| SLC22A18 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | SLC22A18 , BWR1A, BWSCR1A, HET, IMPT1, ITM, ORCTL2, SLC22A1L, TSSC5, p45-BWR1A, solute carrier family 22 member 18 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 602631; MGI: 1336884; HomoloGene: 1918; GeneCards: SLC22A18; OMA:SLC22A18 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Solute carrier family 22 member 18 is a protein that in humans is encoded by the SLC22A18 gene. [5] [6] [7]
This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region as well as the transport of chloroquine- and quinidine-related compounds in the kidney. Two alternative transcripts encoding the same isoform have been described. [7]
b(0,+)-type amino acid transporter 1, also known as b(0,+)AT1, is a protein which in humans is encoded by the SLC7A9 gene.
Krueppel-like factor 6 is a protein that in humans is encoded by the KLF6 gene.
Peptide transporter 1 also known as solute carrier family 15 member 1 (SLC15A1) is a protein that in humans is encoded by SLC15A1 gene. PepT 1 is a solute carrier for oligopeptides. It functions in renal oligopeptide reabsorption and in the intestines in a proton dependent way, hence acting like a cotransporter.
Cyclin-dependent kinase inhibitor 1C , also known as CDKN1C, is a protein which in humans is encoded by the CDKN1C imprinted gene.
Solute carrier family 22 member 2 is a protein that in humans is encoded by the SLC22A2 gene.
Solute carrier family 22 member 1 is a protein that in humans is encoded by the gene SLC22A1.
Chloride anion exchanger, also known as down-regulated in adenoma, is a protein that in humans is encoded by the SLC26A3 gene.
Sialin, also known as H(+)/nitrate cotransporter and H(+)/sialic acid cotransporter, is a protein which in humans is encoded by the SLC17A5 gene.
Equilibrative nucleoside transporter 2 (ENT2) is a protein that in humans is encoded by the SLC29A2 gene.
Pleckstrin homology-like domain family A member 2 is a protein that in humans is encoded by the PHLDA2 gene.
Large tumor suppressor kinase 1 (LATS1) is an enzyme that in humans is encoded by the LATS1 gene.
KCNQ1 overlapping transcript 1, also known as KCNQ1OT1, is a long non-coding RNA gene found in the KCNQ1 locus. This locus consists of 8–10 protein-coding genes, specifically expressed from the maternal allele, and the paternally expressed non-coding RNA gene KCNQ1OT1. KCNQ1OT1 and KCNQ1 are imprinted genes and are part of an imprinting control region (ICR). Mitsuya identified that KCNQ1OT1 is an antisense transcript of KCNQ1. KCNQ1OT1 is a paternally expressed allele and KCNQ1 is a maternally expressed allele. KCNQ1OT1 is a nuclear, 91 kb transcript, found in close proximity to the nucleolus in certain cell types.
Solute carrier family 22 member 11 is a protein that in humans is encoded by the SLC22A11 gene.
Sodium-coupled neutral amino acid transporter 3 is a protein that in humans is encoded by the SLC38A3 gene.
Choline transporter-like protein 1 is a protein that in humans is encoded by the SLC44A1 gene.
Choline transporter-like protein 4 is a protein that in humans is encoded by the SLC44A4 gene.
Nucleosome assembly protein 1-like 4 is a protein that in humans is encoded by the NAP1L4 gene.
Tetraspanin-32 is a protein that in humans is encoded by the TSPAN32 gene.
Sodium-dependent phosphate transport protein 1 is a protein that in humans is encoded by the SLC17A1 gene.
Solute carrier family 25 member 22 is a protein that in humans is encoded by the SLC25A22 gene. This gene encodes a mitochondrial glutamate carrier. Mutations in this gene are associated with early infantile epileptic encephalopathy. Expression of this gene is increased in colorectal tumor cells.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
