SLC35C2

SLC35C2
Identifiers
Aliases	SLC35C2 , BA394O2.1, C20orf5, CGI-15, OVCOV1, solute carrier family 35 member C2
External IDs	MGI: 2385166 HomoloGene: 6581 GeneCards: SLC35C2
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20q13.12 Start 46,345,980 bp [1] End 46,364,458 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2 H3|2 85.53 cM Start 165,118,474 bp [2] End 165,129,789 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube left lobe of thyroid gland right lobe of thyroid gland stromal cell of endometrium minor salivary gland canal of the cervix body of stomach skin of abdomen body of pancreas right lobe of liver Top expressed in lacrimal gland duodenum yolk sac jejunum superior frontal gyrus proximal tubule spermatocyte lip salivary gland cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function antiporter activity transmembrane transporter activity Cellular component integral component of membrane cis-Golgi network endoplasmic reticulum-Golgi intermediate compartment membrane membrane endoplasmic reticulum-Golgi intermediate compartment nucleoplasm Golgi apparatus Biological process protein O-linked fucosylation fucosylation negative regulation of gene expression positive regulation of Notch signaling pathway UDP-glucose transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51006 228875 Ensembl ENSG00000080189 ENSMUSG00000017664 UniProt Q9NQQ7 Q8VCX2 RefSeq (mRNA) NM_001281457 NM_001281458 NM_001281459 NM_001281460 NM_015945 NM_173073 NM_173179 NM_001252573 NM_001252574 NM_001252575 NM_144893 NM_001363015 NM_001363016 RefSeq (protein) NP_001268386 NP_001268387 NP_001268388 NP_001268389 NP_057029 NP_775096 NP_775271 NP_001239502 NP_001239503 NP_001239504 NP_659142 NP_001349944 NP_001349945 Location (UCSC) Chr 20: 46.35 – 46.36 Mb Chr 2: 165.12 – 165.13 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Solute carrier family 35 member C2 is a protein that in humans is encoded by the SLC35C2 gene. ^{[5] [6] [7]}

Oxygenation levels play an important role in the regulation of cellular invasiveness which occurs during early implantation when the trophoblast cells invade the uterus as well as during tumour progression and metastasis. This gene, which is regulated by oxygen tension, is induced in hypoxic trophoblast cells and is overexpressed in ovarian cancer. Two protein isoforms are encoded by transcript variants of this gene. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000080189 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000017664 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC   310876 . PMID   10810093.
6. Fossey SC, Mychaleckyj JC, Pendleton JK, Snyder JR, Bensen JT, Hirakawa S, Rich SS, Freedman BI, Bowden DW (Sep 2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20". Genomics. 76 (1–3): 45–57. doi:10.1006/geno.2001.6584. PMID   11549316.
7. "Entrez Gene: SLC35C2 solute carrier family 35, member C2".

Further reading

• Lash GE, Postovit LM, Matthews NE, et al. (2002). "Oxygen as a regulator of cellular phenotypes in pregnancy and cancer". Can. J. Physiol. Pharmacol. 80 (2): 103–9. doi:10.1139/y02-008. PMID   11934252.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Pires Martins R, Leach RE, Krawetz SA (2001). "Whole-body gene expression by data mining". Genomics. 72 (1): 34–42. doi:10.1006/geno.2000.6437. PMID   11247664.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Leach R, Duniec-Dmuchowski Z, Tanaka T, et al. (2002). "Assignment of OVCOV1 (alias CGI-15) to human chromosome 20 band q13.1→q13.2 by fluorescent in situ hybridization". Cytogenet. Cell Genet. 94 (3–4): 252–3. doi:10.1159/000048828. PMID   11856893. S2CID   33594704.
• Leach RE, Duniec-Dmuchowski ZM, Pesole G, et al. (2003). "Identification, molecular characterization, and tissue expression of OVCOV1". Mamm. Genome. 13 (11): 619–24. doi:10.1007/s00335-002-2185-4. PMID   12461647. S2CID   19423578.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.