SLC22A11

Last updated
SLC22A11
Identifiers
Aliases SLC22A11 , OAT4, hOAT4, solute carrier family 22 member 11
External IDs OMIM: 607097 HomoloGene: 81863 GeneCards: SLC22A11
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001307985
NM_018484

n/a

RefSeq (protein)

NP_001294914
NP_060954

n/a

Location (UCSC) Chr 11: 64.56 – 64.57 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

Solute carrier family 22 member 11 is a protein that in humans is encoded by the SLC22A11 gene. [3] [4] [5] [6]

Contents

The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the fetus. [6]

See also

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<span class="mw-page-title-main">SLC17A3</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 17, member 3 is a protein that in humans is encoded by the SLC17A3 gene.

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000168065 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Cha SH, Sekine T, Kusuhara H, Yu E, Kim JY, Kim DK, Sugiyama Y, Kanai Y, Endou H (Mar 2000). "Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta". J Biol Chem. 275 (6): 4507–12. doi: 10.1074/jbc.275.6.4507 . PMID   10660625.
  4. Zhou F, Xu W, Hong M, Pan Z, Sinko PJ, Ma J, You G (Feb 2005). "The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4". Mol Pharmacol. 67 (3): 868–76. doi:10.1124/mol.104.007583. PMID   15576633. S2CID   7477352.
  5. Hagos Y, Stein D, Ugele B, Burckhardt G, Bahn A (Jan 2007). "Human renal organic anion transporter 4 operates as an asymmetric urate transporter". J Am Soc Nephrol. 18 (2): 430–9. doi: 10.1681/ASN.2006040415 . PMID   17229912.
  6. 1 2 "Entrez Gene: SLC22A11 solute carrier family 22 (organic anion/cation transporter), member 11".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.