IGSF8

IGSF8
Identifiers
Aliases	IGSF8 , CD316, CD81P3, EWI-2, EWI2, KCT-4, LIR-D1, PGRL, immunoglobulin superfamily member 8
External IDs	OMIM: 606644; MGI: 2154090; HomoloGene: 14163; GeneCards: IGSF8; OMA:IGSF8 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q23.2 Start 160,091,340 bp [1] End 160,098,943 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1 H3|1 79.59 cM Start 172,089,208 bp [2] End 172,147,408 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right frontal lobe Brodmann area 9 C1 segment prefrontal cortex cingulate gyrus anterior cingulate cortex putamen hypothalamus nucleus accumbens Top expressed in ventricular zone primary visual cortex superior frontal gyrus dorsomedial hypothalamic nucleus dentate gyrus of hippocampal formation granule cell subiculum perirhinal cortex superior colliculus respiratory epithelium nasal epithelium More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component extracellular exosome membrane integral component of membrane plasma membrane Biological process skeletal muscle tissue development nervous system development cell population proliferation single fertilization cell motility Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 93185 140559 Ensembl ENSG00000162729 ENSMUSG00000038034 UniProt Q969P0 Q8R366 RefSeq (mRNA) NM_001206665 NM_052868 NM_001320247 NM_080419 RefSeq (protein) NP_001193594 NP_001307176 NP_443100 NP_536344 Location (UCSC) Chr 1: 160.09 – 160.1 Mb Chr 1: 172.09 – 172.15 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Immunoglobulin superfamily member 8 is a protein that in humans is encoded by the IGSF8 gene. ^{[5] [6] [7]} IGSF8 has also been designated as CD316 (cluster of differentiation 316). IGSF8 is an innate immune checkpoint that inhibits the cytotoxic activity of natural killer (NK) cells. ^[8] IGSF8 acts by binding to the Killer Ig-like Receptor KIR3DL2 (or, in mice, the analogous Klra9 receptor). ^[8] IGSF8 is frequently overexpressed relative to normal tissues in many cancers, included melanoma, urothelial carcinoma, and breast cancer, ^[8] and has been proposed as a potential therapeutic target in gliomas. ^[9] In normal tissues, IGSF8 is highly expressed in the brain, where it may contribute to the immune privilege of the central nervous system. ^[8]

Cancer biomarker

In gliomas, IGSF8 is strongly correlated with tumor grade and is a potential prognostic marker. ^[9] IGSF8 is enriched on ovarian cancer-derived extracellular vesicles and is a potential biomarker for the early detection of high grade serous ovarian cancer. ^[10]

References

1. GRCh38: Ensembl release 89: ENSG00000162729 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038034 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Stipp CS, Kolesnikova TV, Hemler ME (Oct 2001). "EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily". J Biol Chem. 276 (44): 40545–40554. doi: 10.1074/jbc.M107338200 . PMID   11504738.
6. Clark KL, Zeng Z, Langford AL, Bowen SM, Todd SC (Oct 2001). "PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins". J Immunol. 167 (9): 5115–5121. doi: 10.4049/jimmunol.167.9.5115 . PMID   11673522.
7. "Entrez Gene: IGSF8 immunoglobulin superfamily, member 8".
8. Li Y, Wu X, Sheng C, Liu H, Liu H, Tang Y, et al. (May 2024). "IGSF8 is an innate immune checkpoint and cancer immunotherapy target". Cell. 187 (11): 2703–2716.e23. doi: 10.1016/j.cell.2024.03.039 . ISSN   0092-8674. PMID   38657602.
9. Ren J, Huang P, Wang F (September 2024). "IGSF8 is a potential target for the treatment of gliomas". Asian Journal of Surgery. 47 (9): 3883–3891. doi: 10.1016/j.asjsur.2024.02.118 . PMID   38453613.
10. Trinidad CV, Pathak HB, Cheng S, Tzeng S, Madan R, Sardiu ME, et al. (2023-10-26). "Lineage specific extracellular vesicle-associated protein biomarkers for the early detection of high grade serous ovarian cancer". Scientific Reports. 13 (1) 18341. Bibcode:2023NatSR..1318341T. doi:10.1038/s41598-023-44050-5. ISSN   2045-2322. PMC   10603107 . PMID   37884576.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Charrin S, Le Naour F, Labas V, et al. (2003). "EWI-2 is a new component of the tetraspanin web in hepatocytes and lymphoid cells". Biochem. J. 373 (Pt 2): 409–421. doi:10.1042/BJ20030343. PMC   1223506 . PMID   12708969.
• Zhang XA, Lane WS, Charrin S, et al. (2003). "EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells". Cancer Res. 63 (10): 2665–2674. PMID   12750295.
• Bonkobara M, Das A, Takao J, et al. (2003). "Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes". Br. J. Dermatol. 148 (4): 654–664. doi:10.1046/j.1365-2133.2003.05244.x. PMID   12752121. S2CID   21635573.
• Stipp CS, Kolesnikova TV, Hemler ME (2004). "EWI-2 regulates alpha3beta1 integrin-dependent cell functions on laminin-5". J. Cell Biol. 163 (5): 1167–1177. doi:10.1083/jcb.200309113. PMC   2173626 . PMID   14662754.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi: 10.1038/ng1285 . PMID   14702039.
• Kolesnikova TV, Stipp CS, Rao RM, et al. (2004). "EWI-2 modulates lymphocyte integrin alpha4beta1 functions". Blood. 103 (8): 3013–3019. doi: 10.1182/blood-2003-07-2201 . PMID   15070678.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Yang XH, Kovalenko OV, Kolesnikova TV, et al. (2006). "Contrasting effects of EWI proteins, integrins, and protein palmitoylation on cell surface CD9 organization". J. Biol. Chem. 281 (18): 12976–12985. doi: 10.1074/jbc.M510617200 . PMID   16537545.
• Sala-Valdés M, Ursa A, Charrin S, et al. (2006). "EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins". J. Biol. Chem. 281 (28): 19665–19675. doi: 10.1074/jbc.M602116200 . PMID   16690612.
• Kettner S, Kalthoff F, Graf P, et al. (2007). "EWI-2/CD316 is an inducible receptor of HSPA8 on human dendritic cells". Mol. Cell. Biol. 27 (21): 7718–7726. doi:10.1128/MCB.00180-07. PMC   2169036 . PMID   17785435.

External links

• IGSF8+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)