ICAM5

ICAM5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3BN3, 4OI9, 4OIA, 4OIB
Identifiers
Aliases	ICAM5 , TLCN, TLN, intercellular adhesion molecule 5
External IDs	OMIM: 601852 MGI: 109430 HomoloGene: 2447 GeneCards: ICAM5
Gene location (Human)
Chr.	Chromosome 19 (human)
End	10,296,778 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	20,950,332 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; cingulate gyrus; ; nucleus accumbens; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; caudate nucleus; ; frontal pole; ; hippocampus proper; ; middle frontal gyrus; ; amygdala;
	Top expressed in
	entorhinal cortex; ; superior frontal gyrus; ; hippocampus proper; ; Region I of hippocampus proper; ; nucleus accumbens; ; prefrontal cortex; ; amygdala; ; cingulate gyrus; ; primary motor cortex; ; subiculum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	integrin binding ; protein binding ;
Cellular component	integral component of membrane ; plasma membrane ; integral component of plasma membrane ; membrane ;
Biological process	cell adhesion ; phagocytosis ; regulation of immune response ; extracellular matrix organization ; cell-cell adhesion ;
	Sources:Amigo / QuickGO
Orthologs
	7087
	15898
	ENSG00000105376
	ENSMUSG00000032174
	Q9UMF0
	Q60625
	NM_003259
	NM_008319
	NP_003250
	NP_032345
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 30, 2022

Intercellular adhesion molecule 5 is a protein that in humans is encoded by the ICAM5 gene.^[5]^[6]^[7]

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases.^[7]

Interactions

ICAM5 has been shown to interact with PSEN1.^[8]

Related Research Articles

DSCAM and Dscam are both abbreviations for Down syndrome cell adhesion molecule. In humans, DSCAM refers to a gene that encodes one of several protein isoforms.

Platelet endothelial cell adhesion molecule (PECAM-1) also known as cluster of differentiation 31 (CD31) is a protein that in humans is encoded by the PECAM1 gene found on chromosome17q23.3. PECAM-1 plays a key role in removing aged neutrophils from the body.

ICAM-1 also known as CD54 is a protein that in humans is encoded by the ICAM1 gene. This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by rhinovirus as a receptor for entry into respiratory epithelium.

Vascular cell adhesion protein 1 also known as vascular cell adhesion molecule 1 (VCAM-1) or cluster of differentiation 106 (CD106) is a protein that in humans is encoded by the VCAM1 gene. VCAM-1 functions as a cell adhesion molecule.

CD11c, also known as Integrin, alpha X (ITGAX), is a gene that encodes for CD11c.

Integrin, alpha L , also known as ITGAL, is a protein that in human is encoded by ITGAL gene. CD11a functions in the immune system. It is involved in cellular adhesion and costimulatory signaling. It is the target of the drug efalizumab.

Myelin-associated glycoprotein is a type 1 transmembrane protein glycoprotein localized in periaxonal Schwann cell and oligodendrocyte membranes, where it plays a role in glial-axonal interactions. MAG is a member of the SIGLEC family of proteins and is a functional ligand of the NOGO-66 receptor, NgR. MAG is believed to be involved in myelination during nerve regeneration in the PNS and is vital for the long-term survival of the myelinated axons following myelinogenesis. In the CNS MAG is one of three main myelin-associated inhibitors of axonal regeneration after injury, making it an important protein for future research on neurogenesis in the CNS.

In molecular biology, CD18 is an integrin beta chain protein that is encoded by the ITGB2 gene in humans. Upon binding with one of a number of alpha chains, CD18 is capable of forming multiple heterodimers, which play significant roles in cellular adhesion and cell surface signaling, as well as important roles in immune responses. CD18 also exists in soluble, ligand binding forms. Deficiencies in CD18 expression can lead to adhesion defects in circulating white blood cells in humans, reducing the immune system's ability to fight off foreign invaders.

