SLC22A11

SLC22A11
Identifiers
Aliases	SLC22A11 , OAT4, hOAT4, solute carrier family 22 member 11
External IDs	OMIM: 607097 HomoloGene: 81863 GeneCards: SLC22A11
Gene location (Human)
Chr.	Chromosome 11 (human)
End	64,572,875 bp
RNA expression pattern
	Top expressed in
	kidney; ; placenta; ; kidney tubule; ; metanephric glomerulus; ; corpus epididymis; ; caput epididymis; ; renal medulla; ; liver; ; right lobe of liver; ; sural nerve;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	organic anion transmembrane transporter activity ; protein binding ; inorganic anion exchanger activity ; transmembrane transporter activity ; sodium-independent organic anion transmembrane transporter activity ; urate transmembrane transporter activity ;
Cellular component	integral component of membrane ; plasma membrane ; integral component of plasma membrane ; extracellular exosome ; apical plasma membrane ; external side of plasma membrane ; membrane ;
Biological process	sodium-independent organic anion transport ; ion transport ; urate metabolic process ; organic anion transport ; transmembrane transport ; inorganic anion transport ; urate transport ; organic acid transmembrane transport ; transport ;
	Sources:Amigo / QuickGO
Orthologs
	55867
	n/a
	ENSG00000168065
	n/a
	Q9NSA0
	n/a
	NM_001307985 ; NM_018484
	n/a
	NP_001294914 ; NP_060954
	n/a
	Wikidata
View/Edit Human

Last updated March 04, 2023

Solute carrier family 22 member 11 is a protein that in humans is encoded by the SLC22A11 gene.^[3]^[4]^[5]^[6]

The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the fetus.^[6]

Related Research Articles

Multidrug resistance-associated protein 2 (MRP2) also called canalicular multispecific organic anion transporter 1 (cMOAT) or ATP-binding cassette sub-family C member 2 (ABCC2) is a protein that in humans is encoded by the ABCC2 gene.

Solute carrier family 22 member 2 is a protein that in humans is encoded by the SLC22A2 gene.

Equilibrative nucleoside transporter 2 (ENT2) is a protein that in humans is encoded by the SLC29A2 gene.

Solute carrier family 22 member 3 (SLC22A3) also known as the organic cation transporter 3 (OCT3) or extraneuronal monoamine transporter (EMT) is a protein that in humans is encoded by the SLC22A3 gene.

Concentrative nucleoside transporter 2 (CNT2) is a protein that in humans is encoded by the SLC28A2 gene.

Solute carrier family 26 member 6 is a protein that in humans is encoded by the SLC26A6 gene. It is an anion-exchanger expressed in the apical membrane of the kidney proximal tubule, the apical membranes of the duct cells in the pancreas, and the villi of the duodenum.

Solute carrier family 22 member 8, or organic anion transporter 3 (OAT3), is a protein that in humans is encoded by the SLC22A8 gene.

Solute carrier family 22, member 12, also known as SLC22A12 and URAT1, is a protein which in humans is encoded by the SLC22A12 gene.

Solute carrier organic anion transporter family member 1B3 (SLCO1B3) also known as organic anion-transporting polypeptide 1B3 (OATP1B3) is a protein that in humans is encoded by the SLCO1B3 gene.

Solute carrier organic anion transporter family member 1A2 is a protein that in humans is encoded by the SLCO1A2 gene.

Multidrug and toxin extrusion protein 1 (MATE1), also known as solute carrier family 47 member 1, is a protein that in humans is encoded by the SLC47A1 gene. SLC47A1 belongs to the MATE family of transporters that are found in bacteria, archaea and eukaryotes.

Solute carrier family 15, member 2, also known as SLC15A2, is a human gene.

Solute carrier organic anion transporter family member 2B1 also known as organic anion-transporting polypeptide 2B1 (OATP2B1) is a protein that in humans is encoded by the gene SLCO2B1.

Solute carrier family 22 member 7 is a protein that in humans is encoded by the gene SLC22A7.

Solute carrier family 22 member 9 is a protein that in humans is encoded by the SLC22A9 gene.

Solute carrier organic anion transporter family member 3A1 is a protein that in humans is encoded by the SLCO3A1 gene.

The organic anion transporter 1 (OAT1) also known as solute carrier family 22 member 6 (SLC22A6) is a protein that in humans is encoded by the SLC22A6 gene. It is a member of the organic anion transporter (OAT) family of proteins. OAT1 is a transmembrane protein that is expressed in the brain, the placenta, the eyes, smooth muscles, and the basolateral membrane of proximal tubular cells of the kidneys. It plays a central role in renal organic anion transport. Along with OAT3, OAT1 mediates the uptake of a wide range of relatively small and hydrophilic organic anions from plasma into the cytoplasm of the proximal tubular cells of the kidneys. From there, these substrates are transported into the lumen of the nephrons of the kidneys for excretion. OAT1 homologs have been identified in rats, mice, rabbits, pigs, flounders, and nematodes.

