SLC12A8

SLC12A8
Identifiers
Aliases	SLC12A8 , CCC9, solute carrier family 12 member 8
External IDs	OMIM: 611316; MGI: 2443672; HomoloGene: 11628; GeneCards: SLC12A8; OMA:SLC12A8 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q21.2 Start 125,082,636 bp [1] End 125,212,864 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16|16 B3 Start 33,337,698 bp [2] End 33,484,505 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland left lobe of thyroid gland oocyte parotid gland periodontal fiber gallbladder decidua secondary oocyte body of pancreas pancreatic ductal cell Top expressed in gastrula submandibular gland parotid gland crypt of lieberkuhn of small intestine duodenum large intestine colon pyloric antrum ileum jejunum More reference expression data BioGPS n/a
Gene ontology Molecular function symporter activity potassium:chloride symporter activity Cellular component integral component of membrane membrane Biological process potassium ion transport ion transport transmembrane transport potassium ion transmembrane transport cell volume homeostasis chloride ion homeostasis potassium ion homeostasis chloride transmembrane transport potassium ion import across plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84561 171286 Ensembl ENSG00000221955 ENSMUSG00000035506 UniProt A0AV02 H7C5L2 Q8VI23 RefSeq (mRNA) NM_024628 NM_001195483 NM_001083902 NM_134251 NM_001370999 RefSeq (protein) NP_001182412 NP_078904 NP_001077371 NP_599012 NP_001357928 Location (UCSC) Chr 3: 125.08 – 125.21 Mb Chr 16: 33.34 – 33.48 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Solute carrier family 12 member 8 (SLC12A8), also known as cation-chloride cotransporter 9 (CCC9), is a protein that in humans is encoded by the SLC12A8 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000221955 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035506 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: solute carrier family 12 (potassium/chloride transporters)".
6. Hewett D, Samuelsson L, Polding J, Enlund F, Smart D, Cantone K, See CG, Chadha S, Inerot A, Enerback C, Montgomery D, Christodolou C, Robinson P, Matthews P, Plumpton M, Wahlstrom J, Swanbeck G, Martinsson T, Roses A, Riley J, Purvis I (March 2002). "Identification of a psoriasis susceptibility candidate gene by linkage disequilibrium mapping with a localized single nucleotide polymorphism map". Genomics. 79 (3): 305–14. doi:10.1006/geno.2002.6720. PMID   11863360.

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (September 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence". Nature. 377 (6547 Suppl): 3–174. PMID   7566098.
• Daigle ND, Carpentier GA, Frenette-Cotton R, Simard MG, Lefoll MH, Noël M, Caron L, Noël J, Isenring P (September 2009). "Molecular characterization of a human cation-Cl- cotransporter (SLC12A8A, CCC9A) that promotes polyamine and amino acid transport". Journal of Cellular Physiology. 220 (3): 680–9. doi:10.1002/jcp.21814. PMID   19472210. S2CID   28766587.
• Hebert SC, Mount DB, Gamba G (February 2004). "Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family". Pflügers Archiv. 447 (5): 580–93. doi:10.1007/s00424-003-1066-3. PMID   12739168. S2CID   21998913.
• Hüffmeier U, Lascorz J, Traupe H, Böhm B, Schürmeier-Horst F, Ständer M, Kelsch R, Baumann C, Küster W, Burkhardt H, Reis A (November 2005). "Systematic linkage disequilibrium analysis of SLC12A8 at PSORS5 confirms a role in susceptibility to psoriasis vulgaris". The Journal of Investigative Dermatology. 125 (5): 906–12. doi: 10.1111/j.0022-202X.2005.23847.x . PMID   16297188.