Monocarboxylate transporter 3

Last updated
SLC16A8
Identifiers
Aliases SLC16A8 , MCT3, REMP, solute carrier family 16 member 8
External IDs OMIM: 610409 MGI: 1929519 HomoloGene: 75006 GeneCards: SLC16A8
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_013356
NM_001394131

NM_020516

RefSeq (protein)

NP_037488

NP_065262

Location (UCSC) Chr 22: 38.08 – 38.08 Mb Chr 15: 79.14 – 79.14 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Monocarboxylate transporter 3 (MCT3) also known as solute carrier family 16 member 8 is a protein that in humans is encoded by the SLC16A8 gene. [5] MCT is a proton-coupled monocarboxylate transporter. It catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. It also functions as high-affinity pyruvate transporter.

Contents

Expression of SLC16A8 is confined to the retinal pigment epithelium and choroid plexus epithelia, where it is located on the basal membrane in contrast to MCT1 which is found on the apical membrane.

See also

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000100156 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032988 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Garcia CK, Goldstein JL, Pathak RK, Anderson RG, Brown MS (Mar 1994). "Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle". Cell. 76 (5): 865–73. doi:10.1016/0092-8674(94)90361-1. PMID   8124722. S2CID   22137883.

Further reading