Monocarboxylate transporter 10

SLC16A10
Identifiers
Aliases	SLC16A10 , MCT10, PRO0813, TAT1, solute carrier family 16 member 10
External IDs	OMIM: 607550 MGI: 1919722 HomoloGene: 75089 GeneCards: SLC16A10
Gene location (Human)
Chr.	Chromosome 6 (human)
End	111,231,194 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	40,018,254 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; secondary oocyte; ; duodenum; ; vastus lateralis muscle; ; jejunal mucosa; ; vulva; ; body of pancreas; ; deltoid muscle; ; human penis; ; amniotic fluid;
	Top expressed in
	jejunum; ; secondary oocyte; ; islet of Langerhans; ; liver; ; blood; ; ileum; ; quadriceps femoris muscle; ; triceps brachii muscle; ; bone marrow; ; duodenum;
	More reference expression data
	n/a
Gene ontology
Molecular function	aromatic amino acid transmembrane transporter activity ; thyroid hormone transmembrane transporter activity ; amino acid transmembrane transporter activity ; monocarboxylic acid transmembrane transporter activity ;
Cellular component	plasma membrane ; basolateral plasma membrane ; integral component of plasma membrane ; membrane ; integral component of membrane ;
Biological process	thyroid hormone transport ; amino acid transport ; aromatic amino acid transport ; transmembrane transport ; amino acid transmembrane transport ; monocarboxylic acid transport ;
	Sources:Amigo / QuickGO
Orthologs
	117247
	72472
	ENSG00000112394
	ENSMUSG00000019838
	Q8TF71
	Q3U9N9
	NM_018593
	NM_001114332 ; NM_028247
	NP_061063
	NP_001107804 ; NP_082523
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 01, 2024

Monocarboxylate transporter 10 (MCT 10), also known as aromatic amino acid transporter 1 and T-type amino acid transporter 1 (TAT1) and solute carrier family 16 member 10 (SLC16A10), is a protein that in humans is encoded by the SLC16A10 gene.^[5]^[6]^[7] SLC16A10 is a member of the solute carrier family.

Function

SLC16A10 mediates Na⁺-independent transport of tryptophan, tyrosine, phenylalanine, and L-DOPA.^[7]

Related Research Articles

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CD98 is a glycoprotein that is a heterodimer composed of SLC3A2 and SLC7A5 that forms the large neutral amino acid transporter (LAT1). LAT1 is a heterodimeric membrane transport protein that preferentially transports branched-chain and aromatic amino acids. LAT is highly expressed in brain capillaries relative to other tissues.

Neutral and basic amino acid transport protein rBAT is a protein that in humans is encoded by the SLC3A1 gene.

Excitatory amino acid transporter 3 (EAAT3), is a protein that in humans is encoded by the SLC1A1 gene.

Solute carrier family 22 member 1 is a protein that in humans is encoded by the gene SLC22A1.

Solute carrier family 22 member 11 is a protein that in humans is encoded by the SLC22A11 gene.

Monocarboxylate transporter 5 is a protein that in humans is encoded by the SLC16A4 gene.

Solute carrier family 22, member 12, also known as SLC22A12 and URAT1, is a protein which in humans is encoded by the SLC22A12 gene.

Sodium/bile acid cotransporter also known as the Na⁺-taurocholate cotransporting polypeptide (NTCP) or liver bile acid transporter (LBAT) is a protein that in humans is encoded by the SLC10A1 (solute carrier family 10 member 1) gene.

Cationic amino acid transporter 3 is a protein that in humans is encoded by the SLC7A3 gene.

Monocarboxylate transporter 4 (MCT4) also known as solute carrier family 16 member 3 is a protein that in humans is encoded by the SLC16A3 gene.

Monocarboxylate transporter 1 is a ubiquitous protein that in humans is encoded by the SLC16A1 gene. It is a proton coupled monocarboxylate transporter.

Solute carrier family 22 member 9 is a protein that in humans is encoded by the SLC22A9 gene.

Large neutral amino acids transporter small subunit 3 is a protein that in humans is encoded by the SLC43A1 gene.

