SLC22A7

Last updated
SLC22A7
Identifiers
Aliases SLC22A7 , NLT, OAT2, solute carrier family 22 member 7, hOAT11
External IDs OMIM: 604995 MGI: 1859559 HomoloGene: 21328 GeneCards: SLC22A7
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006672
NM_153320

NM_144856

RefSeq (protein)

NP_006663
NP_696961

NP_659105

Location (UCSC) Chr 6: 43.3 – 43.31 Mb Chr 17: 46.74 – 46.75 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Solute carrier family 22 member 7 is a protein that in humans is encoded by the gene SLC22A7. [5] [6] [7]

Contents

The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Alternatively spliced transcript variants encoding different isoforms have been described. [7]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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FluoropyrimidineActivity WP1601.png go to articlego to articlego to articlego to pathway articlego to pathway articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to pathway articlego to pathway articlego to articlego to articlego to articlego to articlego to articlego to WikiPathwaysgo to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to article
|alt=Fluorouracil (5-FU) Activity edit]]
Fluorouracil (5-FU) Activity edit
  1. The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

See also

Related Research Articles

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Multidrug resistance-associated protein 2 (MRP2) also called canalicular multispecific organic anion transporter 1 (cMOAT) or ATP-binding cassette sub-family C member 2 (ABCC2) is a protein that in humans is encoded by the ABCC2 gene.

<span class="mw-page-title-main">SLC22A4</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 22, member 4, also known as SLC22A4, is a human gene; the encoded protein is known as the ergothioneine transporter.

<span class="mw-page-title-main">SLC22A2</span> Protein-coding gene

Solute carrier family 22 member 2 is a protein that in humans is encoded by the SLC22A2 gene.

<span class="mw-page-title-main">Solute carrier organic anion transporter family member 1B1</span> Protein-coding gene in the species Homo sapiens

Solute carrier organic anion transporter family member 1B1 is a protein that in humans is encoded by the SLCO1B1 gene. Pharmacogenomic research indicates that genetic variations in this gene are associated with response to simvastatin. Clinical guidelines exist that can guide dosing of simvastatin based on SLCO1B1 gene variant using genotyping or whole exome sequencing.

<span class="mw-page-title-main">Equilibrative nucleoside transporter 2</span> Protein-coding gene in the species Homo sapiens

Equilibrative nucleoside transporter 2 (ENT2) is a protein that in humans is encoded by the SLC29A2 gene.

<span class="mw-page-title-main">SLC22A3</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 22 member 3 (SLC22A3) also known as the organic cation transporter 3 (OCT3) or extraneuronal monoamine transporter (EMT) is a protein that in humans is encoded by the SLC22A3 gene.

<span class="mw-page-title-main">SLC22A11</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 22 member 11 is a protein that in humans is encoded by the SLC22A11 gene.

<span class="mw-page-title-main">Concentrative nucleoside transporter 1</span> The gene that determine size of cells

Concentrative nucleoside transporter 1 (CNT1) is a protein that in humans is encoded by the SLC28A1 gene.

<span class="mw-page-title-main">SLC22A8</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 22 member 8, or organic anion transporter 3 (OAT3), is a protein that in humans is encoded by the SLC22A8 gene.

<span class="mw-page-title-main">SLC22A12</span> Mammalian protein found in Homo sapiens

Solute carrier family 22, member 12, also known as SLC22A12 and URAT1, is a protein which in humans is encoded by the SLC22A12 gene.

<span class="mw-page-title-main">Solute carrier organic anion transporter family member 1B3</span> Protein-coding gene in the species Homo sapiens

Solute carrier organic anion transporter family member 1B3 (SLCO1B3) also known as organic anion-transporting polypeptide 1B3 (OATP1B3) is a protein that in humans is encoded by the SLCO1B3 gene.

<span class="mw-page-title-main">Solute carrier organic anion transporter family member 1A2</span>

Solute carrier organic anion transporter family member 1A2 is a protein that in humans is encoded by the SLCO1A2 gene.

<span class="mw-page-title-main">Multidrug and toxin extrusion protein 1</span> Protein-coding gene in the species Homo sapiens

Multidrug and toxin extrusion protein 1 (MATE1), also known as solute carrier family 47 member 1, is a protein that in humans is encoded by the SLC47A1 gene. SLC47A1 belongs to the MATE family of transporters that are found in bacteria, archaea and eukaryotes.

<span class="mw-page-title-main">Solute carrier organic anion transporter family member 2B1</span> Protein-coding gene in the species Homo sapiens

Solute carrier organic anion transporter family member 2B1 also known as organic anion-transporting polypeptide 2B1 (OATP2B1) is a protein that in humans is encoded by the gene SLCO2B1.

<span class="mw-page-title-main">SLC22A9</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 22 member 9 is a protein that in humans is encoded by the SLC22A9 gene.

<span class="mw-page-title-main">Organic anion transporter 1</span> Protein-coding gene in the species Homo sapiens

The organic anion transporter 1 (OAT1) also known as solute carrier family 22 member 6 (SLC22A6) is a protein that in humans is encoded by the SLC22A6 gene. It is a member of the organic anion transporter (OAT) family of proteins. OAT1 is a transmembrane protein that is expressed in the brain, the placenta, the eyes, smooth muscles, and the basolateral membrane of proximal tubular cells of the kidneys. It plays a central role in renal organic anion transport. Along with OAT3, OAT1 mediates the uptake of a wide range of relatively small and hydrophilic organic anions from plasma into the cytoplasm of the proximal tubular cells of the kidneys. From there, these substrates are transported into the lumen of the nephrons of the kidneys for excretion. OAT1 homologs have been identified in rats, mice, rabbits, pigs, flounders, and nematodes.

<span class="mw-page-title-main">SLC22A25</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 22 member 25 (SLC22A25), also known as organic anion transporter UST6, is a protein that in humans is encoded by the SLC22A25 gene.

<span class="mw-page-title-main">SLC22A10</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 22 member 10 (SLC22A10), also known as organic anion transporter 5 (OAT5), is a protein that in humans is encoded by the SLC22A10 gene.

<span class="mw-page-title-main">SLC17A3</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 17, member 3 is a protein that in humans is encoded by the SLC17A3 gene.

<span class="mw-page-title-main">SLC22A13</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 22 member 13 is a protein that in humans is encoded by the SLC22A13 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000137204 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000067144 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, Endou H (Jul 1998). "Identification of multispecific organic anion transporter 2 expressed predominantly in the liver". FEBS Lett. 429 (2): 179–82. doi:10.1016/S0014-5793(98)00585-7. PMID   9650585. S2CID   30015233.
  6. Kok LD, Siu SS, Fung KP, Tsui SK, Lee CY, Waye MM (Jun 2000). "Assignment of liver-specific organic anion transporter (SLC22A7) to human chromosome 6 bands p21.2→p21.1 using radiation hybrids". Cytogenet Cell Genet. 88 (1–2): 76–7. doi:10.1159/000015489. PMID   10773670. S2CID   8702529.
  7. 1 2 "Entrez Gene: SLC22A7 solute carrier family 22 (organic anion transporter), member 7".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.