CDCP1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | CDCP1 , CD318, SIMA135, TRASK, CUB domain containing protein 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 611735; MGI: 2442010; HomoloGene: 11276; GeneCards: CDCP1; OMA:CDCP1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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CUB domain-containing protein 1 (CDCP1) is a protein that in humans is encoded by the CDCP1 gene. [5] [6] CDCP1 has also been designated as CD318 (cluster of differentiation 318) and Trask (Transmembrane and associated with src kinases). Alternatively spliced transcript variants encoding distinct isoforms have been reported. [6]
CDCP1 is a 140 kD transmembrane glycoprotein with a large extracellular domain (ECD) containing two CUB domains, and a smaller intracellular domain (ICD). CDCP1 is cleaved by serine proteases at the extracellular domain next to Arg368 to generate a truncated molecule of 80 kDa size. [7] Different cell lines express different amounts of p140 and p80, depending on the activity of endogenous serine proteases.
The intracellular domain of CDCP1 contains five tyrosine residues - Y707, Y734, Y743, Y762 and Y806. The tyrosine phosphorylation of CDCP1 in cultured cells occurs when cells are induced to detach by trypsin or EDTA, or seen spontaneously during mitotic detachment.
The phosphorylation of CDCP1 is seen in many cancers, including some pre-invasive cancers as well as in invasive tumors and in tumor metastases. [8]
Tyrosine-protein kinase ABL1 also known as ABL1 is a protein that, in humans, is encoded by the ABL1 gene located on chromosome 9. c-Abl is sometimes used to refer to the version of the gene found within the mammalian genome, while v-Abl refers to the viral gene, which was initially isolated from the Abelson murine leukemia virus.
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Crk-like protein is a protein that in humans is encoded by the CRKL gene.
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Discoidin, CUB and LCCL domain-containing protein 2 is a protein that in humans is encoded by the DCBLD2 gene.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.