| solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 | |
|---|---|
| Identifiers | |
| Symbol | SLC25A15 |
| Alt. symbols | ORNT1, HHH |
| NCBI gene | 10166 |
| HGNC | 10985 |
| OMIM | 603861 |
| RefSeq | NM_014252 |
| UniProt | Q9Y619 |
| Other data | |
| Locus | Chr. 13 q14 |
Ornithine translocase is responsible for transporting ornithine from the cytosol into the mitochondria in the urea cycle. It is highly expressed in Liver and Pancreas
A disorder is associated with ornithine translocase deficiency, and a form of hyperammonemia.
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Ensembl genome database project is a scientific project at the European Bioinformatics Institute, which was launched in 1999 in response to the imminent completion of the Human Genome Project. Ensembl aims to provide a centralized resource for geneticists, molecular biologists and other researchers studying the genomes of our own species and other vertebrates and model organisms. Ensembl is one of several well known genome browsers for the retrieval of genomic information.
Ornithine translocase deficiency, also called hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome, is a rare autosomal recessive urea cycle disorder affecting the enzyme ornithine translocase, which causes ammonia to accumulate in the blood, a condition called hyperammonemia.
Chemokine ligand 26 (CCL26) is a small cytokine belonging to the CC chemokine family that is also called Eotaxin-3, Macrophage inflammatory protein 4-alpha (MIP-4-alpha), Thymic stroma chemokine-1 (TSC-1), and IMAC. It is expressed by several tissues including heart, lung and ovary, and in endothelial cells that have been stimulated with the cytokine interleukin 4. CCL26 is chemotactic for eosinophils and basophils and elicits its effects by binding to the cell surface chemokine receptor CCR3. This gene for chemokine is located on human chromosome 7.
Citrin also known as solute carrier family 25, member 13 (citrin) or SLC25A13 is a protein which in humans is encoded by the SLC25A13 gene.
C-C chemokine receptor type 11 is a protein that in humans is encoded by the CCRL1 gene.
Chemokine-binding protein 2 is a protein that in humans is encoded by the CCBP2 gene.
Cadherin-15 is a protein that in humans is encoded by the CDH15 gene.
Olfactory receptor 56B1 is a protein that in humans is encoded by the OR56B1 gene.
Antizyme inhibitor 2 (AzI2) also known as arginine decarboxylase (ADC) is an enzyme that in humans is encoded by the AZIN2 gene.
Probable ribosome biogenesis protein RLP24 is a protein that in humans is encoded by the RSL24D1 gene.
Antizyme inhibitor 1 is a protein that in humans is encoded by the AZIN1 gene.
Probable phospholipid-transporting ATPase VA also known as ATPase class V type 10A (ATP10A) or aminophospholipid translocase VA is an enzyme that in humans is encoded by the ATP10A gene.
ADP/ATP translocase 4 (ANT4) is an enzyme that in humans is encoded by the SLC25A31 gene on chromosome 4. This enzyme inhibits apoptosis by catalyzing ADP/ATP exchange across the mitochondrial membranes and regulating membrane potential. In particular, ANT4 is essential to spermatogenesis, as it imports ATP into sperm mitochondria to support their development and survival. Outside this role, the SLC25AC31 gene has not been implicated in any human disease.
Eukaryotic translation initiation factor 1b is a protein that in humans is encoded by the EIF1B gene.
ADP/ATP translocase 3, also known as solute carrier family 25 member 6, is a protein that in humans is encoded by the SLC25A6 gene.
The UCSC Genome Browser is an on-line, and downloadable, genome browser hosted by the University of California, Santa Cruz (UCSC). It is an interactive website offering access to genome sequence data from a variety of vertebrate and invertebrate species and major model organisms, integrated with a large collection of aligned annotations. The Browser is a graphical viewer optimized to support fast interactive performance and is an open-source, web-based tool suite built on top of a MySQL database for rapid visualization, examination, and querying of the data at many levels. The Genome Browser Database, browsing tools, downloadable data files, and documentation can all be found on the UCSC Genome Bioinformatics website.
Iroquois-class homeodomain protein IRX-5, also known as Iroquois homeobox protein 5, is a protein that in humans is encoded by the IRX5 gene.
The human gene ATP8B3 encodes the protein ATPase, aminophospholipid transporter, class I, type 8B, member 3.
Solute carrier family 25, member 29 is a protein that in humans is encoded by the SLC25A29 gene. The gene is also known as CACL and C14orf69. SLC25A29 belongs to a protein family of solute carriers called the mitochondrial carriers.
ADP/ATP translocase 2 is a protein that in humans is encoded by the SLC25A5 gene on the X chromosome.