Intercellular adhesion molecule 3 (ICAM3) also known as CD50, is a protein that in humans is encoded by the ICAM3 gene. The protein is constitutively expressed on the surface of leukocytes, which are also called white blood cells and are part of the immune system. ICAM3 mediates adhesion between cells by binding to specific integrin receptors. It plays an important role in the immune cell response through its facilitation of interactions between T cells and dendritic cells, which allows for T cell activation. ICAM3 also mediates the clearance of cells undergoing apoptosis by attracting and binding macrophages, a type of cell that breaks down infected or dying cells through a process known as phagocytosis, to apoptotic cells.

Ephrin-B1 is a protein that in humans is encoded by the EFNB1 gene. It is a member of the ephrin family. The encoded protein is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhesion and function in the development or maintenance of the nervous system.

Intercellular adhesion molecule 2 (ICAM2), also known as CD102, is a human gene, and the protein resulting from it.

C-type lectin domain family 4 member M is a protein that in humans is encoded by the CLEC4M gene. CLEC4M has also been designated as CD299.

Cadherin EGF LAG seven-pass G-type receptor 1 also known as flamingo homolog 2 or cadherin family member 9 is a protein that in humans is encoded by the CELSR1 gene.

Contactin 1, also known as CNTN1, is a protein which in humans is encoded by the CNTN1 gene.

CD166 antigen is a 100-105 kD typeI transmembrane glycoprotein that is a member of the immunoglobulin superfamily of proteins. In humans it is encoded by the ALCAM gene. It is also called CD166, MEMD, SC-1/DM-GRASP/BEN in the chicken, and KG-CAM in the rat.

Contactin-2 is a protein that in humans is encoded by the CNTN2 gene.

Junctional adhesion molecule B is a protein that in humans is encoded by the JAM2 gene. JAM2 has also been designated as CD322.

Glutamate receptor-interacting protein 1 is a protein that in humans is encoded by the GRIP1 gene.

Disks large-associated protein 4 (DAP-4) also known as SAP90/PSD-95-associated protein 4 (SAPAP-4) is a protein that in humans is encoded by the DLGAP4 gene.

Ninjurin-1 is a protein that in humans is encoded by the NINJ1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000105376 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032174 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Mizuno T, Yoshihara Y, Inazawa J, Kagamiyama H, Mori K (Feb 1997). "cDNA cloning and chromosomal localization of the human telencephalin and its distinctive interaction with lymphocyte function-associated antigen-1". J Biol Chem. 272 (2): 1156–63. doi: 10.1074/jbc.272.2.1156 . PMID 8995416.
↑ Kilgannon P, Turner T, Meyer J, Wisdom W, Gallatin WM (Jan 1999). "Mapping of the ICAM-5 (telencephalin) gene, a neuronal member of the ICAM family, to a location between ICAM-1 and ICAM-3 on human chromosome 19p13.2". Genomics. 54 (2): 328–30. doi:10.1006/geno.1998.5565. PMID 9828136.
1 2 "Entrez Gene: ICAM5 intercellular adhesion molecule 5, telencephalin".
↑ Annaert, W G; Esselens C; Baert V; Boeve C; Snellings G; Cupers P; Craessaerts K; De Strooper B (Nov 2001). "Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins". Neuron. 32 (4): 579–89. doi: 10.1016/S0896-6273(01)00512-8 . ISSN 0896-6273. PMID 11719200. S2CID 2096602.

