Monocarboxylate transporter 9

SLC16A9
Identifiers
Aliases	SLC16A9 , C10orf36, MCT9, solute carrier family 16 member 9
External IDs	OMIM: 614242; MGI: 1914109; HomoloGene: 32642; GeneCards: SLC16A9; OMA:SLC16A9 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q21.2 Start 59,650,764 bp [1] End 59,736,002 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 B5.3 Start 70,080,930 bp [2] End 70,121,798 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left adrenal cortex right adrenal cortex nasal epithelium mucosa of colon mucosa of sigmoid colon mucosa of ileum human kidney gums gingival epithelium ventricular zone Top expressed in retinal pigment epithelium meninges right lung human kidney right kidney right lung lobe proximal tubule ciliary body lumbar spinal ganglion aortic valve More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding symporter activity monocarboxylic acid transmembrane transporter activity Cellular component plasma membrane membrane integral component of membrane integral component of plasma membrane Biological process urate metabolic process transmembrane transport monocarboxylic acid transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 220963 66859 Ensembl ENSG00000165449 ENSMUSG00000037762 UniProt Q7RTY1 Q7TM99 RefSeq (mRNA) NM_194298 NM_001323977 NM_001323978 NM_001323979 NM_001323980 NM_001323981 NM_025807 RefSeq (protein) NP_001310906 NP_001310907 NP_001310908 NP_001310909 NP_001310910 NP_919274 NP_080083 Location (UCSC) Chr 10: 59.65 – 59.74 Mb Chr 10: 70.08 – 70.12 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Monocarboxylate transporter 9 (MCT9, solute carrier family 16, member 9, SLC16A9) is a protein that in humans is encoded by the SLC16A9 gene. ^[5]

Clinical relevance

Mutations in the SLC16A9 gene have been associated with carnitine levels in blood. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000165449 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037762 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: solute carrier family 16".
6. Suhre K, Shin SY, Petersen AK, Mohney RP, Meredith D, Wägele B, Altmaier E, Deloukas P, Erdmann J, Grundberg E, Hammond CJ, de Angelis MH, Kastenmüller G, Köttgen A, Kronenberg F, Mangino M, Meisinger C, Meitinger T, Mewes HW, Milburn MV, Prehn C, Raffler J, Ried JS, Römisch-Margl W, Samani NJ, Small KS, Wichmann HE, Zhai G, Illig T, Spector TD, Adamski J, Soranzo N, Gieger C, Assimes TL, Deloukas P, Erdmann J, Holm H, Kathiresan S, König IR, McPherson R, Reilly MP, Roberts R, Samani NJ, Schunkert H, Stewart AF (September 2011). "Human metabolic individuality in biomedical and pharmaceutical research". Nature. 477 (7362): 54–60. Bibcode:2011Natur.477...54S. doi:10.1038/nature10354. PMC   3832838 . PMID   21886157.

Further reading

• Kolz M, Johnson T, Sanna S, et al. (2009). "Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations". PLOS Genet. 5 (6): e1000504. doi: 10.1371/journal.pgen.1000504 . PMC   2683940 . PMID   19503597.
• Gunjaca G; Boban M; Pehlić M; et al. (2010). "Predictive value of 8 genetic loci for serum uric acid concentration". Croat. Med. J. 51 (1): 23–31. doi:10.3325/cmj.2010.51.23. PMC   2829178 . PMID   20162742.
• Grupe A, Li Y, Rowland C, et al. (2006). "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease". Am. J. Hum. Genet. 78 (1): 78–88. doi:10.1086/498851. PMC   1380225 . PMID   16385451.
• Polasek O; Jeroncić I; Mulić R; et al. (2010). "Common variants in SLC17A3 gene affect intra-personal variation in serum uric acid levels in longitudinal time series". Croat. Med. J. 51 (1): 32–9. doi:10.3325/cmj.2010.51.32. PMC   2829186 . PMID   20162743.
• Stark K, Reinhard W, Grassl M, et al. (2009). "Common polymorphisms influencing serum uric acid levels contribute to susceptibility to gout, but not to coronary artery disease". PLOS ONE. 4 (11): e7729. Bibcode:2009PLoSO...4.7729S. doi: 10.1371/journal.pone.0007729 . PMC   2766838 . PMID   19890391.
• van der Harst P, Bakker SJ, de Boer RA, et al. (2010). "Replication of the five novel loci for uric acid concentrations and potential mediating mechanisms". Hum. Mol. Genet. 19 (2): 387–95. doi: 10.1093/hmg/ddp489 . PMID   19861489.
• Illig T, Gieger C, Zhai G, et al. (2010). "A genome-wide perspective of genetic variation in human metabolism". Nat. Genet. 42 (2): 137–41. doi:10.1038/ng.507. PMC   3773904 . PMID   20037589.
• Halestrap AP, Meredith D (2004). "The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond". Pflügers Arch. 447 (5): 619–28. doi:10.1007/s00424-003-1067-2. PMID   12739169. S2CID   15498611.