CD84

CD84
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2PKD
Identifiers
Aliases	CD84 , LY9B, SLAMF5, hmCD84 molecule
External IDs	OMIM: 604513; MGI: 1336885; HomoloGene: 48249; GeneCards: CD84; OMA:CD84 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	160,579,516 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	171,718,285 bp
RNA expression pattern
	Top expressed in
	tibia; ; lymph node; ; monocyte; ; periodontal fiber; ; appendix; ; trabecular bone; ; superficial temporal artery; ; synovial membrane; ; visceral pleura; ; synovial joint;
	Top expressed in
	stroma of bone marrow; ; granulocyte; ; blood; ; calvaria; ; thymus; ; tibiofemoral joint; ; spleen; ; body of femur; ; mesenteric lymph nodes; ; subcutaneous adipose tissue;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding ; identical protein binding ;
Cellular component	integral component of membrane ; plasma membrane ; integral component of plasma membrane ; membrane ;
Biological process	negative regulation of granulocyte macrophage colony-stimulating factor production ; defense response ; innate immune response ; negative regulation of interleukin-18 production ; cell adhesion ; adaptive immune response ; negative regulation of mast cell degranulation ; regulation of store-operated calcium entry ; negative regulation of mast cell activation ; leukocyte migration ; homophilic cell adhesion via plasma membrane adhesion molecules ; immune system process ; autophagy ;
	Sources:Amigo / QuickGO
Orthologs
	8832
	12523
	ENSG00000066294
	ENSMUSG00000038147
	Q9UIB8
	Q18PI6
	NM_001184879 ; NM_001184881 ; NM_001184882 ; NM_003874 ; NM_001330742 Contents Function ; Interactions ; See also ; References ; Further reading ; External links ;
	NM_001252472 ; NM_001289470 ; NM_013489
	NP_001171808 ; NP_001171810 ; NP_001171811 ; NP_001317671 ; NP_003865
	NP_001239401 ; NP_001276399 ; NP_038517
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated July 18, 2025

CD84 (Cluster of Differentiation 84) is a human protein encoded by the CD84 gene.^[5]

Function

Members of the CD2 (see MIM 186990) subgroup of the Ig superfamily, such as CD84, have similar patterns of conserved disulfide bonds and function in adhesion interactions between T lymphocytes and accessory cells.^[5]

Interactions

CD84 has been shown to interact with SH2D1A.^[6]^[7]^[8]^[9]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000066294 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038147 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: CD84 CD84 molecule".
↑ Tangye SG, Nichols KE, Hare NJ, van de Weerdt BC (Sep 2003). "Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation". Journal of Immunology. 171 (5): 2485–95. doi: 10.4049/jimmunol.171.5.2485 . PMID 12928397.
↑ Sayós J, Martín M, Chen A, Simarro M, Howie D, Morra M, Engel P, Terhorst C (Jun 2001). "Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP". Blood. 97 (12): 3867–74. doi: 10.1182/blood.V97.12.3867 . PMID 11389028. S2CID 10530544.
↑ Tangye SG, van de Weerdt BC, Avery DT, Hodgkin PD (Jun 2002). "CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2". European Journal of Immunology. 32 (6): 1640–9. doi: 10.1002/1521-4141(200206)32:6<1640::AID-IMMU1640>3.0.CO;2-S . PMID 12115647.
↑ Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, Sumegi J, Engel P, Li SC, Terhorst C (Sep 2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients" (PDF). The Journal of Biological Chemistry. 276 (39): 36809–16. doi: 10.1074/jbc.M101305200 . PMID 11477068. S2CID 39889619.

