SLC17A3

SLC17A3
Identifiers
Aliases	SLC17A3 , NPT4, GOUT4, UAQTL4, solute carrier family 17 member 3
External IDs	OMIM: 611034 MGI: 2389216 HomoloGene: 21319 GeneCards: SLC17A3
Gene location (Human)
Chr.	Chromosome 6 (human)
End	25,882,286 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	24,044,699 bp
RNA expression pattern
	Top expressed in
	kidney tubule; ; kidney; ; right lobe of liver; ; glomerulus; ; metanephric glomerulus; ; renal medulla; ; Right adrenal gland; ; Left adrenal gland; ; ascending aorta; ; anterior pituitary;
	Top expressed in
	kidney; ; proximal tubule; ; left lobe of liver; ; outer renal medulla; ; outer stripe of outer renal medulla; ; glomerulus; ; distal tubule; ; proximal straight tubule; ; proximal convoluted tubule; ; inner renal medulla;
	More reference expression data
	n/a
Gene ontology
Molecular function	efflux transmembrane transporter activity ; voltage-gated anion channel activity ; xenobiotic transmembrane transporter activity ; toxin transmembrane transporter activity ; symporter activity ; organic anion transmembrane transporter activity ; sodium:phosphate symporter activity ; urate transmembrane transporter activity ; sialic acid transmembrane transporter activity ;
Cellular component	brush border membrane ; integral component of membrane ; perinuclear region of cytoplasm ; membrane ; endoplasmic reticulum ; integral component of plasma membrane ; plasma membrane ; cytoplasm ; endoplasmic reticulum membrane ; apical plasma membrane ; lysosome ;
Biological process	sodium ion transport ; sodium ion transmembrane transport ; ion transmembrane transport ; glucose-6-phosphate transport ; organic anion transport ; urate metabolic process ; phosphate ion transport ; urate transport ; ion transport ; toxin transport ; xenobiotic transmembrane transport ; transmembrane transport ; sialic acid transport ; xenobiotic detoxification by transmembrane export across the plasma membrane ;
	Sources:Amigo / QuickGO
Orthologs
	10786
	105355
	ENSG00000124564
	ENSMUSG00000036083
	O00476
	n/a
	NM_006632 ; NM_001098486
	NM_001164743 ; NM_134069
	NP_001091956 ; NP_006623
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 10, 2023

Solute carrier family 17 (organic anion transporter), member 3 is a protein that in humans is encoded by the SLC17A3 gene.^[5]

Function

The protein encoded by this gene is a voltage-driven transporter that excretes intracellular urate and organic anions from the blood into renal tubule cells. Two transcript variants encoding different isoforms have been found for this gene. The longer isoform is a plasma membrane protein with transporter activity while the shorter isoform localizes to the endoplasmic reticulum.^[5]

Related Research Articles

The sodium/phosphate cotransporter is a member of the phosphate:Na⁺ symporter (PNaS) family within the TOG Superfamily of transport proteins as specified in the Transporter Classification Database (TCDB).

Glucose-6-phosphate exchanger SLC37A4, also known as glucose-6-phosphate translocase, is an enzyme that in humans is encoded by the SLC37A4 gene.

Solute carrier family 22 member 1 is a protein that in humans is encoded by the gene SLC22A1.

Solute carrier family 22 member 11 is a protein that in humans is encoded by the SLC22A11 gene.

Solute carrier family 26 member 6 is a protein that in humans is encoded by the SLC26A6 gene. It is an anion-exchanger expressed in the apical membrane of the kidney proximal tubule, the apical membranes of the duct cells in the pancreas, and the villi of the duodenum.

Solute carrier family 22 member 8, or organic anion transporter 3 (OAT3), is a protein that in humans is encoded by the SLC22A8 gene.

Solute carrier family 22, member 12, also known as SLC22A12 and URAT1, is a protein which in humans is encoded by the SLC22A12 gene.

Solute carrier organic anion transporter family member 1A2 is a protein that in humans is encoded by the SLCO1A2 gene.

Solute carrier organic anion transporter family member 2B1 also known as organic anion-transporting polypeptide 2B1 (OATP2B1) is a protein that in humans is encoded by the gene SLCO2B1.

Solute carrier family 2, facilitated glucose transporter member 9 is a protein that in humans is encoded by the SLC2A9 gene.

Sodium-dependent phosphate transport protein 1 is a protein that in humans is encoded by the SLC17A1 gene.

Solute carrier family 22 member 7 is a protein that in humans is encoded by the gene SLC22A7.

Solute carrier family 22 member 9 is a protein that in humans is encoded by the SLC22A9 gene.

Testis anion transporter 1 is a protein that in humans is encoded by the SLC26A8 gene.

The organic anion transporter 1 (OAT1) also known as solute carrier family 22 member 6 (SLC22A6) is a protein that in humans is encoded by the SLC22A6 gene. It is a member of the organic anion transporter (OAT) family of proteins. OAT1 is a transmembrane protein that is expressed in the brain, the placenta, the eyes, smooth muscles, and the basolateral membrane of proximal tubular cells of the kidneys. It plays a central role in renal organic anion transport. Along with OAT3, OAT1 mediates the uptake of a wide range of relatively small and hydrophilic organic anions from plasma into the cytoplasm of the proximal tubular cells of the kidneys. From there, these substrates are transported into the lumen of the nephrons of the kidneys for excretion. OAT1 homologs have been identified in rats, mice, rabbits, pigs, flounders, and nematodes.

Solute carrier family 22 member 25 (SLC22A25), also known as organic anion transporter UST6, is a protein that in humans is encoded by the SLC22A25 gene.

