200. S2CID   2096602.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID   12665801. S2CID   23783563.
• Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID   15144186.
• Cox DG, Hankinson SE, Hunter DJ (2006). "Polymorphisms in the ICAM gene locus are not associated with breast cancer Risk". Cancer Epidemiol. Biomarkers Prev. 15 (1): 178–9. doi: 10.1158/1055-9965.EPI-05-0790 . PMID   16434609.