SLC13A2

SLC13A2
Identifiers
Aliases	SLC13A2 , NADC1, NaCT, NaDC-1, SDCT1, solute carrier family 13 member 2
External IDs	OMIM: 604148 MGI: 1276558 HomoloGene: 2965 GeneCards: SLC13A2
Gene location (Human)
Chr.	Chromosome 17 (human)
End	28,497,781 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	78,313,043 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; duodenum; ; kidney; ; salivary gland; ; minor salivary gland; ; lactiferous duct; ; parotid gland; ; gallbladder; ; rectum; ; trachea;
	Top expressed in
	intestinal villus; ; jejunum; ; left colon; ; proximal tubule; ; ileum; ; kidney; ; conjunctival fornix; ; morula; ; seminal vesicula; ; crypt of lieberkuhn of small intestine;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	low-affinity sodium:dicarboxylate symporter activity ; symporter activity ; transporter activity ;
Cellular component	integral component of membrane ; plasma membrane ; integral component of plasma membrane ; extracellular exosome ; membrane ;
Biological process	ion transport ; sodium ion transport ; dicarboxylic acid transport ; transmembrane transport ; anion transmembrane transport ; transport ;
	Sources:Amigo / QuickGO
Orthologs
	9058
	20500
	ENSG00000007216
	ENSMUSG00000001095
	Q13183
	Q9ES88
	NM_001145975 ; NM_001145976 ; NM_003984 ; NM_001346683 ; NM_001346684
	NM_022411
	NP_001139447 ; NP_001333612 ; NP_001333613 ; NP_003975
	NP_071856
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 05, 2023

Solute carrier family 13 member 2 is a protein that is encoded in humans by the SLC13A2 gene.^[5]^[6]^[7]

Related Research Articles

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The organic anion transporter 1 (OAT1) also known as solute carrier family 22 member 6 (SLC22A6) is a protein that in humans is encoded by the SLC22A6 gene. It is a member of the organic anion transporter (OAT) family of proteins. OAT1 is a transmembrane protein that is expressed in the brain, the placenta, the eyes, smooth muscles, and the basolateral membrane of proximal tubular cells of the kidneys. It plays a central role in renal organic anion transport. Along with OAT3, OAT1 mediates the uptake of a wide range of relatively small and hydrophilic organic anions from plasma into the cytoplasm of the proximal tubular cells of the kidneys. From there, these substrates are transported into the lumen of the nephrons of the kidneys for excretion. OAT1 homologs have been identified in rats, mice, rabbits, pigs, flounders, and nematodes.

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000007216 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001095 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Pajor AM (Dec 1996). "Molecular cloning and functional expression of a sodium-dicarboxylate cotransporter from human kidney". Am J Physiol. 270 (4 Pt 2): F642–8. doi:10.1152/ajprenal.1996.270.4.F642. PMID 8967342.
↑ Mann SS, Hart TC, Pettenati MJ, von Kap-herr C, Holmes RP (Jun 1999). "Assignment of the sodium-dependent dicarboxylate transporter gene (SLC13A2 alias NaDC-1) to human chromosome region 17p11.1→q11.1 by radiation hybrid mapping and fluorescence in situ hybridization". Cytogenet Cell Genet. 84 (1–2): 89–90. doi:10.1159/000015222. PMID 10343111. S2CID 26457719.
↑ "Entrez Gene: SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2".

Inoue K, Zhuang L, Ganapathy V (2003). "Human Na+ -coupled citrate transporter: primary structure, genomic organization, and transport function". Biochem. Biophys. Res. Commun. 299 (3): 465–71. doi:10.1016/S0006-291X(02)02669-4. PMID 12445824.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Bai X, Chen X, Fen Z, et al. (2005). "Expression of EGFP/SDCT1 fusion protein, subcellular localization signal analysis, tissue distribution and electrophysiological function study". Science in China Series C: Life Sciences. 47 (6): 530–9. doi:10.1360/03yc0044. PMID 15620109. S2CID 36487757.
Pajor AM, Randolph KM (2005). "Conformationally sensitive residues in extracellular loop 5 of the Na+/dicarboxylate co-transporter". J. Biol. Chem. 280 (19): 18728–35. doi: 10.1074/jbc.M501265200 . PMC 1224748 . PMID 15774465.
Okamoto N, Aruga S, Matsuzaki S, et al. (2007). "Associations between renal sodium-citrate cotransporter (hNaDC-1) gene polymorphism and urinary citrate excretion in recurrent renal calcium stone formers and normal controls". Int. J. Urol. 14 (4): 344–9. doi: 10.1111/j.1442-2042.2007.01554.x . PMID 17470169. S2CID 41274929.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000007216 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001095 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8967342-5] Pajor AM (Dec 1996). "Molecular cloning and functional expression of a sodium-dicarboxylate cotransporter from human kidney". Am J Physiol. 270 (4 Pt 2): F642–8. doi:10.1152/ajprenal.1996.270.4.F642. PMID 8967342.

[pmid10343111-6] Mann SS, Hart TC, Pettenati MJ, von Kap-herr C, Holmes RP (Jun 1999). "Assignment of the sodium-dependent dicarboxylate transporter gene (SLC13A2 alias NaDC-1) to human chromosome region 17p11.1→q11.1 by radiation hybrid mapping and fluorescence in situ hybridization". Cytogenet Cell Genet. 84 (1–2): 89–90. doi:10.1159/000015222. PMID 10343111. S2CID 26457719.

[entrez-7] "Entrez Gene: SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2".

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SLC13A2

Related Research Articles

References

Further reading