Sodium-dependent neutral amino acid transporter B(0)AT1 is a protein that in humans is encoded by the SLC6A19 gene.

Large neutral amino acids transporter small subunit 1, also known as 4F2 light chain, or CD98 light chain is a protein that in humans is encoded by the SLC7A5 gene.

Asc-type amino acid transporter 1 (Asc-1) is a protein that in humans is encoded by the SLC7A10 gene.

Monocarboxylate transporter 9 is a protein that in humans is encoded by the SLC16A9 gene.

Monocarboxylate transporter 2 (MCT2) also known as solute carrier family 16 member 7 (SLC16A7) is a protein that in humans is encoded by the SLC16A7 gene. MCT2 is a proton-coupled monocarboxylate transporter. It catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactic acid, branched-chain oxo acids derived from [[leucine, valine, and isoleucine, and the ketone bodies acetoacetate and beta-hydroxybutyrate. It also functions as high-affinity pyruvate transporter.

Monocarboxylate transporter 3 (MCT3) also known as solute carrier family 16 member 8 is a protein that in humans is encoded by the SLC16A8 gene. MCT is a proton-coupled monocarboxylate transporter. It catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. It also functions as high-affinity pyruvate transporter.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000112394 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019838 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: solute carrier family 16".
↑ Kim DK, Kanai Y, Chairoungdua A, Matsuo H, Cha SH, Endou H (May 2001). "Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters". J. Biol. Chem. 276 (20): 17221–8. doi: 10.1074/jbc.M009462200 . PMID 11278508.
1 2 Kim DK, Kanai Y, Matsuo H, Kim JY, Chairoungdua A, Kobayashi Y, Enomoto A, Cha SH, Goya T, Endou H (January 2002). "The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location". Genomics. 79 (1): 95–103. doi:10.1006/geno.2001.6678. PMID 11827462.

Toure A, Morin L, Pineau C, et al. (2001). "Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling". J. Biol. Chem. 276 (23): 20309–15. doi: 10.1074/jbc.M011740200 . PMID 11278976.
Friesema EC, Jansen J, Jachtenberg JW, et al. (2008). "Effective cellular uptake and efflux of thyroid hormone by human monocarboxylate transporter 10". Mol. Endocrinol. 22 (6): 1357–69. doi:10.1210/me.2007-0112. PMC 5419535 . PMID 18337592.
Loubière LS, Vasilopoulou E, Bulmer JN, et al. (2010). "Expression of thyroid hormone transporters in the human placenta and changes associated with intrauterine growth restriction" (PDF). Placenta. 31 (4): 295–304. doi:10.1016/j.placenta.2010.01.013. PMID 20167367. Archived from the original (PDF) on 2021-05-03. Retrieved 2019-08-16.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Bröer S (2008). "Amino acid transport across mammalian intestinal and renal epithelia". Physiol. Rev. 88 (1): 249–86. doi:10.1152/physrev.00018.2006. PMID 18195088. S2CID 1834804.
Park SY, Kim JK, Kim IJ, et al. (2005). "Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule". Arch. Pharm. Res. 28 (4): 421–32. doi:10.1007/BF02977671. PMID 15918515. S2CID 2139640.
Halestrap AP, Meredith D (2004). "The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond". Pflügers Arch. 447 (5): 619–28. doi:10.1007/s00424-003-1067-2. PMID 12739169. S2CID 15498611.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000112394 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019838 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: solute carrier family 16".

[pmid11278508-6] Kim DK, Kanai Y, Chairoungdua A, Matsuo H, Cha SH, Endou H (May 2001). "Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters". J. Biol. Chem. 276 (20): 17221–8. doi: 10.1074/jbc.M009462200 . PMID 11278508.

[pmid11827462-7] 1 2 Kim DK, Kanai Y, Matsuo H, Kim JY, Chairoungdua A, Kobayashi Y, Enomoto A, Cha SH, Goya T, Endou H (January 2002). "The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location". Genomics. 79 (1): 95–103. doi:10.1006/geno.2001.6678. PMID 11827462.

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Monocarboxylate transporter 10

Contents

Function

See also

Related Research Articles

References

Further reading