SLC22A2

SLC22A2
Identifiers
Aliases	SLC22A2 , OCT2, solute carrier family 22 member 2
External IDs	OMIM: 602608 MGI: 1335072 HomoloGene: 68293 GeneCards: SLC22A2
Gene location (Human)
Chr.	Chromosome 6 (human) [1]
End	160,277,638 bp [1]
Gene location (Mouse)
Chr.	Chromosome 17 (mouse) [2]
End	12,628,488 bp [2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• GO:0022891 transmembrane transporter activity ; • transporter activity ; • neurotransmitter transporter activity ; • quaternary ammonium group transmembrane transporter activity ; • organic cation transmembrane transporter activity ; • acetylcholine transmembrane transporter activity ; • GO:0005333 norepinephrine:sodium symporter activity ; • secondary active organic cation transmembrane transporter activity ; • organic anion transmembrane transporter activity ;
Cellular component	• integral component of membrane ; • membrane ; • cell membrane ; • extracellular exosome ; • integral component of plasma membrane ; • presynapse ;
Biological process	• drug transmembrane transport ; • body fluid secretion ; • quaternary ammonium group transport ; • neurotransmitter biosynthetic process ; • cation transport ; • ion transport ; • dopamine transport ; • GO:0010554 neurotransmitter secretion ; • organic cation transport ; • transmembrane transport ; • ammonium transmembrane transport ; • neurotransmitter transport ; • organic anion transport ; • norepinephrine transport ; • acetate ester transport ; • transport ;
	Sources:Amigo / QuickGO
Orthologs
	6582
	20518
	ENSG00000112499
	ENSMUSG00000040966
	O15244
	O70577
	NM_153191 ; NM_003058
	NM_013667 ; NM_001355767
	NP_003049
	NP_038695 ; NP_001342696
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 12, 2020

Solute carrier family 22 member 2 (also termed OCT2 or organic cation transporter-2^[5]) is a protein that in humans is encoded by the SLC22A2 gene.^[6]^[7]

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption.^[7]

Related Research Articles

Solute carrier family 22, member 4, also known as SLC22A4, is a human gene; the encoded protein is known as the ergothioneine transporter.

Solute carrier family 22 member 1 is a protein that in humans is encoded by the gene SLC22A1.

Solute carrier family 23 member 2 is a protein that in humans is encoded by the SLC23A2 gene.

Solute carrier family 22 member 3 (SLC22A3) also known as the organic cation transporter 3 (OCT3) or extraneuronal monoamine transporter (EMT) is a protein that in humans is encoded by the SLC22A3 gene.

Solute carrier family 22 member 11 is a protein that in humans is encoded by the SLC22A11 gene.

Solute carrier organic anion transporter family member 1A2 is a protein that in humans is encoded by the SLCO1A2 gene.

Zinc transporter ZIP2 is a protein that in humans is encoded by the SLC39A2 gene.

Multidrug and toxin extrusion protein 1 (MATE1), also known as solute carrier family 47 member 1, is a protein that in humans is encoded by the SLC47A1 gene. SLC47A1 belongs to the MATE family of transporters that are found in bacteria, archaea and eukaryotes.

Cationic amino acid transporter 3 is a protein that in humans is encoded by the SLC7A3 gene.

Solute carrier family 2, facilitated glucose transporter member 9 is a protein that in humans is encoded by the SLC2A9 gene.

Solute carrier family 22 member 7 is a protein that in humans is encoded by the gene SLC22A7.

Solute carrier family 22 member 9 is a protein that in humans is encoded by the SLC22A9 gene.

Long-chain fatty acid transport protein 6 is a protein that in humans is encoded by the SLC27A6 gene.

Cationic amino acid transporter 4 is a protein that in humans is encoded by the SLC7A4 gene.

Solute carrier family 6, member 18 also known as SLC6A18 is a protein which in humans is encoded by the SLC6A18 gene.

The plasma membrane monoamine transporter (PMAT) is a low-affinity monoamine transporter protein which in humans is encoded by the SLC29A4 gene. It is known alternatively as the human equilibrative nucleoside transporter-4 (hENT4). Unlike other members of the ENT family, it is impermeable to most nucleosides, with the exception of the inhibitory neurotransmitter and ribonucleoside adenosine, which it is permeable to in a highly pH-dependent manner.

Solute carrier family 22 member 25 (SLC22A25), also known as organic anion transporter UST6, is a protein that in humans is encoded by the SLC22A25 gene.

Monocarboxylate transporter 10, also known as aromatic amino acid transporter 1 and T-type amino acid transporter 1 (TAT1) and solute carrier family 16 member 10 (SLC16A10), is a protein that in humans is encoded by the SLC16A10 gene. SLC16A10 is a member of the solute carrier family.

Solute carrier family 12 member 9 (SLC12A9), also known as cation-chloride cotransporter 6 (CCC6) or cation-chloride cotransporter-interacting protein 1 (CIP1), is a protein that in humans is encoded by the SLC12A9 gene.

Solute carrier family 22 member 13 is a protein that in humans is encoded by the SLC22A13 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000112499 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040966 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "SLC22A2 solute carrier family 22 member 2 [Homo sapiens (human)] - Gene - NCBI".
↑ Koehler MR, Wissinger B, Gorboulev V, Koepsell H, Schmid M (Jun 1998). "The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26". Cytogenet Cell Genet. 79 (3–4): 198–200. doi:10.1159/000134720. PMID 9605850.
1 2 "Entrez Gene: SLC22A2 solute carrier family 22 (organic cation transporter), member 2".

