CD160

CD160
Identifiers
Aliases	CD160 , BY55, NK1, NK28, CD160 molecule
External IDs	OMIM: 604463 MGI: 1860383 HomoloGene: 5122 GeneCards: CD160
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q21.1 Start 145,719,471 bp [1] End 145,739,288 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 F2.1 Start 96,706,079 bp [2] End 96,736,667 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa blood spleen duodenum stromal cell of endometrium bone marrow bone marrow cells monocyte lymph node right coronary artery Top expressed in secondary oocyte morula ascending aorta aortic valve thymus jejunum spleen duodenum blood triceps brachii muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor binding protein binding MHC class I receptor activity signaling receptor activity Cellular component anchored component of membrane anchored component of plasma membrane plasma membrane membrane Biological process cellular defense response cell surface receptor signaling pathway cell population proliferation defense response to Gram-negative bacterium regulation of immune response negative regulation of angiogenesis positive regulation of endothelial cell apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11126 54215 Ensembl ENSG00000117281 ENSMUSG00000038304 UniProt O95971 O88875 RefSeq (mRNA) NM_007053 NM_001163496 NM_001163497 NM_018767 RefSeq (protein) NP_008984 NP_001156968 NP_001156969 NP_061237 Location (UCSC) Chr 1: 145.72 – 145.74 Mb Chr 3: 96.71 – 96.74 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CD160 antigen is a protein that in humans is encoded by the CD160 gene. ^{[5] [6] [7]}

CD160 is a 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules. ^[7]

Clinical significance

CD160 is a ligand for HVEM, and considered a proposed immune checkpoint inhibitor with anti-cancer activity along with anti- PD-1 antibodies. ^[8] CD160 has also been proposed as a potential new target in cases of human pathological ocular and tumor neoangiogenesis that do not respond or become resistant to existing antiangiogenic drugs. ^[9]

Related gene problems

• TAR syndrome ^[10]
• 1q21.1 deletion syndrome
• 1q21.1 duplication syndrome

See also

• Cluster of differentiation

References

1. GRCh38: Ensembl release 89: ENSG00000117281 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038304 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Anumanthan A, Bensussan A, Boumsell L, Christ AD, Blumberg RS, Voss SD, Patel AT, Robertson MJ, Nadler LM, Freeman GJ (Oct 1998). "Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes". J Immunol. 161 (6): 2780–90. doi: 10.4049/jimmunol.161.6.2780 . PMID   9743336. S2CID   25536877.
6. Agrawal S, Marquet J, Freeman GJ, Tawab A, Bouteiller PL, Roth P, Bolton W, Ogg G, Boumsell L, Bensussan A (Apr 1999). "Cutting edge: MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells". J Immunol. 162 (3): 1223–6. doi: 10.4049/jimmunol.162.3.1223 . PMID   9973372. S2CID   23169904.
7. "Entrez Gene: CD160 CD160 molecule".
8. Stecher, Carmen; Battin, Claire; Leitner, Judith; Zettl, Markus; Grabmeier-Pfistershammer, Katharina; H?ller, Christoph; Zlabinger, Gerhard J.; Steinberger, Peter (22 May 2017). "PD-1 Blockade Promotes Emerging Checkpoint Inhibitors in Enhancing T Cell Responses to Allogeneic Dendritic Cells". Frontiers in Immunology. 8: 572. doi: 10.3389/fimmu.2017.00572 . PMC   5439058 . PMID   28588576.
9. Chabot, Sophie; Jabrane-Ferrat, Nabila; Bigot, Karine; Tabiasco, Julie; Provost, Alexandra; Golzio, Muriel; Noman, Muhammad Zaeem; Giustiniani, J?r?me; Bellard, Elisabeth; Brayer, St?phanie; Aguerre-Girr, Maryse; Meggetto, Fabienne; Giuriato, Sylvie; Malecaze, Fran?ois; Galiacy, St?phane; Ja?s, Jean-Philippe; Chose, Olivier; Kadouche, Jean; Chouaib, Salem; Teissi?, Justin; Abitbol, Marc; Bensussan, Armand; Le Bouteiller, Philippe (9 May 2011). "A novel antiangiogenic and vascular normalization therapy targeted against human CD160 receptor". The Journal of Experimental Medicine. 208 (5): 973–986. doi:10.1084/jem.20100810. PMC   3092350 . PMID   21482699.
10. Klopocki E, Schulze H, Strauss G, et al. (February 2007). "Complex inheritance pattern resembling autosomal recessive inheritance involving a microdeletion in thrombocytopenia-absent radius syndrome". Am. J. Hum. Genet. 80 (2): 232–40. doi:10.1086/510919. PMC   1785342 . PMID   17236129.

Further reading

• Bensussan A, Gluckman E, el Marsafy S, et al. (1994). "BY55 monoclonal antibody delineates within human cord blood and bone marrow lymphocytes distinct cell subsets mediating cytotoxic activity". Proc. Natl. Acad. Sci. U.S.A. 91 (19): 9136–40. Bibcode:1994PNAS...91.9136B. doi: 10.1073/pnas.91.19.9136 . PMC   44762 . PMID   8090781.
• Nikolova M, Marie-Cardine A, Boumsell L, Bensussan A (2002). "BY55/CD160 acts as a co-receptor in TCR signal transduction of a human circulating cytotoxic effector T lymphocyte subset lacking CD28 expression". Int. Immunol. 14 (5): 445–51. doi: 10.1093/intimm/14.5.445 . PMID   11978774.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Tanaka J, Toubai T, Tsutsumi Y, et al. (2004). "Cytolytic activity and regulatory functions of inhibitory NK cell receptor-expressing T cells expanded from granulocyte colony-stimulating factor-mobilized peripheral blood mononuclear cells". Blood. 104 (3): 768–74. doi: 10.1182/blood-2003-11-3870 . PMID   15073036.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Barakonyi A, Rabot M, Marie-Cardine A, et al. (2004). "Cutting edge: engagement of CD160 by its HLA-C physiological ligand triggers a unique cytokine profile secretion in the cytotoxic peripheral blood NK cell subset". J. Immunol. 173 (9): 5349–54. doi: 10.4049/jimmunol.173.9.5349 . PMID   15494480.
• Abecassis S, Giustiniani J, Meyer N, et al. (2007). "Identification of a novel CD160+ CD4+ T-lymphocyte subset in the skin: a possible role for CD160 in skin inflammation". J. Invest. Dermatol. 127 (5): 1161–6. doi: 10.1038/sj.jid.5700680 . PMID   17218942.
• Giustiniani J, Marie-Cardine A, Bensussan A (2007). "A soluble form of the MHC class I-specific CD160 receptor is released from human activated NK lymphocytes and inhibits cell-mediated cytotoxicity". J. Immunol. 178 (3): 1293–300. doi: 10.4049/jimmunol.178.3.1293 . PMID   17237375.

External links

• CD160+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human CD160 genome location and CD160 gene details page in the UCSC Genome Browser .