SLC22A7

SLC22A7
Identifiers
Aliases	SLC22A7 , NLT, OAT2, solute carrier family 22 member 7, hOAT11
External IDs	OMIM: 604995; MGI: 1859559; HomoloGene: 21328; GeneCards: SLC22A7; OMA:SLC22A7 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p21.1 Start 43,295,694 bp [1] End 43,305,538 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 C Start 46,743,109 bp [2] End 46,749,383 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver kidney tubule renal medulla vena cava olfactory bulb glomerulus metanephric glomerulus human kidney right testis Skeletal muscle tissue of rectus abdominis Top expressed in right kidney human kidney left lobe of liver proximal tubule embryo embryo morula convoluted tubule proximal convoluted tubule thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function organic anion transmembrane transporter activity protein binding inorganic anion exchanger activity sodium-independent organic anion transmembrane transporter activity Cellular component integral component of membrane plasma membrane basolateral plasma membrane integral component of plasma membrane membrane Biological process ion transport organic anion transport transmembrane transport anion transmembrane transport inorganic anion transport sodium-independent organic anion transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10864 108114 Ensembl ENSG00000137204 ENSMUSG00000067144 UniProt Q9Y694 Q5T051 Q91WU2 RefSeq (mRNA) NM_006672 NM_153320 NM_144856 RefSeq (protein) NP_006663 NP_696961 NP_659105 Location (UCSC) Chr 6: 43.3 – 43.31 Mb Chr 17: 46.74 – 46.75 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Solute carrier family 22 member 7 is a protein that in humans is encoded by the gene SLC22A7. ^{[5] [6] [7]}

The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Alternatively spliced transcript variants encoding different isoforms have been described. ^[7]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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|alt=Fluorouracil (5-FU) Activity edit]]

Fluorouracil (5-FU) Activity edit

1. The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

See also

• SLC22A7+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

References

1. GRCh38: Ensembl release 89: ENSG00000137204 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000067144 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, Endou H (Jul 1998). "Identification of multispecific organic anion transporter 2 expressed predominantly in the liver". FEBS Lett. 429 (2): 179–82. doi: 10.1016/S0014-5793(98)00585-7 . PMID   9650585. S2CID   30015233.
6. Kok LD, Siu SS, Fung KP, Tsui SK, Lee CY, Waye MM (Jun 2000). "Assignment of liver-specific organic anion transporter (SLC22A7) to human chromosome 6 bands p21.2→p21.1 using radiation hybrids". Cytogenet Cell Genet. 88 (1–2): 76–7. doi:10.1159/000015489. PMID   10773670. S2CID   8702529.
7. "Entrez Gene: SLC22A7 solute carrier family 22 (organic anion transporter), member 7".

Further reading

• Cropp CD, Komori T, Shima JE, et al. (2008). "Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP". Mol. Pharmacol. 73 (4): 1151–8. doi:10.1124/mol.107.043117. PMC   2698938 . PMID   18216183.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Enomoto A, Takeda M, Shimoda M, et al. (2002). "Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors". J. Pharmacol. Exp. Ther. 301 (3): 797–802. doi:10.1124/jpet.301.3.797. PMID   12023506.
• Kimura H, Takeda M, Narikawa S, et al. (2002). "Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins". J. Pharmacol. Exp. Ther. 301 (1): 293–8. doi:10.1124/jpet.301.1.293. PMID   11907186. S2CID   7739298.
• Babu E, Takeda M, Narikawa S, et al. (2002). "Human organic anion transporters mediate the transport of tetracycline". Jpn. J. Pharmacol. 88 (1): 69–76. doi: 10.1254/jjp.88.69 . PMID   11855680.
• Sun W, Wu RR, van Poelje PD, Erion MD (2001). "Isolation of a family of organic anion transporters from human liver and kidney". Biochem. Biophys. Res. Commun. 283 (2): 417–22. doi:10.1006/bbrc.2001.4774. PMID   11327718.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.