SLC2A9

Last updated
SLC2A9
Identifiers
Aliases SLC2A9 , solute carrier family 2 (facilitated glucose transporter), member 9, GLUT9, GLUTX, UAQTL2, URATv1, solute carrier family 2 member 9
External IDs OMIM: 606142 MGI: 2152844 HomoloGene: 69290 GeneCards: SLC2A9
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001001290
NM_020041

NM_001012363
NM_001102414
NM_001102415
NM_145559

RefSeq (protein)

NP_001001290
NP_064425

NP_001012363
NP_001095884
NP_001095885
NP_663534

Location (UCSC) Chr 4: 9.77 – 10.05 Mb Chr 5: 38.51 – 38.66 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Solute carrier family 2, facilitated glucose transporter member 9 is a protein that in humans is encoded by the SLC2A9 gene. [5] [6] [7]

Contents

This gene encodes a member of the SLC2A facilitative glucose transporter family. Members of this family play a significant role in maintaining glucose homeostasis. The encoded protein may play a role in the development and survival of chondrocytes in cartilage matrices. Two transcript variants encoding distinct isoforms have been identified for this gene. [7]

SLC2A9 has also recently been found to transport uric acid, and genetic variants of the transporter have been linked to increased risk of development of both hyperuricemia, gout and Alzheimer's disease. [8] [9] [10]

See also

Related Research Articles

Glucose transporter 1, also known as solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), is a uniporter protein that in humans is encoded by the SLC2A1 gene. GLUT1 facilitates the transport of glucose across the plasma membranes of mammalian cells. This gene encodes a facilitative glucose transporter that is highly expressed in erythrocytes and endothelial cells, including cells of the blood–brain barrier. The encoded protein is found primarily in the cell membrane and on the cell surface, where it can also function as a receptor for human T-cell leukemia virus (HTLV) I and II. GLUT1 accounts for 2 percent of the protein in the plasma membrane of erythrocytes. Mutations in this gene can cause GLUT1 deficiency syndrome 1, GLUT1 deficiency syndrome 2, idiopathic generalized epilepsy 12, dystonia 9, and stomatin-deficient cryohydrocytosis.

<span class="mw-page-title-main">Zinc transporter 8</span> Protein-coding gene in the species Homo sapiens

Zinc transporter 8 (ZNT8) is a protein that in humans is encoded by the SLC30A8 gene. ZNT8 is a zinc transporter related to insulin secretion in humans. Certain alleles of the SLC30A8 gene may increase the risk for developing type 2 diabetes, but a loss-of-function mutation appears to greatly reduce the risk of diabetes.

Glucose transporter 3, also known as solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3) is a protein that in humans is encoded by the SLC2A3 gene. GLUT3 facilitates the transport of glucose across the plasma membranes of mammalian cells. GLUT3 is most known for its specific expression in neurons and has originally been designated as the neuronal GLUT. GLUT3 has been studied in other cell types with specific glucose requirements, including sperm, preimplantation embryos, circulating white blood cells and carcinoma cell lines.

<span class="mw-page-title-main">SLC22A2</span> Protein-coding gene

Solute carrier family 22 member 2 is a protein that in humans is encoded by the SLC22A2 gene.

<span class="mw-page-title-main">SLC23A2</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 23 member 2 is a protein that in humans is encoded by the SLC23A2 gene.

<span class="mw-page-title-main">SLC22A11</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 22 member 11 is a protein that in humans is encoded by the SLC22A11 gene.

<span class="mw-page-title-main">Sodium bicarbonate transporter-like protein 11</span> Protein-coding gene in the species Homo sapiens

Sodium bicarbonate transporter-like protein 11 is a protein that in humans is encoded by the SLC4A11 gene.

<span class="mw-page-title-main">SLC2A10</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 2, facilitated glucose transporter member 10 is a protein that in humans is encoded by the SLC2A10 gene.

<span class="mw-page-title-main">SLC22A12</span> Mammalian protein found in Homo sapiens

Solute carrier family 22, member 12, also known as SLC22A12 and URAT1, is a protein which in humans is encoded by the SLC22A12 gene.

<span class="mw-page-title-main">SLC2A12</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 2, facilitated glucose transporter member 12 is a protein that in humans is encoded by the SLC2A12 gene.

<span class="mw-page-title-main">SLC2A6</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 2, facilitated glucose transporter member 6 is a protein that in humans is encoded by the SLC2A6 gene.

<span class="mw-page-title-main">Vesicular inhibitory amino acid transporter</span> Protein-coding gene in the species Homo sapiens

Vesicular inhibitory amino acid transporter is a protein that in humans is encoded by the SLC32A1 gene.

<span class="mw-page-title-main">Sodium-dependent phosphate transport protein 1</span> Protein-coding gene in the species Homo sapiens

Sodium-dependent phosphate transport protein 1 is a protein that in humans is encoded by the SLC17A1 gene.

<span class="mw-page-title-main">SLC22A9</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 22 member 9 is a protein that in humans is encoded by the SLC22A9 gene.

<span class="mw-page-title-main">SLC6A18</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 6, member 18 also known as SLC6A18 is a protein which in humans is encoded by the SLC6A18 gene.

<span class="mw-page-title-main">SLC2A7</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 2, facilitated glucose transporter member 7 also known as glucose transporter 7 (GLUT7) is a protein that in humans is encoded by the SLC2A7 gene.

<span class="mw-page-title-main">SLC17A3</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 17, member 3 is a protein that in humans is encoded by the SLC17A3 gene.

<span class="mw-page-title-main">SLC2A11</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 2, facilitated glucose transporter member 11 (SLC2A11) also known as glucose transporter type 10/11 (GLUT-10/11) is a protein that in humans is encoded by the SLC2A11 gene.

<span class="mw-page-title-main">SLC2A14</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 2, member 14 is a protein that in humans is encoded by the SLC2A14 gene.

<span class="mw-page-title-main">SLC22A13</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 22 member 13 is a protein that in humans is encoded by the SLC22A13 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000109667 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005107 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Phay JE, Hussain HB, Moley JF (Aug 2000). "Cloning and expression analysis of a novel member of the facilitative glucose transporter family, SLC2A9 (GLUT9)". Genomics. 66 (2): 217–20. doi:10.1006/geno.2000.6195. PMID   10860667.
  6. Manolescu AR, Augustin R, Moley K, Cheeseman C (Aug 2007). "A highly conserved hydrophobic motif in the exofacial vestibule of fructose transporting SLC2A proteins acts as a critical determinant of their substrate selectivity". Mol Membr Biol. 24 (5–6): 455–63. doi:10.1080/09687680701298143. PMID   17710649. S2CID   35331716.
  7. 1 2 "SLC2A9 solute carrier family 2 member 9 [ Homo sapiens (human) ]".
  8. Vitart V, Rudan I, Hayward C, et al. (2008). "SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout". Nature Genetics. 40 (4): 437–42. doi:10.1038/ng.106. PMID   18327257. S2CID   6720464.
  9. Döring A, Gieger C, Mehta D, et al. (2008). "SLC2A9 influences uric acid concentrations with pronounced sex-specific effects". Nature Genetics. 40 (4): 430–6. doi:10.1038/ng.107. PMID   18327256. S2CID   29751482.
  10. Hollingworth P, Sweet R, Sims R, et al. (2012). "Genome-wide association study of Alzheimer's disease with psychotic symptoms". Molecular Psychiatry. 17 (12): 1316–1327. doi:10.1038/mp.2011.125. PMC   3272435 . PMID   22005930.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.