Monocarboxylate transporter 10, also known as aromatic amino acid transporter 1 and T-type amino acid transporter 1 (TAT1) and solute carrier family 16 member 10 (SLC16A10), is a protein that in humans is encoded by the SLC16A10 gene. SLC16A10 is a member of the solute carrier family.

Solute carrier family 17, member 3 is a protein that in humans is encoded by the SLC17A3 gene.

Solute carrier family 22 member 13 is a protein that in humans is encoded by the SLC22A13 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000168065 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Cha SH, Sekine T, Kusuhara H, Yu E, Kim JY, Kim DK, Sugiyama Y, Kanai Y, Endou H (Mar 2000). "Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta". J Biol Chem. 275 (6): 4507–12. doi: 10.1074/jbc.275.6.4507 . PMID 10660625.
↑ Zhou F, Xu W, Hong M, Pan Z, Sinko PJ, Ma J, You G (Feb 2005). "The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4". Mol Pharmacol. 67 (3): 868–76. doi:10.1124/mol.104.007583. PMID 15576633. S2CID 7477352.
↑ Hagos Y, Stein D, Ugele B, Burckhardt G, Bahn A (Jan 2007). "Human renal organic anion transporter 4 operates as an asymmetric urate transporter". J Am Soc Nephrol. 18 (2): 430–9. doi: 10.1681/ASN.2006040415 . PMID 17229912.
1 2 "Entrez Gene: SLC22A11 solute carrier family 22 (organic anion/cation transporter), member 11".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Sun W, Wu RR, van Poelje PD, Erion MD (2001). "Isolation of a family of organic anion transporters from human liver and kidney". Biochem. Biophys. Res. Commun. 283 (2): 417–22. doi:10.1006/bbrc.2001.4774. PMID 11327718.
Babu E, Takeda M, Narikawa S, et al. (2002). "Human organic anion transporters mediate the transport of tetracycline". Jpn. J. Pharmacol. 88 (1): 69–76. doi: 10.1254/jjp.88.69 . PMID 11855680.
Kimura H, Takeda M, Narikawa S, et al. (2002). "Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins". J. Pharmacol. Exp. Ther. 301 (1): 293–8. doi:10.1124/jpet.301.1.293. PMID 11907186. S2CID 7739298.
Takeda M, Babu E, Narikawa S, Endou H (2002). "Interaction of human organic anion transporters with various cephalosporin antibiotics". Eur. J. Pharmacol. 438 (3): 137–42. doi:10.1016/S0014-2999(02)01306-7. PMID 11909604.
Enomoto A, Takeda M, Shimoda M, et al. (2002). "Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors". J. Pharmacol. Exp. Ther. 301 (3): 797–802. doi:10.1124/jpet.301.3.797. PMID 12023506.
Enomoto A, Kimura H, Chairoungdua A, et al. (2002). "Molecular identification of a renal urate anion exchanger that regulates blood urate levels". Nature. 417 (6887): 447–52. Bibcode:2002Natur.417..447E. doi:10.1038/nature742. PMID 12024214. S2CID 4417844.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Zhou F, Tanaka K, Pan Z, et al. (2004). "The role of glycine residues in the function of human organic anion transporter 4". Mol. Pharmacol. 65 (5): 1141–7. doi:10.1124/mol.65.5.1141. PMID 15102942.
Zhou F, Pan Z, Ma J, You G (2005). "Mutational analysis of histidine residues in human organic anion transporter 4 (hOAT4)". Biochem. J. 384 (Pt 1): 87–92. doi:10.1042/BJ20040751. PMC 1134091 . PMID 15291761.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Taylor TD, Noguchi H, Totoki Y, et al. (2006). "Human chromosome 11 DNA sequence and analysis including novel gene identification". Nature. 440 (7083): 497–500. Bibcode:2006Natur.440..497T. doi: 10.1038/nature04632 . PMID 16554811.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000168065 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10660625-3] Cha SH, Sekine T, Kusuhara H, Yu E, Kim JY, Kim DK, Sugiyama Y, Kanai Y, Endou H (Mar 2000). "Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta". J Biol Chem. 275 (6): 4507–12. doi: 10.1074/jbc.275.6.4507 . PMID 10660625.

[pmid15576633-4] Zhou F, Xu W, Hong M, Pan Z, Sinko PJ, Ma J, You G (Feb 2005). "The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4". Mol Pharmacol. 67 (3): 868–76. doi:10.1124/mol.104.007583. PMID 15576633. S2CID 7477352.

[pmid17229912-5] Hagos Y, Stein D, Ugele B, Burckhardt G, Bahn A (Jan 2007). "Human renal organic anion transporter 4 operates as an asymmetric urate transporter". J Am Soc Nephrol. 18 (2): 430–9. doi: 10.1681/ASN.2006040415 . PMID 17229912.

[entrez-6] 1 2 "Entrez Gene: SLC22A11 solute carrier family 22 (organic anion/cation transporter), member 11".

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SLC22A11

Contents

See also

Related Research Articles

References

Further reading