SLC2A7

SLC2A7
Identifiers
Aliases	SLC2A7 , GLUT7, solute carrier family 2 member 7, GLUT-7, hGLUT7
External IDs	OMIM: 610371; MGI: 3650865; HomoloGene: 72470; GeneCards: SLC2A7; OMA:SLC2A7 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p36.23 Start 9,002,973 bp [1] End 9,026,423 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4 E2|4 Start 150,233,429 bp [2] End 150,252,939 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in duodenum colon smooth muscle tissue Top expressed in jejunum duodenum blastocyst yolk sac embryo embryo colon ileum placenta spleen More reference expression data BioGPS n/a
Gene ontology Molecular function transporter activity transmembrane transporter activity sugar transmembrane transporter activity Cellular component plasma membrane membrane integral component of membrane Biological process carbohydrate transport transmembrane transport hexose transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 155184 435818 Ensembl ENSG00000197241 ENSMUSG00000062064 UniProt Q6PXP3 P0C6A1 RefSeq (mRNA) NM_207420 NM_001085529 NM_001368869 RefSeq (protein) NP_997303 NP_001078998 NP_001355798 Location (UCSC) Chr 1: 9 – 9.03 Mb Chr 4: 150.23 – 150.25 Mb PubMed search [3] [4]
Wikidata
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Solute carrier family 2, facilitated glucose transporter member 7 also known as glucose transporter 7 (GLUT7) is a protein that in humans is encoded by the SLC2A7 gene. ^{[5] [6]}

SLC2A7 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion. ^[6] This family of transporters shows conservation of 12 transmembrane helices as well as functionally significant amino acid residues. ^[7]

See also

• Glucose transporter

References

1. GRCh38: Ensembl release 89: ENSG00000197241 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000062064 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: solute carrier family 2 (facilitated glucose transporter)".
6. Li Q, Manolescu A, Ritzel M, Yao S, Slugoski M, Young JD, Chen XZ, Cheeseman CI (July 2004). "Cloning and functional characterization of the human GLUT7 isoform SLC2A7 from the small intestine". Am. J. Physiol. Gastrointest. Liver Physiol. 287 (1): G236–42. doi:10.1152/ajpgi.00396.2003. PMID   15033637. S2CID   21269350.
7. Joost HG, Thorens B (2001). "The extended GLUT-family of sugar/polyol transport facilitators: nomenclature, sequence characteristics, and potential function of its novel members (review)". Mol. Membr. Biol. 18 (4): 247–56. doi: 10.1080/09687680110090456 . PMID   11780753. S2CID   22667943.

Further reading

• Manolescu A, Salas-Burgos AM, Fischbarg J, Cheeseman CI (2005). "Identification of a hydrophobic residue as a key determinant of fructose transport by the facilitative hexose transporter SLC2A7 (GLUT7)". J. Biol. Chem. 280 (52): 42978–83. doi: 10.1074/jbc.M508678200 . PMID   16186102.