SLC15A2

SLC15A2
Identifiers
Aliases	SLC15A2 , PEPT2, solute carrier family 15 member 2
External IDs	OMIM: 602339 MGI: 1890457 HomoloGene: 56912 GeneCards: SLC15A2
Gene location (Human)
Chr.	Chromosome 3 (human)
End	121,944,188 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	36,605,324 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; palpebral conjunctiva; ; corpus epididymis; ; parotid gland; ; seminal vesicula; ; trachea; ; urethra; ; entorhinal cortex; ; optic nerve; ; prostate;
	Top expressed in
	conjunctival fornix; ; olfactory epithelium; ; kidney; ; parotid gland; ; seminal vesicula; ; lacrimal gland; ; saccule; ; Paneth cell; ; trachea; ; substantia nigra;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	peptide:proton symporter activity ; protein binding ; symporter activity ; transporter activity ; transmembrane transporter activity ; oligopeptide transmembrane transporter activity ; dipeptide transmembrane transporter activity ; peptide transmembrane transporter activity ;
Cellular component	integral component of membrane ; plasma membrane ; integral component of plasma membrane ; extracellular exosome ; membrane ;
Biological process	protein transport ; peptide transport ; oligopeptide transport ; ion transport ; transmembrane transport ; transport ; dipeptide transmembrane transport ; oligopeptide transmembrane transport ; proton transmembrane transport ; xenobiotic detoxification by transmembrane export across the plasma membrane ;
	Sources:Amigo / QuickGO
Orthologs
	6565
	57738
	ENSG00000163406
	ENSMUSG00000022899
	Q16348
	Q9ES07
	NM_001145998 ; NM_021082
	NM_001145899 ; NM_021301
	NP_001139470 ; NP_066568
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Solute carrier family 15 (H+/peptide transporter), member 2, also known as SLC15A2, is a human gene.^[5]

Related Research Articles

Peptide transporter 1 also known as solute carrier family 15 member 1 (SLC15A1) is a protein that in humans is encoded by SLC15A1 gene. PepT 1 is a solute carrier for oligopeptides. It functions in renal oligopeptide reabsorption and in the intestines in a proton dependent way, hence acting like a cotransporter.

Sodium bicarbonate cotransporter 3 is a protein which in humans is encoded by the SLC4A7 gene.

Solute carrier family 22 member 2 is a protein that in humans is encoded by the SLC22A2 gene.

Solute carrier organic anion transporter family member 1B1 is a protein that in humans is encoded by the SLCO1B1 gene. Pharmacogenomic research indicates that genetic variations in this gene are associated with response to simvastatin. Clinical guidelines exist that can guide dosing of simvastatin based on SLCO1B1 gene variant using genotyping or whole exome sequencing.

Equilibrative nucleoside transporter 2 (ENT2) is a protein that in humans is encoded by the SLC29A2 gene.

Solute carrier family 22 member 3 (SLC22A3) also known as the organic cation transporter 3 (OCT3) or extraneuronal monoamine transporter (EMT) is a protein that in humans is encoded by the SLC22A3 gene.

Concentrative nucleoside transporter 2 (CNT2) is a protein that in humans is encoded by the SLC28A2 gene.

Solute carrier family 22 member 11 is a protein that in humans is encoded by the SLC22A11 gene.

Concentrative nucleoside transporter 1 (CNT1) is a protein that in humans is encoded by the SLC28A1 gene.

Neutral amino acid transporter A is a protein that in humans is encoded by the SLC1A4 gene.

Sodium-dependent phosphate transport protein 2B (NaPi2b) is a protein that in humans is encoded by the SLC34A2 gene.

Multidrug and toxin extrusion protein 1 (MATE1), also known as solute carrier family 47 member 1, is a protein that in humans is encoded by the SLC47A1 gene. SLC47A1 belongs to the MATE family of transporters that are found in bacteria, archaea and eukaryotes.

Solute carrier organic anion transporter family member 2B1 also known as organic anion-transporting polypeptide 2B1 (OATP2B1) is a protein that in humans is encoded by the gene SLCO2B1.

Sodium-coupled monocarboxylate transporter 1 is a protein that in humans is encoded by the SLC5A8 gene.

Sodium-dependent phosphate transport protein 1 is a protein that in humans is encoded by the SLC17A1 gene.

Solute carrier family 13 member 3 also called sodium-dependent dicarboxylate transporter (NaDC3) is a protein that in humans is encoded by the SLC13A3 gene.

Solute carrier family 13 member 2 is a protein that is encoded in humans by the SLC13A2 gene.

