SLC22A9

SLC22A9
Identifiers
Aliases	SLC22A9 , HOAT4, OAT4, OAT7, UST3H, ust3, solute carrier family 22 member 9
External IDs	OMIM: 607579 HomoloGene: 137850 GeneCards: SLC22A9
Gene location (Human)
Chr.	Chromosome 11 (human)
End	63,410,294 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; Brodmann area 9; ; gallbladder; ; prefrontal cortex; ; amygdala; ; islet of Langerhans; ; superior frontal gyrus; ; lymph node; ; putamen; ; hippocampal formation;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	sodium-independent organic anion transmembrane transporter activity ; short-chain fatty acid transmembrane transporter activity ; inorganic anion exchanger activity ; urate transmembrane transporter activity ;
Cellular component	integral component of membrane ; plasma membrane ; basolateral plasma membrane ; integral component of plasma membrane ; membrane ;
Biological process	sodium-independent organic anion transport ; hormone transport ; short-chain fatty acid import ; transmembrane transport ; anion transmembrane transport ; inorganic anion transport ; urate transport ; organic anion transport ;
	Sources:Amigo / QuickGO
Orthologs
	114571
	n/a
	ENSG00000149742
	n/a
	Q8IVM8
	n/a
	NM_080866
	n/a
	NP_543142
	n/a
	Wikidata
View/Edit Human

Last updated March 04, 2023

Solute carrier family 22 member 9 is a protein that in humans is encoded by the SLC22A9 gene.^[3]^[4]^[5]

Related Research Articles

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Solute carrier family 26 member 6 is a protein that in humans is encoded by the SLC26A6 gene. It is an anion-exchanger expressed in the apical membrane of the kidney proximal tubule, the apical membranes of the duct cells in the pancreas, and the villi of the duodenum.

Solute carrier family 22, member 12, also known as SLC22A12 and URAT1, is a protein which in humans is encoded by the SLC22A12 gene.

Solute carrier organic anion transporter family member 1B3 (SLCO1B3) also known as organic anion-transporting polypeptide 1B3 (OATP1B3) is a protein that in humans is encoded by the SLCO1B3 gene.

Solute carrier organic anion transporter family member 1A2 is a protein that in humans is encoded by the SLCO1A2 gene.

Sodium-dependent phosphate transport protein 2B (NaPi2b) is a protein that in humans is encoded by the SLC34A2 gene.

Solute carrier family 2, facilitated glucose transporter member 12 is a protein that in humans is encoded by the SLC2A12 gene.

Multidrug and toxin extrusion protein 1 (MATE1), also known as solute carrier family 47 member 1, is a protein that in humans is encoded by the SLC47A1 gene. SLC47A1 belongs to the MATE family of transporters that are found in bacteria, archaea and eukaryotes.

Urea transporter 2 is a protein that in humans is encoded by the SLC14A2 gene.

Solute carrier organic anion transporter family member 2B1 also known as organic anion-transporting polypeptide 2B1 (OATP2B1) is a protein that in humans is encoded by the gene SLCO2B1.

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Solute carrier organic anion transporter family member 4A1 is a protein that in humans is encoded by the SLCO4A1 gene.

Solute carrier organic anion transporter family member 3A1 is a protein that in humans is encoded by the SLCO3A1 gene.

The organic anion transporter 1 (OAT1) also known as solute carrier family 22 member 6 (SLC22A6) is a protein that in humans is encoded by the SLC22A6 gene. It is a member of the organic anion transporter (OAT) family of proteins. OAT1 is a transmembrane protein that is expressed in the brain, the placenta, the eyes, smooth muscles, and the basolateral membrane of proximal tubular cells of the kidneys. It plays a central role in renal organic anion transport. Along with OAT3, OAT1 mediates the uptake of a wide range of relatively small and hydrophilic organic anions from plasma into the cytoplasm of the proximal tubular cells of the kidneys. From there, these substrates are transported into the lumen of the nephrons of the kidneys for excretion. OAT1 homologs have been identified in rats, mice, rabbits, pigs, flounders, and nematodes.

Solute carrier family 22 member 25 (SLC22A25), also known as organic anion transporter UST6, is a protein that in humans is encoded by the SLC22A25 gene.

Monocarboxylate transporter 10, also known as aromatic amino acid transporter 1 and T-type amino acid transporter 1 (TAT1) and solute carrier family 16 member 10 (SLC16A10), is a protein that in humans is encoded by the SLC16A10 gene. SLC16A10 is a member of the solute carrier family.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000149742 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Sun W, Wu RR, van Poelje PD, Erion MD (Apr 2001). "Isolation of a family of organic anion transporters from human liver and kidney". Biochem Biophys Res Commun. 283 (2): 417–22. doi:10.1006/bbrc.2001.4774. PMID 11327718.
↑ Shin HJ, Anzai N, Enomoto A, He X, Kim do K, Endou H, Kanai Y (Apr 2007). "Novel liver-specific organic anion transporter OAT7 that operates the exchange of sulfate conjugates for short chain fatty acid butyrate". Hepatology. 45 (4): 1046–55. doi: 10.1002/hep.21596 . PMID 17393504. S2CID 42571618.
↑ "Entrez Gene: SLC22A9 solute carrier family 22 (organic anion/cation transporter), member 9".

Zhou F, Hong M, You G (2007). "Regulation of human organic anion transporter 4 by progesterone and protein kinase C in human placental BeWo cells". Am. J. Physiol. Endocrinol. Metab. 293 (1): E57–61. doi:10.1152/ajpendo.00696.2006. PMID 17341544.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Ekaratanawong S, Anzai N, Jutabha P, et al. (2005). "Human organic anion transporter 4 is a renal apical organic anion/dicarboxylate exchanger in the proximal tubules". J. Pharmacol. Sci. 94 (3): 297–304. doi: 10.1254/jphs.94.297 . PMID 15037815.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ugele B, St-Pierre MV, Pihusch M, et al. (2003). "Characterization and identification of steroid sulfate transporters of human placenta". Am. J. Physiol. Endocrinol. Metab. 284 (2): E390–8. doi:10.1152/ajpendo.00257.2002. PMID 12409283. S2CID 348962.
Cha SH, Sekine T, Kusuhara H, et al. (2000). "Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta". J. Biol. Chem. 275 (6): 4507–12. doi: 10.1074/jbc.275.6.4507 . PMID 10660625.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000149742 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11327718-3] Sun W, Wu RR, van Poelje PD, Erion MD (Apr 2001). "Isolation of a family of organic anion transporters from human liver and kidney". Biochem Biophys Res Commun. 283 (2): 417–22. doi:10.1006/bbrc.2001.4774. PMID 11327718.

[pmid17393504-4] Shin HJ, Anzai N, Enomoto A, He X, Kim do K, Endou H, Kanai Y (Apr 2007). "Novel liver-specific organic anion transporter OAT7 that operates the exchange of sulfate conjugates for short chain fatty acid butyrate". Hepatology. 45 (4): 1046–55. doi: 10.1002/hep.21596 . PMID 17393504. S2CID 42571618.

[entrez-5] "Entrez Gene: SLC22A9 solute carrier family 22 (organic anion/cation transporter), member 9".

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SLC22A9

Contents

See also

Related Research Articles

References

Further reading