PTGFRN

PTGFRN
Identifiers
Aliases	PTGFRN , CD315, CD9P-1, EWI-F, FPRP, SMAP-6, prostaglandin F2 receptor inhibitor
External IDs	OMIM: 601204; MGI: 1277114; HomoloGene: 7908; GeneCards: PTGFRN; OMA:PTGFRN - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p13.1 Start 116,909,916 bp [1] End 116,990,353 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 F2.2 Start 100,947,548 bp [2] End 101,017,594 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cardiac muscle tissue of right atrium ventricular zone muscle layer of sigmoid colon myocardium of left ventricle right auricle of heart left uterine tube body of uterus olfactory zone of nasal mucosa myometrium right ventricle Top expressed in umbilical cord atrium ventricular zone left lung lobe right lung lobe Gonadal ridge atrioventricular valve molar urinary bladder endocardial cushion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cell surface Golgi apparatus endoplasmic reticulum membrane endoplasmic reticulum membrane plasma membrane integral component of membrane Biological process lipid droplet organization myoblast fusion involved in skeletal muscle regeneration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5738 19221 Ensembl ENSG00000134247 ENSMUSG00000027864 UniProt Q9P2B2 Q9WV91 RefSeq (mRNA) NM_020440 NM_011197 RefSeq (protein) NP_065173 NP_035327 Location (UCSC) Chr 1: 116.91 – 116.99 Mb Chr 3: 100.95 – 101.02 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Prostaglandin F2 receptor negative regulator is a protein that in humans is encoded by the PTGFRN gene. ^{[5] [6]} PTGFRN has also been designated as CD315 (cluster of differentiation 315).

Interactions

PTGFRN has been shown to interact with CD9 ^{[7] [8]} and CD81. ^{[7] [8]}

References

1. GRCh38: Ensembl release 89: ENSG00000134247 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027864 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Orlicky DJ, Berry R, Sikela JM (Jul 1996). "Human chromosome 1 localization of the gene for a prostaglandin F2alpha receptor negative regulatory protein". Hum Genet. 97 (5): 655–8. doi:10.1007/BF02281878. PMID   8655148. S2CID   21645802.
6. "Entrez Gene: PTGFRN prostaglandin F2 receptor negative regulator".
7. Charrin, S; Le Naour F; Oualid M; Billard M; Faure G; Hanash S M; Boucheix C; Rubinstein E (Apr 2001). "The major CD9 and CD81 molecular partner. Identification and characterization of the complexes". J. Biol. Chem. 276 (17). United States: 14329–37. doi: 10.1074/jbc.M011297200 . ISSN   0021-9258. PMID   11278880.
8. Stipp, C S; Orlicky D; Hemler M E (Feb 2001). "FPRP, a major, highly stoichiometric, highly specific CD81- and CD9-associated protein". J. Biol. Chem. 276 (7). United States: 4853–62. doi: 10.1074/jbc.M009859200 . ISSN   0021-9258. PMID   11087758.

Further reading

• Orlicky DJ (1997). "Negative regulatory activity of a prostaglandin F2 alpha receptor associated protein (FPRP)". Prostaglandins Leukot. Essent. Fatty Acids. 54 (4): 247–59. doi:10.1016/S0952-3278(96)90055-1. PMID   8804121.
• Orlicky DJ, Lieber JG, Morin CL, Evans RM (1998). "Synthesis and accumulation of a receptor regulatory protein associated with lipid droplet accumulation in 3T3-L1 cells". J. Lipid Res. 39 (6): 1152–61. doi: 10.1016/S0022-2275(20)32539-6 . PMID   9643346.
• Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi: 10.1093/dnares/7.1.65 . PMID   10718198.
• Stipp CS, Orlicky D, Hemler ME (2001). "FPRP, a major, highly stoichiometric, highly specific CD81- and CD9-associated protein". J. Biol. Chem. 276 (7): 4853–62. doi: 10.1074/jbc.M009859200 . PMID   11087758.
• Charrin S, Le Naour F, Oualid M, et al. (2001). "The major CD9 and CD81 molecular partner. Identification and characterization of the complexes". J. Biol. Chem. 276 (17): 14329–37. doi: 10.1074/jbc.M011297200 . PMID   11278880.
• Clark KL, Zeng Z, Langford AL, et al. (2001). "PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins". J. Immunol. 167 (9): 5115–21. doi: 10.4049/jimmunol.167.9.5115 . PMID   11673522.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• Yang XH, Kovalenko OV, Kolesnikova TV, et al. (2006). "Contrasting effects of EWI proteins, integrins, and protein palmitoylation on cell surface CD9 organization". J. Biol. Chem. 281 (18): 12976–85. doi: 10.1074/jbc.M510617200 . PMID   16537545.
• Sala-Valdés M, Ursa A, Charrin S, et al. (2006). "EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins". J. Biol. Chem. 281 (28): 19665–75. doi: 10.1074/jbc.M602116200 . PMID   16690612.

External links

• PTGFRN+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)