SLC2A10

SLC2A10
Identifiers
Aliases	SLC2A10 , ATS, GLUT10, solute carrier family 2 member 10, ATORS
External IDs	OMIM: 606145 MGI: 2156687 HomoloGene: 38551 GeneCards: SLC2A10
Gene location (Human)
Chr.	Chromosome 20 (human)
End	46,736,347 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	165,361,837 bp
RNA expression pattern
	Top expressed in
	tibia; ; bronchial epithelial cell; ; stromal cell of endometrium; ; palpebral conjunctiva; ; right lobe of liver; ; prostate; ; periodontal fiber; ; seminal vesicula; ; minor salivary gland; ; right lobe of thyroid gland;
	Top expressed in
	pyloric antrum; ; Epithelium of stomach; ; ascending aorta; ; aortic valve; ; mucous cell of stomach; ; calvaria; ; secondary oocyte; ; body of femur; ; seminal vesicula; ; trachea;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	glucose transmembrane transporter activity ; carbohydrate:proton symporter activity ; transmembrane transporter activity ; transporter activity ; D-glucose transmembrane transporter activity ;
Cellular component	perinuclear region of cytoplasm ; integral component of membrane ; plasma membrane ; membrane ; endomembrane system ; cytoplasm ; integral component of plasma membrane ;
Biological process	carbohydrate transport ; glucose import ; transmembrane transport ; hexose transmembrane transport ; proton transmembrane transport ; glucose transmembrane transport ;
	Sources:Amigo / QuickGO
Orthologs
	81031
	170441
	ENSG00000197496
	ENSMUSG00000027661
	O95528
	Q8VHD6
	NM_030777
	NM_130451
	NP_110404
	NP_569718
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 05, 2023

Solute carrier family 2, facilitated glucose transporter member 10 is a protein that in humans is encoded by the SLC2A10 gene.^[5]^[6]

Related Research Articles

Glucose transporter 2 (GLUT2) also known as solute carrier family 2, member 2 (SLC2A2) is a transmembrane carrier protein that enables protein facilitated glucose movement across cell membranes. It is the principal transporter for transfer of glucose between liver and blood Unlike GLUT4, it does not rely on insulin for facilitated diffusion.

Zinc transporter 8 (ZNT8) is a protein that in humans is encoded by the SLC30A8 gene. ZNT8 is a zinc transporter related to insulin secretion in humans. Certain alleles of the SLC30A8 gene may increase the risk for developing type 2 diabetes, but a loss-of-function mutation appears to greatly reduce the risk of diabetes.

Glucose transporter 3, also known as solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3) is a protein that in humans is encoded by the SLC2A3 gene. GLUT3 facilitates the transport of glucose across the plasma membranes of mammalian cells. GLUT3 is most known for its specific expression in neurons and has originally been designated as the neuronal GLUT. GLUT3 has been studied in other cell types with specific glucose requirements, including sperm, preimplantation embryos, circulating white blood cells and carcinoma cell lines.

Thiamine transporter 2 (ThTr-2), also known as solute carrier family 19 member 3, is a protein that in humans is encoded by the SLC19A3 gene. SLC19A3 is a thiamine transporter.

Glucose-6-phosphate exchanger SLC37A4, also known as glucose-6-phosphate translocase, is an enzyme that in humans is encoded by the SLC37A4 gene.

Equilibrative nucleoside transporter 2 (ENT2) is a protein that in humans is encoded by the SLC29A2 gene.

Sodium- and chloride-dependent creatine transporter 1 is a protein that in humans is encoded by the SLC6A8 gene.

Urea transporter 1 is a protein that in humans is encoded by the SLC14A1 gene.

Sodium bicarbonate transporter-like protein 11 is a protein that in humans is encoded by the SLC4A11 gene.

Y+L amino acid transporter 1 is a protein that in humans is encoded by the SLC7A7 gene.

Solute carrier family 2, facilitated glucose transporter member 12 is a protein that in humans is encoded by the SLC2A12 gene.

Multidrug and toxin extrusion protein 1 (MATE1), also known as solute carrier family 47 member 1, is a protein that in humans is encoded by the SLC47A1 gene. SLC47A1 belongs to the MATE family of transporters that are found in bacteria, archaea and eukaryotes.

Solute carrier family 2, facilitated glucose transporter member 6 is a protein that in humans is encoded by the SLC2A6 gene.

Vesicular inhibitory amino acid transporter is a protein that in humans is encoded by the SLC32A1 gene.

Solute carrier family 2, facilitated glucose transporter member 9 is a protein that in humans is encoded by the SLC2A9 gene.