Monocarboxylate transporter 10, also known as aromatic amino acid transporter 1 and T-type amino acid transporter 1 (TAT1) and solute carrier family 16 member 10 (SLC16A10), is a protein that in humans is encoded by the SLC16A10 gene. SLC16A10 is a member of the solute carrier family.

Monocarboxylate transporter 9 is a protein that in humans is encoded by the SLC16A9 gene.

Solute carrier organic anion transporter family member 2A1, also known as the prostaglandin transporter (PGT), is a protein that in humans is encoded by the SLCO2A1 gene.

Solute carrier family 22 member 13 is a protein that in humans is encoded by the SLC22A13 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000124564 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036083 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: Solute carrier family 17 (organic anion transporter), member 3".

Polasek O, Jeroncić I, Mulić R, Klismanic Z, Pehlić M, Zemunik T, Kolcić I (2010). "Common variants in SLC17A3 gene affect intra-personal variation in serum uric acid levels in longitudinal time series". Croat. Med. J. 51 (1): 32–9. doi:10.3325/cmj.2010.51.32. PMC 2829186 . PMID 20162743.
Dehghan A, Köttgen A, Yang Q, Hwang SJ, Kao WL, Rivadeneira F, Boerwinkle E, Levy D, Hofman A, Astor BC, Benjamin EJ, van Duijn CM, Witteman JC, Coresh J, Fox CS (2008). "Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study". Lancet. 372 (9654): 1953–61. doi:10.1016/S0140-6736(08)61343-4. PMC 2803340 . PMID 18834626.
Ruddy DA, Kronmal GS, Lee VK, Mintier GA, Quintana L, Domingo R, Meyer NC, Irrinki A, McClelland EE, Fullan A, Mapa FA, Moore T, Thomas W, Loeb DB, Harmon C, Tsuchihashi Z, Wolff RK, Schatzman RC, Feder JN (1997). "A 1.1-Mb transcript map of the hereditary hemochromatosis locus". Genome Res. 7 (5): 441–56. doi: 10.1101/gr.7.5.441 . PMID 9149941.
Jutabha P, Anzai N, Kitamura K, Taniguchi A, Kaneko S, Yan K, Yamada H, Shimada H, Kimura T, Katada T, Fukutomi T, Tomita K, Urano W, Yamanaka H, Seki G, Fujita T, Moriyama Y, Yamada A, Uchida S, Wempe MF, Endou H, Sakurai H (2010). "Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate". J. Biol. Chem. 285 (45): 35123–32. doi: 10.1074/jbc.M110.121301 . PMC 2966126 . PMID 20810651.
Stark K, Reinhard W, Grassl M, Erdmann J, Schunkert H, Illig T, Hengstenberg C (2009). "Common polymorphisms influencing serum uric acid levels contribute to susceptibility to gout, but not to coronary artery disease". PLOS ONE. 4 (11): e7729. Bibcode:2009PLoSO...4.7729S. doi: 10.1371/journal.pone.0007729 . PMC 2766838 . PMID 19890391.
Jutabha P, Anzai N, Kimura T, Taniguchi A, Urano W, Yamanaka H, Endou H, Sakurai H (2011). "Functional analysis of human sodium-phosphate transporter 4 (NPT4/SLC17A3) polymorphisms". J. Pharmacol. Sci. 115 (2): 249–53. doi: 10.1254/jphs.10228sc . PMID 21282933.
Melis D, Havelaar AC, Verbeek E, Smit GP, Benedetti A, Mancini GM, Verheijen F (2004). "NPT4, a new microsomal phosphate transporter: mutation analysis in glycogen storage disease type Ic". J. Inherit. Metab. Dis. 27 (6): 725–33. doi:10.1023/B:BOLI.0000045755.89308.2f. PMID 15505377. S2CID 20942710.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000124564 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036083 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: Solute carrier family 17 (organic anion transporter), member 3".

[1]

[2]

[3]

[4]

[5]

v t e Genetic disorder, membrane: Solute carrier disorders
1-10	SLC1A3 Episodic ataxia 6 SLC2A1 De Vivo disease SLC2A2 Fanconi-Bickel syndrome SLC2A5 Fructose malabsorption SLC2A10 Arterial tortuosity syndrome SLC3A1 Cystinuria SLC4A1 Hereditary spherocytosis 4/Hereditary elliptocytosis 4 SLC4A11 Congenital endothelial dystrophy type 2 Fuchs' dystrophy 4 SLC5A1 Glucose-galactose malabsorption SLC5A2 Renal glycosuria SLC5A5 Thyroid dyshormonogenesis type 1 SLC6A19 Hartnup disease SLC7A7 Lysinuric protein intolerance SLC7A9 Cystinuria
11-20	SLC11A1 Crohn's disease SLC12A3 Gitelman syndrome SLC16A1 HHF7 SLC16A2 Allan–Herndon–Dudley syndrome SLC17A3 Von Gierke's disease, GSD-Ic SLC17A5 Salla disease SLC17A8 DFNA25
21-40	SLC26A2 Multiple epiphyseal dysplasia 4 Achondrogenesis type 1B Recessive multiple epiphyseal dysplasia Atelosteogenesis, type II Diastrophic dysplasia SLC26A4 Pendred syndrome SLC35C1 CDOG 2C SLC37A4 Von Gierke's disease, GSD-Ib SLC39A4 Acrodermatitis enteropathica SLC40A1 African iron overload
see also solute carrier family

SLC17A3

Contents

Function

See also

Related Research Articles

References

Further reading