SLC22A4

Last updated
SLC22A4
Identifiers
Aliases SLC22A4 , OCTN1, solute carrier family 22 member 4, DFNB60
External IDs OMIM: 604190 MGI: 1353479 HomoloGene: 81701 GeneCards: SLC22A4
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003059

NM_019687
NM_001330304

RefSeq (protein)

NP_003050

NP_001317233
NP_062661

Location (UCSC) Chr 5: 132.29 – 132.34 Mb Chr 11: 53.87 – 53.92 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Solute carrier family 22, member 4, also known as SLC22A4, is a human gene; the encoded protein is known as the ergothioneine transporter. [5] [6]

Contents

Function

The encoded protein is an integral protein of the plasma membrane containing 12 transmembrane segments. The first functional designation of this protein was OCTN1 ("organic cation transporter, novel, type 1"), but efficiency of transport for organic cations (e.g., tetraethylammonium) is very low. The transport efficiency for carnitine is also negligible. Instead, the protein is responsible for the cotransport of sodium ions and ergothioneine, which is an antioxidant, into cells. [7] Thus, a more appropriate functional designation is ETT ("ergothioneine transporter"). [5]

Interactions

SLC22A4 has been shown to interact with PDZK1. [8]

See also

Related Research Articles

<span class="mw-page-title-main">SLC22A5</span> Protein-coding gene in the species Homo sapiens

SLC22A5 is a membrane transport protein associated with primary carnitine deficiency. This protein is involved in the active cellular uptake of carnitine. It acts a symporter, moving sodium ions and other organic cations across the membrane along with carnitine. Such polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for the elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. Mutations in the SLC22A5 gene cause systemic primary carnitine deficiency, which can lead to heart failure.

<span class="mw-page-title-main">SLC22A2</span> Protein-coding gene

Solute carrier family 22 member 2 is a protein that in humans is encoded by the SLC22A2 gene.

<span class="mw-page-title-main">SLC22A1</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 22 member 1 is a protein that in humans is encoded by the gene SLC22A1.

<span class="mw-page-title-main">Solute carrier organic anion transporter family member 1B1</span> Protein-coding gene in the species Homo sapiens

Solute carrier organic anion transporter family member 1B1 is a protein that in humans is encoded by the SLCO1B1 gene. Pharmacogenomic research indicates that genetic variations in this gene are associated with response to simvastatin. Clinical guidelines exist that can guide dosing of simvastatin based on SLCO1B1 gene variant using genotyping or whole exome sequencing.

<span class="mw-page-title-main">SLC22A3</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 22 member 3 (SLC22A3) also known as the organic cation transporter 3 (OCT3) or extraneuronal monoamine transporter (EMT) is a protein that in humans is encoded by the SLC22A3 gene.

<span class="mw-page-title-main">SLC22A11</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 22 member 11 is a protein that in humans is encoded by the SLC22A11 gene.

<span class="mw-page-title-main">Concentrative nucleoside transporter 1</span> The gene that determine size of cells

Concentrative nucleoside transporter 1 (CNT1) is a protein that in humans is encoded by the SLC28A1 gene.

<span class="mw-page-title-main">SLC22A12</span> Mammalian protein found in Homo sapiens

Solute carrier family 22, member 12, also known as SLC22A12 and URAT1, is a protein which in humans is encoded by the SLC22A12 gene.

<span class="mw-page-title-main">Solute carrier organic anion transporter family member 1A2</span>

Solute carrier organic anion transporter family member 1A2 is a protein that in humans is encoded by the SLCO1A2 gene.

<span class="mw-page-title-main">PDZK1IP1</span> Protein-coding gene in the species Homo sapiens

PDZK1-interacting protein 1 is a protein that in humans is encoded by the PDZK1IP1 gene.

<span class="mw-page-title-main">Multidrug and toxin extrusion protein 1</span> Protein-coding gene in the species Homo sapiens

Multidrug and toxin extrusion protein 1 (MATE1), also known as solute carrier family 47 member 1, is a protein that in humans is encoded by the SLC47A1 gene. SLC47A1 belongs to the MATE family of transporters that are found in bacteria, archaea and eukaryotes.

<span class="mw-page-title-main">Cationic amino acid transporter 3</span> Protein-coding gene in humans

Cationic amino acid transporter 3 is a protein that in humans is encoded by the SLC7A3 gene.

<span class="mw-page-title-main">Solute carrier organic anion transporter family member 4A1</span> Protein-coding gene in the species Homo sapiens

Solute carrier organic anion transporter family member 4A1 is a protein that in humans is encoded by the SLCO4A1 gene.

<span class="mw-page-title-main">Vesicular glutamate transporter 1</span> Protein-coding gene in the species Homo sapiens

Vesicular glutamate transporter 1 (VGLUT1) is a protein that in humans is encoded by the SLC17A7 gene.

<span class="mw-page-title-main">Sodium-dependent phosphate transport protein 1</span> Protein-coding gene in the species Homo sapiens

Sodium-dependent phosphate transport protein 1 is a protein that in humans is encoded by the SLC17A1 gene.

<span class="mw-page-title-main">SLC22A7</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 22 member 7 is a protein that in humans is encoded by the gene SLC22A7.

<span class="mw-page-title-main">SLC22A9</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 22 member 9 is a protein that in humans is encoded by the SLC22A9 gene.

<span class="mw-page-title-main">Sodium-dependent phosphate transport protein 2C</span> Protein-coding gene in the species Homo sapiens

Sodium-dependent phosphate transport protein 2C is a protein that in humans is encoded by the SLC34A3 gene.

<span class="mw-page-title-main">Solute carrier organic anion transporter family member 2A1</span> Protein-coding gene in the species Homo sapiens

Solute carrier organic anion transporter family member 2A1, also known as the prostaglandin transporter (PGT), is a protein that in humans is encoded by the SLCO2A1 gene.

<span class="mw-page-title-main">SLC22A13</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 22 member 13 is a protein that in humans is encoded by the SLC22A13 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000197208 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020334 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 Gründemann, Dirk; Hartmann, Lea; Flögel, Svenja (May 2022). "The ergothioneine transporter (ETT): substrates and locations, an inventory". FEBS Letters. 596 (10): 1252–1269. doi:10.1002/1873-3468.14269. PMID   34958679. S2CID   245535600.
  6. "Entrez Gene: SLC22A4 solute carrier family 22 (ergothioneine transporter), member 4".
  7. Gründemann D, Harlfinger S, Golz S, Geerts A, Lazar A, Berkels R, Jung N, Rubbert A, Schömig E (Apr 2005). "Discovery of the ergothioneine transporter". Proceedings of the National Academy of Sciences of the United States of America. 102 (14): 5256–61. Bibcode:2005PNAS..102.5256G. doi: 10.1073/pnas.0408624102 . PMC   555966 . PMID   15795384.
  8. Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (Nov 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney International. 64 (5): 1733–45. doi: 10.1046/j.1523-1755.2003.00266.x . PMID   14531806.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.