Andreesen R, Bross KJ, Osterholz J, Emmrich F (May 1986). "Human macrophage maturation and heterogeneity: analysis with a newly generated set of monoclonal antibodies to differentiation antigens". Blood. 67 (5): 1257–64. doi: 10.1182/blood.V67.5.1257.1257 . PMID 3008886.
Kingsmore SF, Souryal CA, Watson ML, Patel DD, Seldin MF (1995). "Physical and genetic linkage of the genes encoding Ly-9 and CD48 on mouse and human chromosomes 1". Immunogenetics. 42 (1): 59–62. doi:10.1007/BF00164988. PMID 7797269. S2CID 28529549.
de la Fuente MA, Pizcueta P, Nadal M, Bosch J, Engel P (Sep 1997). "CD84 leukocyte antigen is a new member of the Ig superfamily". Blood. 90 (6): 2398–405. doi: 10.1182/blood.V90.6.2398 . PMID 9310491.
Krause SW, Rehli M, Heinz S, Ebner R, Andreesen R (Mar 2000). "Characterization of MAX.3 antigen, a glycoprotein expressed on mature macrophages, dendritic cells and blood platelets: identity with CD84". The Biochemical Journal. 346 Pt 3 (3): 729–36. doi:10.1042/0264-6021:3460729. PMC 1220906 . PMID 10698700.
Palou E, Pirotto F, Solé J, Freed JH, Peral B, Vilardell C, Vilella R, Vives J, Gayá A (Feb 2000). "Genomic characterization of CD84 reveals the existence of five isoforms differing in their cytoplasmic domains". Tissue Antigens. 55 (2): 118–27. doi:10.1034/j.1399-0039.2000.550203.x. PMID 10746783.
Lucas AD, Chadwick N, Warren BF, Jewell DP, Gordon S, Powrie F, Greaves DR (Mar 2001). "The transmembrane form of the CX3CL1 chemokine fractalkine is expressed predominantly by epithelial cells in vivo". The American Journal of Pathology. 158 (3): 855–66. doi:10.1016/S0002-9440(10)64034-5. PMC 1850344 . PMID 11238035.
Shlapatska LM, Mikhalap SV, Berdova AG, Zelensky OM, Yun TJ, Nichols KE, Clark EA, Sidorenko SP (May 2001). "CD150 association with either the SH2-containing inositol phosphatase or the SH2-containing protein tyrosine phosphatase is regulated by the adaptor protein SH2D1A". Journal of Immunology. 166 (9): 5480–7. doi: 10.4049/jimmunol.166.9.5480 . PMID 11313386.
Sayós J, Martín M, Chen A, Simarro M, Howie D, Morra M, Engel P, Terhorst C (Jun 2001). "Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP". Blood. 97 (12): 3867–74. doi: 10.1182/blood.V97.12.3867 . PMID 11389028. S2CID 10530544.
Lewis J, Eiben LJ, Nelson DL, Cohen JI, Nichols KE, Ochs HD, Notarangelo LD, Duckett CS (Jul 2001). "Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family". Clinical Immunology. 100 (1): 15–23. doi:10.1006/clim.2001.5035. PMID 11414741.
Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, Sumegi J, Engel P, Li SC, Terhorst C (Sep 2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients" (PDF). The Journal of Biological Chemistry. 276 (39): 36809–16. doi: 10.1074/jbc.M101305200 . PMID 11477068. S2CID 39889619.
Martin M, Romero X, de la Fuente MA, Tovar V, Zapater N, Esplugues E, Pizcueta P, Bosch J, Engel P (Oct 2001). "CD84 functions as a homophilic adhesion molecule and enhances IFN-gamma secretion: adhesion is mediated by Ig-like domain 1". Journal of Immunology. 167 (7): 3668–76. doi: 10.4049/jimmunol.167.7.3668 . PMID 11564780.
Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, Denny C, Yaffe MB, Engel P, Eck MJ, Terhorst C (Nov 2001). "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells". The EMBO Journal. 20 (21): 5840–52. doi:10.1093/emboj/20.21.5840. PMC 125701 . PMID 11689425.
Tangye SG, van de Weerdt BC, Avery DT, Hodgkin PD (Jun 2002). "CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2". European Journal of Immunology. 32 (6): 1640–9. doi: 10.1002/1521-4141(200206)32:6<1640::AID-IMMU1640>3.0.CO;2-S . PMID 12115647.
Del Valle JM, Engel P, Martín M (May 2003). "The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2)". The Journal of Biological Chemistry. 278 (19): 17430–7. doi: 10.1074/jbc.M301569200 . PMID 12621057.
Tangye SG, Nichols KE, Hare NJ, van de Weerdt BC (Sep 2003). "Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation". Journal of Immunology. 171 (5): 2485–95. doi: 10.4049/jimmunol.171.5.2485 . PMID 12928397.
Zaiss M, Hirtreiter C, Rehli M, Rehm A, Kunz-Schughart LA, Andreesen R, Hennemann B (Sep 2003). "CD84 expression on human hematopoietic progenitor cells". Experimental Hematology. 31 (9): 798–805. doi: 10.1016/S0301-472X(03)00187-5 . PMID 12962726.
Romero X, Benítez D, March S, Vilella R, Miralpeix M, Engel P (Aug 2004). "Differential expression of SAP and EAT-2-binding leukocyte cell-surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4)". Tissue Antigens. 64 (2): 132–44. doi:10.1111/j.1399-0039.2004.00247.x. PMID 15245368.
Nanda N, Andre P, Bao M, Clauser K, Deguzman F, Howie D, Conley PB, Terhorst C, Phillips DR (Nov 2005). "Platelet aggregation induces platelet aggregate stability via SLAM family receptor signaling". Blood. 106 (9): 3028–34. doi: 10.1182/blood-2005-01-0333 . PMID 16037392.

External links

CD84+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CD84 genome location and CD84 gene details page in the UCSC Genome Browser .

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000066294 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038147 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: CD84 CD84 molecule".

[pmid12928397-6] Tangye SG, Nichols KE, Hare NJ, van de Weerdt BC (Sep 2003). "Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation". Journal of Immunology. 171 (5): 2485–95. doi: 10.4049/jimmunol.171.5.2485 . PMID 12928397.

[pmid11389028-7] Sayós J, Martín M, Chen A, Simarro M, Howie D, Morra M, Engel P, Terhorst C (Jun 2001). "Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP". Blood. 97 (12): 3867–74. doi: 10.1182/blood.V97.12.3867 . PMID 11389028. S2CID 10530544.

[pmid12115647-8] Tangye SG, van de Weerdt BC, Avery DT, Hodgkin PD (Jun 2002). "CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2". European Journal of Immunology. 32 (6): 1640–9. doi: 10.1002/1521-4141(200206)32:6<1640::AID-IMMU1640>3.0.CO;2-S . PMID 12115647.

[pmid11477068-9] Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, Sumegi J, Engel P, Li SC, Terhorst C (Sep 2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients" (PDF). The Journal of Biological Chemistry. 276 (39): 36809–16. doi: 10.1074/jbc.M101305200 . PMID 11477068. S2CID 39889619.

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v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

CD84

Contents

Function

Interactions

See also

References

Further reading

External links