Berkhout B, Jeang KT (1992). "Functional roles for the TATA promoter and enhancers in basal and Tat-induced expression of the human immunodeficiency virus type 1 long terminal repeat". J. Virol. 66 (1): 139–49. doi:10.1128/JVI.66.1.139-149.1992. PMC 238269 . PMID 1727476.
Jeang KT, Chun R, Lin NH, et al. (1993). "In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor". J. Virol. 67 (10): 6224–33. doi:10.1128/JVI.67.10.6224-6233.1993. PMC 238044 . PMID 7690421.
Liu YZ, Lania L, Latchman DS (1997). "Functional interaction between the HIV-1 Tat transactivator and the inhibitory domain of the Oct-2 cellular transcription factor". AIDS. 10 (12): 1323–9. doi:10.1097/00002030-199610000-00003. PMID 8902060. S2CID 11659500.
Liu YZ, Latchman DS (1997). "The octamer-binding proteins Oct-1 and Oct-2 repress the HIV long terminal repeat promoter and its transactivation by Tat". Biochem. J. 322 (1): 155–8. doi:10.1042/bj3220155. PMC 1218171 . PMID 9078256.
Gorboulev V, Ulzheimer JC, Akhoundova A, et al. (1997). "Cloning and characterization of two human polyspecific organic cation transporters". DNA Cell Biol. 16 (7): 871–81. doi:10.1089/dna.1997.16.871. PMID 9260930.
Busch AE, Karbach U, Miska D, et al. (1998). "Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine". Mol. Pharmacol. 54 (2): 342–52. doi:10.1124/mol.54.2.342. PMID 9687576.
Verhaagh S, Schweifer N, Barlow DP, Zwart R (1999). "Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27". Genomics. 55 (2): 209–18. doi:10.1006/geno.1998.5639. PMID 9933568.
Gründemann D, Schömig E (2000). "Gene structures of the human non-neuronal monoamine transporters EMT and OCT2". Hum. Genet. 106 (6): 627–35. doi:10.1007/s004390050035. PMID 10942111.
Pietig G, Mehrens T, Hirsch JR, et al. (2001). "Properties and regulation of organic cation transport in freshly isolated human proximal tubules". J. Biol. Chem. 276 (36): 33741–6. doi: 10.1074/jbc.M104617200 . PMID 11447227.
Boehm J, He Y, Greiner A, et al. (2001). "Regulation of BOB.1/OBF.1 stability by SIAH". EMBO J. 20 (15): 4153–62. doi:10.1093/emboj/20.15.4153. PMC 149152 . PMID 11483518.
Barendt WM, Wright SH (2002). "The human organic cation transporter (hOCT2) recognizes the degree of substrate ionization". J. Biol. Chem. 277 (25): 22491–6. doi: 10.1074/jbc.M203114200 . PMID 11953440.
Urakami Y, Akazawa M, Saito H, et al. (2002). "cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney". J. Am. Soc. Nephrol. 13 (7): 1703–10. doi: 10.1097/01.ASN.0000019413.78751.46 . PMID 12089365.
Leabman MK, Huang CC, Kawamoto M, et al. (2003). "Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function". Pharmacogenetics. 12 (5): 395–405. doi:10.1097/00008571-200207000-00007. PMID 12142729.
Cetinkaya I, Ciarimboli G, Yalçinkaya G, et al. (2003). "Regulation of human organic cation transporter hOCT2 by PKA, PI3K, and calmodulin-dependent kinases". Am. J. Physiol. Renal Physiol. 284 (2): F293–302. doi:10.1152/ajprenal.00251.2002. PMID 12388397.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 . PMID 12477932.
Gründemann D, Hahne C, Berkels R, Schömig E (2003). "Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2)". J. Pharmacol. Exp. Ther. 304 (2): 810–7. doi:10.1124/jpet.102.044404. PMID 12538837. S2CID 11496882.
Bottalico B, Larsson I, Brodszki J, et al. (2004). "Norepinephrine transporter (NET), serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in human placenta from pre-eclamptic and normotensive pregnancies". Placenta. 25 (6): 518–29. doi:10.1016/j.placenta.2003.10.017. PMID 15135235.
Lips KS, Volk C, Schmitt BM, et al. (2005). "Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium". Am. J. Respir. Cell Mol. Biol. 33 (1): 79–88. CiteSeerX 10.1.1.327.6767 . doi:10.1165/rcmb.2004-0363OC. PMID 15817714.
Jiang W, Prokopenko O, Wong L, et al. (2005). "IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity". Mol. Cell. Biol. 25 (15): 6496–508. doi:10.1128/MCB.25.15.6496-6508.2005. PMC 1190334 . PMID 16024787.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000112499 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040966 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "SLC22A2 solute carrier family 22 member 2 [Homo sapiens (human)] - Gene - NCBI".

[pmid9605850-6] Koehler MR, Wissinger B, Gorboulev V, Koepsell H, Schmid M (Jun 1998). "The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26". Cytogenet Cell Genet. 79 (3–4): 198–200. doi:10.1159/000134720. PMID 9605850.

[entrez-7] 1 2 "Entrez Gene: SLC22A2 solute carrier family 22 (organic cation transporter), member 2".

SLC22A2

Contents

See also

Related Research Articles

References

Further reading