IGSF8

IGSF8
Identifiers
Aliases	IGSF8 , CD316, CD81P3, EWI-2, EWI2, KCT-4, LIR-D1, PGRL, immunoglobulin superfamily member 8
External IDs	OMIM: 606644; MGI: 2154090; HomoloGene: 14163; GeneCards: IGSF8; OMA:IGSF8 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	160,098,943 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	172,147,408 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right frontal lobe; ; Brodmann area 9; ; C1 segment; ; prefrontal cortex; ; cingulate gyrus; ; anterior cingulate cortex; ; putamen; ; hypothalamus; ; nucleus accumbens;
	Top expressed in
	ventricular zone; ; primary visual cortex; ; superior frontal gyrus; ; dorsomedial hypothalamic nucleus; ; dentate gyrus of hippocampal formation granule cell; ; subiculum; ; perirhinal cortex; ; superior colliculus; ; respiratory epithelium; ; nasal epithelium;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ;
Cellular component	extracellular exosome ; membrane ; integral component of membrane ; plasma membrane ;
Biological process	skeletal muscle tissue development ; nervous system development ; cell population proliferation ; single fertilization ; cell motility ;
	Sources:Amigo / QuickGO
Orthologs
	93185
	140559
	ENSG00000162729
	ENSMUSG00000038034
	Q969P0
	Q8R366
	NM_001206665 ; NM_052868 ; NM_001320247
	NM_080419
	NP_001193594 ; NP_001307176 ; NP_443100
	NP_536344
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 24, 2024

Immunoglobulin superfamily member 8 is a protein that in humans is encoded by the IGSF8 gene.^[5]^[6]^[7] IGSF8 has also been designated as CD316 (cluster of differentiation 316). IGSF8 is an innate immune checkpoint that inhibits the cytotoxic activity of natural killer (NK) cells.^[8] IGSF8 acts by binding to the Killer Ig-like Receptor KIR3DL2 (or, in mice, the analogous Klra9 receptor).^[8] IGSF8 is frequently overexpressed relative to normal tissues in many cancers, included melanoma, urothelial carcinoma, and breast cancer,^[8] and has been proposed as a potential therapeutic target in gliomas.^[9] In normal tissues, IGSF8 is highly expressed in the brain, where it may contribute to the immune privilege of the central nervous system.^[8]

IGSF8 as a Cancer Biomarker

In gliomas, IGSF8 is strongly correlated with tumor grade and is a potential prognostic marker.^[9] IGSF8 is enriched on ovarian cancer-derived extracellular vesicles and is a potential biomarker for the early detection of high grade serous ovarian cancer.^[10]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000162729 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038034 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Stipp CS, Kolesnikova TV, Hemler ME (Oct 2001). "EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily". J Biol Chem. 276 (44): 40545–54. doi: 10.1074/jbc.M107338200 . PMID 11504738.
↑ Clark KL, Zeng Z, Langford AL, Bowen SM, Todd SC (Oct 2001). "PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins". J Immunol. 167 (9): 5115–21. doi: 10.4049/jimmunol.167.9.5115 . PMID 11673522.
↑ "Entrez Gene: IGSF8 immunoglobulin superfamily, member 8".
1 2 3 4 Li, Yulong; Wu, Xiangyang; Sheng, Caibin; Liu, Hailing; Liu, Huizhu; Tang, Yixuan; Liu, Chao; Ding, Qingyang; Xie, Bin; Xiao, Xi; Zheng, Rongbin; Yu, Quan; Guo, Zengdan; Ma, Jian; Wang, Jin (May 2024). "IGSF8 is an innate immune checkpoint and cancer immunotherapy target". Cell. 187 (11): 2703–2716.e23. doi:10.1016/j.cell.2024.03.039. ISSN 0092-8674. PMID 38657602.
1 2 Ren, Jiaxing; Huang, Ping; Wang, Fei (September 2024). "IGSF8 is a potential target for the treatment of gliomas". Asian Journal of Surgery. 47 (9): 3883–3891. doi:10.1016/j.asjsur.2024.02.118.
↑ Trinidad, Camille V.; Pathak, Harsh B.; Cheng, Shibo; Tzeng, Shin-Cheng; Madan, Rashna; Sardiu, Mihaela E.; Bantis, Leonidas E.; Deighan, Clayton; Jewell, Andrea; Rayamajhi, Sagar; Zeng, Yong; Godwin, Andrew K. (2023-10-26). "Lineage specific extracellular vesicle-associated protein biomarkers for the early detection of high grade serous ovarian cancer". Scientific Reports. 13 (1): 18341. Bibcode:2023NatSR..1318341T. doi:10.1038/s41598-023-44050-5. ISSN 2045-2322. PMC 10603107 . PMID 37884576.

External links

IGSF8+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000162729 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038034 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11504738-5] Stipp CS, Kolesnikova TV, Hemler ME (Oct 2001). "EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily". J Biol Chem. 276 (44): 40545–54. doi: 10.1074/jbc.M107338200 . PMID 11504738.

[pmid11673522-6] Clark KL, Zeng Z, Langford AL, Bowen SM, Todd SC (Oct 2001). "PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins". J Immunol. 167 (9): 5115–21. doi: 10.4049/jimmunol.167.9.5115 . PMID 11673522.

[entrez-7] "Entrez Gene: IGSF8 immunoglobulin superfamily, member 8".

[:0-8] 1 2 3 4 Li, Yulong; Wu, Xiangyang; Sheng, Caibin; Liu, Hailing; Liu, Huizhu; Tang, Yixuan; Liu, Chao; Ding, Qingyang; Xie, Bin; Xiao, Xi; Zheng, Rongbin; Yu, Quan; Guo, Zengdan; Ma, Jian; Wang, Jin (May 2024). "IGSF8 is an innate immune checkpoint and cancer immunotherapy target". Cell. 187 (11): 2703–2716.e23. doi:10.1016/j.cell.2024.03.039. ISSN 0092-8674. PMID 38657602.

[:1-9] 1 2 Ren, Jiaxing; Huang, Ping; Wang, Fei (September 2024). "IGSF8 is a potential target for the treatment of gliomas". Asian Journal of Surgery. 47 (9): 3883–3891. doi:10.1016/j.asjsur.2024.02.118.

[10] Trinidad, Camille V.; Pathak, Harsh B.; Cheng, Shibo; Tzeng, Shin-Cheng; Madan, Rashna; Sardiu, Mihaela E.; Bantis, Leonidas E.; Deighan, Clayton; Jewell, Andrea; Rayamajhi, Sagar; Zeng, Yong; Godwin, Andrew K. (2023-10-26). "Lineage specific extracellular vesicle-associated protein biomarkers for the early detection of high grade serous ovarian cancer". Scientific Reports. 13 (1): 18341. Bibcode:2023NatSR..1318341T. doi:10.1038/s41598-023-44050-5. ISSN 2045-2322. PMC 10603107 . PMID 37884576.

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v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

IGSF8

Contents

IGSF8 as a Cancer Biomarker

Related Research Articles

References

Further reading

External links