RHCG

Last updated

RHCG
Rhcg 3hd6.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases RHCG , C15orf6, PDRC2, RHGK, SLC42A3, Rh family C glycoprotein
External IDs OMIM: 605381; MGI: 1888517; HomoloGene: 32310; GeneCards: RHCG; OMA:RHCG - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016321
NM_001321041

NM_019799

RefSeq (protein)

NP_001307970
NP_057405

NP_062773

Location (UCSC) Chr 15: 89.47 – 89.5 Mb Chr 7: 79.24 – 79.27 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Rh family, C glycoprotein, also known as RHCG, is a protein that in humans is encoded by the RHCG gene. [5] [6]

Contents

Function

RHCG plays a critical role in ammonium handling and pH homeostasis in the kidney. [7] The structure of the RHCG protein [8] indicates that it has a hydrophobic ammonia-conducting channel and shows that it shares a common fold with the ammonia transporters, thus making it an ammonia transporter.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000140519 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030549 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: RHCG Rh family, C glycoprotein".
  6. Liu Z, Chen Y, Mo R, Hui C, Cheng JF, Mohandas N, Huang CH (August 2000). "Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis". J. Biol. Chem. 275 (33): 25641–51. doi: 10.1074/jbc.M003353200 . PMID   10852913.
  7. Biver S, Belge H, Bourgeois S, Van Vooren P, Nowik M, Scohy S, Houillier P, Szpirer J, Szpirer C, Wagner CA, Devuyst O, Marini AM (November 2008). "A role for Rhesus factor Rhcg in renal ammonium excretion and male fertility". Nature. 456 (7220): 339–43. Bibcode:2008Natur.456..339B. doi:10.1038/nature07518. PMID   19020613. S2CID   205215412.
  8. PDB: 3hd6 ; Gruswitz F, Chaudhary S, Ho JD, Schlessinger A, Pezeshki B, Ho CM, Sali A, Westhoff CM, Stroud RM (May 2010). "Function of human Rh based on structure of RhCG at 2.1 A". Proc. Natl. Acad. Sci. U.S.A. 107 (21): 9638–43. Bibcode:2010PNAS..107.9638G. doi: 10.1073/pnas.1003587107 . PMC   2906887 . PMID   20457942.

Further reading