SLC45A4

Last updated
SLC45A4
Identifiers
Aliases SLC45A4 , solute carrier family 45 member 4
External IDs MGI: 2146236 HomoloGene: 69908 GeneCards: SLC45A4
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001080431
NM_001286646
NM_001286648

NM_001033219
NM_001168255
NM_001357747

RefSeq (protein)

NP_001073900
NP_001273575
NP_001273577

NP_001028391
NP_001161727
NP_001344676

Location (UCSC) Chr 8: 141.21 – 141.31 Mb Chr 15: 73.58 – 73.65 Mb
PubMed search [3] [4]
Wikidata
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SLC45A4 is a member of the SLC45 family of solute carriers. Analysis of the protein function in a recombinant yeast expression assay show that it can: (i) transport a disaccharide, sucrose, as well simple sugars such as glucose and fructose (ii) perform secondary active transport in a proton-dependent manner. [5]

It is associated with sugar transport in the spermatozoa. [6] Additionally, it has been identified as a necessary component in the cell death caused of the compound paraquat. [7]

Related Research Articles

Peptide transporter 1

Peptide transporter 1 also known as solute carrier family 15 member 1 (SLC15A1) is a protein that in humans is encoded by SLC15A1 gene. PepT 1 is a solute carrier for oligopeptides. It functions in renal oligopeptide reabsorption and in the intestines in a proton dependent way, hence acting like a cotransporter.

SLC23A2

Solute carrier family 23 member 2 is a protein that in humans is encoded by the SLC23A2 gene.

Proton-coupled amino acid transporter 1

Proton-coupled amino acid transporter 1 is a protein that in humans is encoded by the SLC36A1 gene.

Mitochondrial uncoupling protein 4

Mitochondrial uncoupling protein 4 is a protein that in humans is encoded by the SLC25A27 gene.

SLC15A2

Solute carrier family 15, member 2, also known as SLC15A2, is a human gene.

Monocarboxylate transporter 4

Monocarboxylate transporter 4 (MCT4) also known as solute carrier family 16 member 3 is a protein that in humans is encoded by the SLC16A3 gene.

SLC2A6

Solute carrier family 2, facilitated glucose transporter member 6 is a protein that in humans is encoded by the SLC2A6 gene.

SLC2A9

Solute carrier family 2, facilitated glucose transporter member 9 is a protein that in humans is encoded by the SLC2A9 gene.

SLC13A3

Solute carrier family 13 member 3 also called sodium-dependent dicarboxylate transporter (NaDC3) is a protein that in humans is encoded by the SLC13A3 gene.

SLC27A6

Long-chain fatty acid transport protein 6 is a protein that in humans is encoded by the SLC27A6 gene.

Cationic amino acid transporter 2

Cationic amino acid transporter 2 is a protein that in humans is encoded by the SLC7A2 gene.

Cationic amino acid transporter 4 Protein-coding gene in the species Homo sapiens

Cationic amino acid transporter 4 is a protein that in humans is encoded by the SLC7A4 gene.

SLC6A18

Solute carrier family 6, member 18 also known as SLC6A18 is a protein which in humans is encoded by the SLC6A18 gene.

Monocarboxylate transporter 10

Monocarboxylate transporter 10, also known as aromatic amino acid transporter 1 and T-type amino acid transporter 1 (TAT1) and solute carrier family 16 member 10 (SLC16A10), is a protein that in humans is encoded by the SLC16A10 gene. SLC16A10 is a member of the solute carrier family.

SLC2A13

Proton myo-inositol cotransporter, also known as solute carrier family 2 member 13 is a protein that in humans is encoded by the SLC2A13 gene.

SLC2A14

Solute carrier family 2, member 14 is a protein that in humans is encoded by the SLC2A14 gene.

Zinc transporter 3

Zinc transporter 3 also known as solute carrier family 30 member 3 is a protein in humans that is encoded by the SLC30A3 gene.

Monocarboxylate transporter 2

Monocarboxylate transporter 2 (MCT2) also known as solute carrier family 16 member 7 (SLC16A7) is a protein that in humans is encoded by the SLC16A7 gene. MCT2 is a proton-coupled monocarboxylate transporter. It catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate and beta-hydroxybutyrate. It also functions as high-affinity pyruvate transporter.

SLC45A1

SLC45A1 is a member of the SLC45 family of solute carriers. Analysis of the protein function in a recombinant yeast expression assay show that it can: (i) transport a disaccharide, such as glucose and sucrose (ii) perform secondary active transport in a proton-dependent manner.

SLC22A14

Solute carrier family 22 member 14 is a protein that in humans is encoded by the SLC22A14 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000022567 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000079020 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Bartölke R, Heinisch JJ, Wieczorek H, Vitavska O (December 2014). "Proton-associated sucrose transport of mammalian solute carrier family 45: an analysis in Saccharomyces cerevisiae". The Biochemical Journal. 464 (2): 193–201. doi:10.1042/BJ20140572. PMID   25164149.
  6. Vitavska O, Wieczorek H (November 2017). "+/sugar cotransporter in mammalian spermatozoa". Pflügers Archiv. 469 (11): 1433–1442. doi:10.1007/s00424-017-2024-9. PMC   5629229 . PMID   28689241.
  7. Reczek CR, Birsoy K, Kong H, Martínez-Reyes I, Wang T, Gao P, et al. (December 2017). "A CRISPR screen identifies a pathway required for paraquat-induced cell death". Nature Chemical Biology. 13 (12): 1274–1279. doi:10.1038/nchembio.2499. PMC   5698099 . PMID   29058724.