Yoshihara Y, Mori K (1995). "Telencephalin: a neuronal area code molecule?". Neurosci. Res. 21 (2): 119–24. doi:10.1016/0168-0102(94)90153-8. PMID 7724062. S2CID 19931440.
Hayflick JS, Kilgannon P, Gallatin WM (1998). "The intercellular adhesion molecule (ICAM) family of proteins. New members and novel functions". Immunol. Res. 17 (3): 313–27. doi:10.1007/BF02786454. PMID 9638475. S2CID 19901365.
Benson DL, Yoshihara Y, Mori K (1998). "Polarized distribution and cell type-specific localization of telencephalin, an intercellular adhesion molecule". J. Neurosci. Res. 52 (1): 43–53. doi:10.1002/(SICI)1097-4547(19980401)52:1<43::AID-JNR5>3.0.CO;2-K. PMID 9556028. S2CID 22675478.
Rieckmann P, Turner T, Kligannon P, Steinhoff BJ (1998). "Telencephalin as an indicator for temporal-lobe dysfunction". Lancet. 352 (9125): 370–1. doi:10.1016/S0140-6736(05)60469-2. PMID 9717930. S2CID 6255738.
Arii N, Mizuguchi M, Mori K, Takashima S (1999). "Development of telencephalin in the human cerebrum". Microsc. Res. Tech. 46 (1): 18–23. doi:10.1002/(SICI)1097-0029(19990701)46:1<18::AID-JEMT2>3.0.CO;2-G. PMID 10402269. S2CID 22133468.
Mizuno T, Yoshihara Y, Kagamiyama H, et al. (2000). "Neuronal adhesion molecule telencephalin induces rapid cell spreading of microglia". Brain Res. 849 (1–2): 58–66. doi:10.1016/S0006-8993(99)01984-8. PMID 10592287. S2CID 353053.
Tian L, Kilgannon P, Yoshihara Y, et al. (2000). "Binding of T lymphocytes to hippocampal neurons through ICAM-5 (telencephalin) and characterization of its interaction with the leukocyte integrin CD11a/CD18". Eur. J. Immunol. 30 (3): 810–8. doi: 10.1002/1521-4141(200003)30:3<810::AID-IMMU810>3.0.CO;2-X . PMID 10741396.
Tian L, Nyman H, Kilgannon P, et al. (2000). "Intercellular adhesion molecule-5 induces dendritic outgrowth by homophilic adhesion". J. Cell Biol. 150 (1): 243–52. doi:10.1083/jcb.150.1.243. PMC 2185561 . PMID 10893271.
Annaert WG, Esselens C, Baert V, et al. (2002). "Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins". Neuron. 32 (4): 579–89. doi: 10.1016/S0896-6273(01)00512-8 . PMID 11719200. S2CID 2096602.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Cox DG, Hankinson SE, Hunter DJ (2006). "Polymorphisms in the ICAM gene locus are not associated with breast cancer Risk". Cancer Epidemiol. Biomarkers Prev. 15 (1): 178–9. doi: 10.1158/1055-9965.EPI-05-0790 . PMID 16434609.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000105376 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032174 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8995416-5] Mizuno T, Yoshihara Y, Inazawa J, Kagamiyama H, Mori K (Feb 1997). "cDNA cloning and chromosomal localization of the human telencephalin and its distinctive interaction with lymphocyte function-associated antigen-1". J Biol Chem. 272 (2): 1156–63. doi: 10.1074/jbc.272.2.1156 . PMID 8995416.

[pmid9828136-6] Kilgannon P, Turner T, Meyer J, Wisdom W, Gallatin WM (Jan 1999). "Mapping of the ICAM-5 (telencephalin) gene, a neuronal member of the ICAM family, to a location between ICAM-1 and ICAM-3 on human chromosome 19p13.2". Genomics. 54 (2): 328–30. doi:10.1006/geno.1998.5565. PMID 9828136.

[entrez-7] 1 2 "Entrez Gene: ICAM5 intercellular adhesion molecule 5, telencephalin".

[pmid11719200-8] Annaert, W G; Esselens C; Baert V; Boeve C; Snellings G; Cupers P; Craessaerts K; De Strooper B (Nov 2001). "Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins". Neuron. 32 (4): 579–89. doi: 10.1016/S0896-6273(01)00512-8 . ISSN 0896-6273. PMID 11719200. S2CID 2096602.

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ICAM5

Contents

Interactions

Related Research Articles

References

Further reading