SLC27A6

SLC27A6
Identifiers
Aliases	SLC27A6 , ACSVL2, FACVL2, FATP6, VLCS-H1, solute carrier family 27 member 6
External IDs	OMIM: 604196; MGI: 3036230; HomoloGene: 38385; GeneCards: SLC27A6; OMA:SLC27A6 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q23.3 Start 128,538,013 bp [1] End 129,033,642 bp [1]
Gene location (Mouse) Chr. Chromosome 18 (mouse) [2] Band 18|18 D3 Start 58,689,329 bp [2] End 58,745,845 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte right uterine tube apex of heart left ventricle right ventricle myocardium testicle right adrenal cortex hair follicle right auricle Top expressed in blastocyst spermatocyte lower respiratory tract lung lip hair placenta ovary zone of skin testicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function long-chain fatty acid-CoA ligase activity nucleotide binding very long-chain fatty acid-CoA ligase activity catalytic activity ligase activity fatty acid transmembrane transporter activity long-chain fatty acid transporter activity Cellular component integral component of membrane plasma membrane sarcolemma membrane Biological process metabolism very long-chain fatty acid metabolic process lipid transport fatty acid transport fatty acid metabolic process lipid metabolism long-chain fatty acid transport long-chain fatty acid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 28965 225579 Ensembl ENSG00000113396 ENSMUSG00000024600 UniProt Q9Y2P4 E9Q9W4 RefSeq (mRNA) NM_001017372 NM_014031 NM_001317984 NM_001081072 RefSeq (protein) NP_001017372 NP_001304913 NP_054750 NP_001074541 Location (UCSC) Chr 5: 128.54 – 129.03 Mb Chr 18: 58.69 – 58.75 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Long-chain fatty acid transport protein 6 is a protein that in humans is encoded by the SLC27A6 gene. ^{[5] [6] [7]}

This gene encodes a member of the fatty acid transport protein family (FATP). FATPs are involved in the uptake of long-chain fatty acids and have unique expression patterns. Alternatively spliced transcript variants encoding the same protein have been found for this gene. ^[7]

See also

• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000113396 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024600 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gimeno RE, Ortegon AM, Patel S, Punreddy S, Ge P, Sun Y, Lodish HF, Stahl A (Apr 2003). "Characterization of a heart-specific fatty acid transport protein". J Biol Chem. 278 (18): 16039–44. doi: 10.1074/jbc.M211412200 . PMID   12556534.
6. Steinberg SJ, Wang SJ, McGuinness MC, Watkins PA (Oct 1999). "Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein". Mol Genet Metab. 68 (1): 32–42. doi: 10.1006/mgme.1999.2883 . PMID   10479480.
7. "Entrez Gene: SLC27A6 solute carrier family 27 (fatty acid transporter), member 6".

Further reading

• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070. S2CID   8235923.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Steinberg SJ, Mihalik SJ, Kim DG, et al. (2000). "The human liver-specific homolog of very long-chain acyl-CoA synthetase is cholate:CoA ligase". J. Biol. Chem. 275 (21): 15605–8. doi: 10.1074/jbc.C000015200 . PMID   10749848.
• Watkins PA, Pevsner J, Steinberg SJ (2000). "Human very long-chain acyl-CoA synthetase and two human homologs: initial characterization and relationship to fatty acid transport protein". Prostaglandins Leukot. Essent. Fatty Acids. 60 (5–6): 323–8. doi: 10.1016/S0952-3278(99)80007-6 . PMID   10471116.
• Hirsch D, Stahl A, Lodish HF (1998). "A family of fatty acid transporters conserved from mycobacterium to man". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8625–9. Bibcode:1998PNAS...95.8625H. doi: 10.1073/pnas.95.15.8625 . PMC   21126 . PMID   9671728.