Bile acyl-CoA synthetase is an enzyme that in humans is encoded by the SLC27A5 gene.

Solute carrier family 22 member 9 is a protein that in humans is encoded by the SLC22A9 gene.

Solute carrier family 2, facilitated glucose transporter member 7 also known as glucose transporter 7 (GLUT7) is a protein that in humans is encoded by the SLC2A7 gene.

Asc-type amino acid transporter 1 (Asc-1) is a protein that in humans is encoded by the SLC7A10 gene.

Solute carrier family 2, facilitated glucose transporter member 11 (SLC2A11) also known as glucose transporter type 10/11 (GLUT-10/11) is a protein that in humans is encoded by the SLC2A11 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000197496 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027661 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ McVie-Wylie AJ, Lamson DR, Chen YT (Mar 2001). "Molecular cloning of a novel member of the GLUT family of transporters, SLC2a10 (GLUT10), localized on chromosome 20q13.1: a candidate gene for NIDDM susceptibility". Genomics. 72 (1): 113–7. doi:10.1006/geno.2000.6457. PMID 11247674.
1 2 "Entrez Gene: SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10".

Dawson PA, Mychaleckyj JC, Fossey SC, et al. (2001). "Sequence and functional analysis of GLUT10: a glucose transporter in the Type 2 diabetes-linked region of chromosome 20q12-13.1". Mol. Genet. Metab. 74 (1–2): 186–99. doi:10.1006/mgme.2001.3212. PMID 11592815.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Richardson S, Neama G, Phillips T, et al. (2003). "Molecular characterization and partial cDNA cloning of facilitative glucose transporters expressed in human articular chondrocytes; stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation". Osteoarthr. Cartil. 11 (2): 92–101. doi: 10.1053/joca.2002.0858 . PMID 12554125.
Wood IS, Hunter L, Trayhurn P (2003). "Expression of Class III facilitative glucose transporter genes (GLUT-10 and GLUT-12) in mouse and human adipose tissues". Biochem. Biophys. Res. Commun. 308 (1): 43–9. doi:10.1016/S0006-291X(03)01322-6. PMID 12890477.
Andersen G, Rose CS, Hamid YH, et al. (2003). "Genetic variation of the GLUT10 glucose transporter (SLC2A10) and relationships to type 2 diabetes and intermediary traits". Diabetes. 52 (9): 2445–8. doi: 10.2337/diabetes.52.9.2445 . PMID 12941788.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Zaidi SH, Peltekova V, Meyer S, et al. (2005). "A family exhibiting arterial tortuosity syndrome displays homozygosity for markers in the arterial tortuosity locus at chromosome 20q13". Clin. Genet. 67 (2): 183–8. doi:10.1111/j.1399-0004.2004.00391.x. PMID 15679832. S2CID 21973630.
Mohlke KL, Skol AD, Scott LJ, et al. (2005). "Evaluation of SLC2A10 (GLUT10) as a candidate gene for type 2 diabetes and related traits in Finns". Mol. Genet. Metab. 85 (4): 323–7. doi:10.1016/j.ymgme.2005.04.011. PMID 15936967.
Segade F, Allred DC, Bowden DW (2005). "Functional characterization of the promoter of the human glucose transporter 10 gene". Biochim. Biophys. Acta. 1730 (2): 147–58. doi:10.1016/j.bbaexp.2005.06.012. PMID 16051383.
Coucke PJ, Willaert A, Wessels MW, et al. (2006). "Mutations in the facilitative glucose transporter GLUT10 alter angiogenesis and cause arterial tortuosity syndrome" (PDF). Nat. Genet. 38 (4): 452–7. doi:10.1038/ng1764. hdl: 11379/29243 . PMID 16550171. S2CID 836017.
Lin WH, Chuang LM, Chen CH, et al. (2006). "Association study of genetic polymorphisms of SLC2A10 gene and type 2 diabetes in the Taiwanese population". Diabetologia. 49 (6): 1214–21. doi: 10.1007/s00125-006-0218-3 . PMID 16586067.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000197496 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027661 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11247674-5] McVie-Wylie AJ, Lamson DR, Chen YT (Mar 2001). "Molecular cloning of a novel member of the GLUT family of transporters, SLC2a10 (GLUT10), localized on chromosome 20q13.1: a candidate gene for NIDDM susceptibility". Genomics. 72 (1): 113–7. doi:10.1006/geno.2000.6457. PMID 11247674.

[entrez-6] 1 2 "Entrez Gene: SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10".

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SLC2A10

Contents

See also

Related Research Articles

References

Further reading