Solute carrier family 22 member 7 is a protein that in humans is encoded by the gene SLC22A7.

Solute carrier family 6, member 18 also known as SLC6A18 is a protein which in humans is encoded by the SLC6A18 gene.

The organic anion transporter 1 (OAT1) also known as solute carrier family 22 member 6 (SLC22A6) is a protein that in humans is encoded by the SLC22A6 gene. It is a member of the organic anion transporter (OAT) family of proteins. OAT1 is a transmembrane protein that is expressed in the brain, the placenta, the eyes, smooth muscles, and the basolateral membrane of proximal tubular cells of the kidneys. It plays a central role in renal organic anion transport. Along with OAT3, OAT1 mediates the uptake of a wide range of relatively small and hydrophilic organic anions from plasma into the cytoplasm of the proximal tubular cells of the kidneys. From there, these substrates are transported into the lumen of the nephrons of the kidneys for excretion. OAT1 homologs have been identified in rats, mice, rabbits, pigs, flounders, and nematodes.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000163406 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022899 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: SLC15A2 solute carrier family 15 (H+/peptide transporter), member 2".

Liu W, Liang R, Ramamoorthy S, et al. (1995). "Molecular cloning of PEPT 2, a new member of the H+/peptide cotransporter family, from human kidney". Biochim. Biophys. Acta. 1235 (2): 461–6. doi: 10.1016/0005-2736(95)80036-F . PMID 7756356.
Döring F, Martini C, Walter J, Daniel H (2002). "Importance of a small N-terminal region in mammalian peptide transporters for substrate affinity and function". J. Membr. Biol. 186 (2): 55–62. doi:10.1007/s00232-001-0135-9. PMID 11944083. S2CID 11211548.
Alcorn J, Lu X, Moscow JA, McNamara PJ (2002). "Transporter gene expression in lactating and nonlactating human mammary epithelial cells using real-time reverse transcription-polymerase chain reaction". J. Pharmacol. Exp. Ther. 303 (2): 487–96. doi:10.1124/jpet.102.038315. PMID 12388627. S2CID 16195525.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Groneberg DA (2003). "[Expression, localization and functional aspects of the peptide transporter PEPT2 in the normal respiratory tract and in cystic fibrosis]". Pneumologie (Stuttgart, Germany). 57 (2): 104–5. doi: 10.1055/s-2003-37158 . PMID 12579467.
Terada T, Irie M, Okuda M, Inui K (2004). "Genetic variant Arg57His in human H+/peptide cotransporter 2 causes a complete loss of transport function". Biochem. Biophys. Res. Commun. 316 (2): 416–20. doi:10.1016/j.bbrc.2004.02.063. PMID 15020234.
Pinsonneault J, Nielsen CU, Sadée W (2005). "Genetic variants of the human H+/dipeptide transporter PEPT2: analysis of haplotype functions". J. Pharmacol. Exp. Ther. 311 (3): 1088–96. doi:10.1124/jpet.104.073098. PMID 15282265. S2CID 12947228.
Bahadduri PM, D'Souza VM, Pinsonneault JK, et al. (2005). "Functional characterization of the peptide transporter PEPT2 in primary cultures of human upper airway epithelium". Am. J. Respir. Cell Mol. Biol. 32 (4): 319–25. doi:10.1165/rcmb.2004-0322OC. PMID 15626774.
Zhang EY, Emerick RM, Pak YA, et al. (2005). "Comparison of human and monkey peptide transporters: PEPT1 and PEPT2". Mol. Pharm. 1 (3): 201–10. doi:10.1021/mp0499712. PMID 15981923.
Noshiro R, Anzai N, Sakata T, et al. (2006). "The PDZ domain protein PDZK1 interacts with human peptide transporter PEPT2 and enhances its transport activity". Kidney Int. 70 (2): 275–82. doi: 10.1038/sj.ki.5001522 . PMID 16738539.
Søndergaard H, Bravo S, Nielsen CU, et al. (2008). "Cloning of the pig PEPT2 (pPEPT2) and characterization of the effects of epidermal growth factor (EGF) on pPEPT2-mediated peptide uptake in the renal porcine cell line LLC-PK1". Eur. J. Pharm. Sci. 33 (4): 332–42. doi: 10.1016/j.ejps.2008.01.001 . PMID 18295462.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000163406 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022899 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SLC15A2 solute carrier family 15 (H+/peptide transporter), member 2".

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SLC15A2

Contents

See also

Related Research Articles

References

Further reading