CD98

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solute carrier family 3 member 2 (activators of dibasic and neutral amino acid transport)
Identifiers
Symbol SLC3A2
Alt. symbolsMDU1, 4T2HC, 4F2, NACAE, CD98
NCBI gene 6520
HGNC 11026
OMIM 158070
RefSeq NM_001013251
UniProt P08195
Other data
Locus Chr. 11 q12-q22
Search for
Structures Swiss-model
Domains InterPro
solute carrier family 7 member 5 (cationic amino acid transporter, y+ system)
Identifiers
Symbol SLC7A5
Alt. symbolsLAT1, E16, D16S469E, MPE16, CD98
NCBI gene 8140
HGNC 11063
OMIM 600182
RefSeq NM_003486
UniProt Q01650
Other data
Locus Chr. 16 q24.3
Search for
Structures Swiss-model
Domains InterPro

CD98 is a glycoprotein [1] [2] that is a heterodimer composed of SLC3A2 and SLC7A5 that forms the large neutral amino acid transporter (LAT1). LAT1 is a heterodimeric membrane transport protein that preferentially transports branched-chain (valine, leucine, isoleucine) and aromatic (tryptophan, tyrosine, phenylalanine) amino acids. [3] LAT is highly expressed in brain capillaries (which form the blood–brain barrier) relative to other tissues. [3]

Contents

A functional LAT1 transporter is composed of two proteins encoded by two distinct genes:

See also

References

  1. ↑ Kucharzik T, Lugering A, Yan Y, Driss A, Charrier L, Sitaraman S, Merlin D (2005). "Activation of epithelial CD98 glycoprotein perpetuates colonic inflammation". Lab. Invest. 85 (7): 932–41. doi: 10.1038/labinvest.3700289 . PMID   15880135. S2CID   19733993.
  2. ↑ Lemaître G, Gonnet F, Vaigot P, Gidrol X, Martin MT, Tortajada J, Waksman G (2005). "CD98, a novel marker of transient amplifying human keratinocytes". Proteomics. 5 (14): 3637–45. doi:10.1002/pmic.200401224. PMID   16097038. S2CID   31954787.
  3. 1 2 Boado RJ, Li JY, Nagaya M, Zhang C, Pardridge WM (1999). "Selective expression of the large neutral amino acid transporter at the blood–brain barrier". Proc. Natl. Acad. Sci. U.S.A. 96 (21): 12079–84. Bibcode:1999PNAS...9612079B. doi: 10.1073/pnas.96.21.12079 . PMC   18415 . PMID   10518579.
  4. ↑ Palacin M, Kanai Y (2004). "The ancillary proteins of HATs: SLC3 family of amino acid transporters". Pflügers Arch. 447 (5): 490–494. doi:10.1007/s00424-003-1062-7. PMID   14770309. S2CID   25808108.
  5. ↑ Verrey F, Closs EI, Wagner CA, Palacin M, Endou H, Kanai Y (2004). "CATs and HATs: the SLC7 family of amino acid transporters" (PDF). Pflügers Arch. 447 (5): 532–542. doi:10.1007/s00424-003-1086-z. PMID   14770310. S2CID   11670040.


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